دورية أكاديمية
أعرض في EDS

Alpha-terpineol complexed with beta-cyclodextrin reduces damages caused by periodontitis in rats.

التفاصيل البيبلوغرافية
العنوان: Alpha-terpineol complexed with beta-cyclodextrin reduces damages caused by periodontitis in rats.
المؤلفون: Vasconcelos ACCG; Medicinal Plants Research Center (NPPM), Federal University of hPiaui, Teresina, Brazil.; Medicine School, Education Institute of Parnaiba Valley (IESVAP-Afya), Parnaiba, Brazil., Vasconcelos DFP; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., da Silva FRP; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., França LFC; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Alves EHP; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Di Lenardo D; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Pessoa LDS; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Nascimento HMS; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Carvalho ADS; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Sousa FBM; Laboratory of Experimental Psychopharmacology (LAFFEX), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Barbosa ALDR; Laboratory of Experimental Psychopharmacology (LAFFEX), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Medeiros JR; Laboratory of Experimental Psychopharmacology (LAFFEX), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Novaes PD; Department of Morphology, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, Brazil., Mariano FS; Department of Morphology, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, Brazil., Lima BDS; Department of Pharmacy, Federal University of Sergipe, Aracaju, Brazil., Araujo AAS; Department of Pharmacy, Federal University of Sergipe, Aracaju, Brazil., Júnior LJQ; Department of Pharmacy, Federal University of Sergipe, Aracaju, Brazil., de Oliveira AP; Medicinal Plants Research Center (NPPM), Federal University of hPiaui, Teresina, Brazil.
المصدر: Journal of periodontal research [J Periodontal Res] 2020 Dec; Vol. 55 (6), pp. 877-886. Date of Electronic Publication: 2020 Jun 25.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0055107 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0765 (Electronic) Linking ISSN: 00223484 NLM ISO Abbreviation: J Periodontal Res Subsets: MEDLINE
أسماء مطبوعة: Publication: Malden, MA : Wiley-Blackwell
Original Publication: Copenhagen : Munksgaard International Publishers
مواضيع طبية MeSH: Alveolar Bone Loss*/drug therapy , Alveolar Bone Loss*/prevention & control , Cyclohexane Monoterpenes*/pharmacology , Periodontitis*/drug therapy , beta-Cyclodextrins*, Animals ; Female ; Ligation ; Rats
مستخلص: Background and Objective: This study aimed to assess the effectiveness of the treatment with alpha-terpineol (αTPN) complexed with beta-cyclodextrin (βCD) on oral, blood, and hepatic parameters in ligature-induced periodontitis.
Material and Methods: Forty female rats were distributed among the following groups: control (vehicle solution), periodontitis (ligature + vehicle solution), 5 mg/kg of αTPN-βCD (ligature), and 25 mg/kg of αTPN-βCD (ligature). Compounds were administered daily via intraperitoneal injection over a 20-day period. Periodontitis was induced with the bilateral insertion of ligatures around the first lower molars of each rat. Oral parameters, as well as blood biomarkers, were measured: histopathological assessment of the hepatic tissue was carried out using light and transmission electron microscopy.
Results: The treatment with αTPN-βCD significantly improved several oral parameters and blood biomarkers in comparison with rats with periodontitis. In addition, the treatment with αTPN-βCD significantly ameliorated the steatosis score and reduced the number of lipid droplets and the amount of foamy cytoplasm in the hepatocytes of rats with periodontitis.
Conclusion: The results obtained suggest that the treatment with αTPN-βCD improves several oral and blood parameters in rats with experimental periodontitis. In addition, hepatic alterations caused by periodontitis were ameliorated in the rats treated with αTPN-βCD.
(© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
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معلومات مُعتمدة: PIBIC 2016/2017 Federal University; PIBIC 2017/2018 Federal University; PIBITI 2017/2018 Federal University; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 455104/2014-0 CNPq
فهرسة مساهمة: Keywords: alveolar bone loss; hepatocyte; liver; oral medicine; periodontal disease
المشرفين على المادة: 0 (Cyclohexane Monoterpenes)
0 (beta-Cyclodextrins)
21334LVV8W (alpha-terpineol)
تواريخ الأحداث: Date Created: 20200626 Date Completed: 20210118 Latest Revision: 20210118
رمز التحديث: 20240628
DOI: 10.1111/jre.12780
PMID: 32583890
قاعدة البيانات: MEDLINE
الوصف
تدمد:1600-0765
DOI:10.1111/jre.12780