دورية أكاديمية
Evaluation of the stage classification of anal cancer by the TNM 8th version versus the TNM 7th version.
| العنوان: | Evaluation of the stage classification of anal cancer by the TNM 8th version versus the TNM 7th version. |
|---|---|
| المؤلفون: | Dahl O; Department of Oncology, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Science, Medical Faculty, University of Bergen, Bergen, Norway., Myklebust MP; Department of Oncology, Haukeland University Hospital, Bergen, Norway., Dale JE; Department of Oncology, Haukeland University Hospital, Bergen, Norway., Leon O; Department of Oncology, Skåne University Hospital, Lund, Sweden., Serup-Hansen E; Department of Oncology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark., Jakobsen A; Department of Oncology, Vejle Hospital, University of Southern Denmark, Vejle, Denmark., Pfeiffer P; Department of Oncology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Odense C, Denmark., Løes IM; Department of Oncology, Haukeland University Hospital, Bergen, Norway., Pfeffer F; Department of Gastroenterological Surgery, Haukeland University Hospital, Bergen, Norway.; Department of Clinical Medicine, University of Bergen, Bergen, Norway., Spindler KG; Department of Experimental Clinical Oncology, Aarhus University Hospital, Aarhus, Denmark.; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark., Guren MG; Department of Oncology and K.G. Jebsen Colorectal Cancer Research Centre, Oslo University Hospital, Oslo, Norway., Glimelius B; Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden., Johnsson A; Department of Oncology, Skåne University Hospital, Lund, Sweden. |
| المصدر: | Acta oncologica (Stockholm, Sweden) [Acta Oncol] 2020 Sep; Vol. 59 (9), pp. 1016-1023. Date of Electronic Publication: 2020 Jun 23. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Medical Journals Sweden AB Country of Publication: England NLM ID: 8709065 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1651-226X (Electronic) Linking ISSN: 0284186X NLM ISO Abbreviation: Acta Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : [Uppsala, Sweden] : Medical Journals Sweden AB Original Publication: Stockholm, Sweden : Acta Oncologica, [1987- |
| مواضيع طبية MeSH: | Anal Canal/*pathology , Anus Neoplasms/*diagnosis, Adult ; Aged ; Aged, 80 and over ; Anus Neoplasms/mortality ; Anus Neoplasms/pathology ; Denmark ; Female ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Norway ; Prognosis ; Retrospective Studies ; Survival Analysis ; Sweden |
| مستخلص: | Background : The UICC TNM 7th edition introduced stage groups for anal cancer which in 2019 has not yet come into general use. The new TNM 8th edition from 2016 defines 7 sub-stages. Background data for these changes are lacking. We aimed to investigate whether the new classification for anal cancer reliably predict the prognosis in the different stages. Patients and methods : The Nordic Anal Cancer Group (NOAC) conducted a large retrospective study of all anal cancers in Norway, Sweden and most of Denmark in 2000-2007. From the Nordic cohort 1151 anal cancer patients with follow-up data were classified by the TNM 4th edition which has identical T, N and M definitions as the TNM 7th edition, and therefore also can be classified by the TNM 7th stage groups. We used the Nordic cohort to translate the T, N and M stages into the TNM 8th stages and sub-stages. Overall survival for each stage was assessed. Results : Although the summary stage groups for TNM 8th edition discriminates patients with different prognosis reasonably well, the analyses of the seven sub-stages show overlapping overall survival: HR for stage IIA 1.30 (95%CI 0.80-2.12) is not significantly different from stage I ( p = .30) and HR for stage IIB 2.35 (95%CI 1.40-3.95) and IIIA 2.48 (95%CI 1.43-4.31) are also similar as were HRs for stage IIIB 3.41 (95%CI 1.99-5.85) and IIIC 3.22 (95%CI 1.99-5.20). Similar overlapping was shown for local recurrence and distant spread. Conclusion : The results for the sub-stages calls for a revision of the staging system. We propose a modification of the TNM 8th edition for staging of anal cancer into four stages based on the T, N and M definitions of the TNM 8th classification. |
| تواريخ الأحداث: | Date Created: 20200624 Date Completed: 20210617 Latest Revision: 20210617 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1080/0284186X.2020.1778180 |
| PMID: | 32574087 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1651-226X |
|---|---|
| DOI: | 10.1080/0284186X.2020.1778180 |