Editorial & Opinion
Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts.
| العنوان: | Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts. |
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| المؤلفون: | Perner F; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Gadrey JY; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Xiong Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Hatton C; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Eschle BK; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Weiss A; Novartis Institutes for Biomedical Research, Basel, Switzerland., Stauffer F; Novartis Institutes for Biomedical Research, Basel, Switzerland., Gaul C; Novartis Institutes for Biomedical Research, Basel, Switzerland., Tiedt R; Novartis Institutes for Biomedical Research, Basel, Switzerland., Perry JA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and., Krivtsov AV; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, MA; and. |
| المصدر: | Blood [Blood] 2020 Oct 22; Vol. 136 (17), pp. 1983-1988. |
| نوع المنشور: | Letter |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2021- : [New York] : Elsevier Original Publication: New York, Grune & Stratton [etc.] |
| مواضيع طبية MeSH: | Benzimidazoles/*therapeutic use , Enzyme Inhibitors/*therapeutic use , Histone-Lysine N-Methyltransferase/*antagonists & inhibitors , Leukemia/*drug therapy, Animals ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Benzimidazoles/pharmacokinetics ; Drugs, Investigational/pharmacokinetics ; Drugs, Investigational/therapeutic use ; Enzyme Inhibitors/pharmacokinetics ; Humans ; Jurkat Cells ; K562 Cells ; Leukemia/pathology ; Mice ; Treatment Outcome ; Tumor Cells, Cultured ; Xenograft Model Antitumor Assays |
| References: | Blood. 2013 Mar 28;121(13):2533-41. (PMID: 23361907) Nat Rev Cancer. 2007 Nov;7(11):823-33. (PMID: 17957188) Arch Pathol Lab Med. 2017 Nov;141(11):1462-1468. (PMID: 29072953) Blood. 2013 Aug 8;122(6):1017-25. (PMID: 23801631) Cancer Discov. 2016 Oct;6(10):1166-1181. (PMID: 27535106) Cancer Cell. 2019 Dec 9;36(6):660-673.e11. (PMID: 31821784) Leukemia. 2018 Feb;32(2):273-284. (PMID: 28701730) Blood. 2017 Jan 26;129(4):424-447. (PMID: 27895058) Leukemia. 2017 Jan;31(1):151-158. (PMID: 27363283) ACS Med Chem Lett. 2019 Dec 04;10(12):1655-1660. (PMID: 31857842) Cancer Cell. 2011 Jul 12;20(1):66-78. (PMID: 21741597) Blood. 2018 Jun 14;131(24):2661-2669. (PMID: 29724899) Science. 2020 Jan 31;367(6477):586-590. (PMID: 32001657) Epigenomics. 2011 Dec;3(6):667-70. (PMID: 22126283) Nat Med. 2015 Apr;21(4):335-43. (PMID: 25822366) Exp Hematol. 2015 Aug;43(8):673-84. (PMID: 26118503) |
| معلومات مُعتمدة: | R01 CA176745 United States CA NCI NIH HHS |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Benzimidazoles) 0 (Drugs, Investigational) 0 (EPZ-5676) 0 (Enzyme Inhibitors) EC 2.1.1.- (DOT1L protein, human) EC 2.1.1.43 (Histone-Lysine N-Methyltransferase) |
| تواريخ الأحداث: | Date Created: 20200624 Date Completed: 20210324 Latest Revision: 20211023 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8209563 |
| DOI: | 10.1182/blood.2020006113 |
| PMID: | 32575123 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1528-0020 |
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| DOI: | 10.1182/blood.2020006113 |