دورية أكاديمية
Alpha-terpineol complexed with beta-cyclodextrin reduces damages caused by periodontitis in rats.
العنوان: | Alpha-terpineol complexed with beta-cyclodextrin reduces damages caused by periodontitis in rats. |
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المؤلفون: | Vasconcelos ACCG; Medicinal Plants Research Center (NPPM), Federal University of hPiaui, Teresina, Brazil.; Medicine School, Education Institute of Parnaiba Valley (IESVAP-Afya), Parnaiba, Brazil., Vasconcelos DFP; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., da Silva FRP; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., França LFC; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Alves EHP; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Di Lenardo D; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Pessoa LDS; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Nascimento HMS; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Carvalho ADS; Laboratory of Histological Analysis and Preparation (LAPHis), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Sousa FBM; Laboratory of Experimental Psychopharmacology (LAFFEX), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Barbosa ALDR; Laboratory of Experimental Psychopharmacology (LAFFEX), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Medeiros JR; Laboratory of Experimental Psychopharmacology (LAFFEX), Federal University of Parnaiba Delta (UFDPar), Parnaiba, Brazil., Novaes PD; Department of Morphology, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, Brazil., Mariano FS; Department of Morphology, Piracicaba Dental School, State University of Campinas - UNICAMP, Piracicaba, Brazil., Lima BDS; Department of Pharmacy, Federal University of Sergipe, Aracaju, Brazil., Araujo AAS; Department of Pharmacy, Federal University of Sergipe, Aracaju, Brazil., Júnior LJQ; Department of Pharmacy, Federal University of Sergipe, Aracaju, Brazil., de Oliveira AP; Medicinal Plants Research Center (NPPM), Federal University of hPiaui, Teresina, Brazil. |
المصدر: | Journal of periodontal research [J Periodontal Res] 2020 Dec; Vol. 55 (6), pp. 877-886. Date of Electronic Publication: 2020 Jun 25. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Wiley-Blackwell Country of Publication: United States NLM ID: 0055107 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0765 (Electronic) Linking ISSN: 00223484 NLM ISO Abbreviation: J Periodontal Res Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Malden, MA : Wiley-Blackwell Original Publication: Copenhagen : Munksgaard International Publishers |
مواضيع طبية MeSH: | Alveolar Bone Loss*/drug therapy , Alveolar Bone Loss*/prevention & control , Cyclohexane Monoterpenes*/pharmacology , Periodontitis*/drug therapy , beta-Cyclodextrins*, Animals ; Female ; Ligation ; Rats |
مستخلص: | Background and Objective: This study aimed to assess the effectiveness of the treatment with alpha-terpineol (αTPN) complexed with beta-cyclodextrin (βCD) on oral, blood, and hepatic parameters in ligature-induced periodontitis. Material and Methods: Forty female rats were distributed among the following groups: control (vehicle solution), periodontitis (ligature + vehicle solution), 5 mg/kg of αTPN-βCD (ligature), and 25 mg/kg of αTPN-βCD (ligature). Compounds were administered daily via intraperitoneal injection over a 20-day period. Periodontitis was induced with the bilateral insertion of ligatures around the first lower molars of each rat. Oral parameters, as well as blood biomarkers, were measured: histopathological assessment of the hepatic tissue was carried out using light and transmission electron microscopy. Results: The treatment with αTPN-βCD significantly improved several oral parameters and blood biomarkers in comparison with rats with periodontitis. In addition, the treatment with αTPN-βCD significantly ameliorated the steatosis score and reduced the number of lipid droplets and the amount of foamy cytoplasm in the hepatocytes of rats with periodontitis. Conclusion: The results obtained suggest that the treatment with αTPN-βCD improves several oral and blood parameters in rats with experimental periodontitis. In addition, hepatic alterations caused by periodontitis were ameliorated in the rats treated with αTPN-βCD. (© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.) |
References: | Kinane DF, Preshaw PM, Loos BG. Working Group 2 of Seventh European Workshop on Periodontology. Host-response: understanding the cellular and molecular mechanisms of host-microbial interactions-consensus of the Seventh European Workshop on Periodontology. J Clin Periodontol. 2011;38:44-48. White P, Sakellari D, Roberts H, et al. Peripheral blood neutrophil extracellular trap production and degradation in chronic periodontitis. J Clin Periodontol. 2016;12:1041-1049. Oliveira RR, Fermiano D, Feres M, et al. Levels of candidate periodontal pathogens in subgingival biofilm. J Dental Res. 2016;6:711-718. Tomofuji T, Ekuni D, Irie K, et al. Relationships between periodontal inflammation, lipid peroxide and oxidative damage of multiple organs in rats. Biomed Res. 2011;32:343-349. França LFC, Vasconcelos ACCG, da Silva FRP, et al. Periodontitis changes renal structures by oxidative stress and lipid peroxidation. J Clin Periodontol. 2017;44:568-576. Pessoa LS, Pereira-da Silva F, Alves E, et al. One or two ligatures inducing periodontitis are sufficient to cause fatty liver. Med Oral Patol Oral Cir Buccal. 2018;23:e269. dos Santos Carvalho J, Cardoso Guimarães Vasconcelos AC, Herlany Pereira Alves E, et al. Steatosis caused by experimental periodontitis is reversible after removal of ligature in rats. J Periodontal Res. 2017;52:883-892. Vasconcelos DFP, Pereira da Silva FR, Pinto MeSC, et al. Decrease of pericytes is associated with liver disease caused by ligature induced periodontitis in rats. J Periodontol. 2017;88:e49-e57. Vasconcelos ACCG, Vasconcelos DFP, Silva FRP, et al. Periodontitis causes abnormalities in the liver of rats. J Periodontol. 2018;90:295-305. Vasconcelos DFP, Marques MR, Benatti BB, Barros SP, Nociti Júnior FH, Novaes PD. Intermittent parathyroid hormone administration improves periodontal healing in rats. J Periodontol. 2014;85:721-728. Cortellini P, Buti J, Pini Prato G, Tonetti MS. Periodontal regeneration compared with access flap surgery in human intra-bony defects 20-year follow-up of a randomized clinical trial: tooth retention, periodontitis recurrence and costs. J Clin Periodontol. 2017;44:58-66. Oliveira MG, Marques RB, Santana MF, et al. a-Terpineol reduces mechanical hypernociception and inflammatory response. Basic Clin Pharmacol Toxicol. 2012;111:120-125. Gouveia DN, Costa JS, Oliveira MA, et al. α-Terpineol reduces cancer pain via modulation of oxidative stress and inhibition of iNOS. Biomed Pharmacother. 2018;105:652-661. Park SN, Lim YK, Freire MO, Cho E, Jin D, Kook JK. Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria. Anaerobe. 2012;18:369-372. Loftsson T, Jarho P, Másson M, Järvinen T. Cyclodextrins in drug delivery. Expert Opin Drug Deliv. 2005;2:335-351. Pinho E, Grootveld M, Soares G, Henriques M. Cyclodextrins as encapsulation agents for plant bioactive compounds. Carbohydr Polym. 2014;30:121-135. Zhang J, Ma PX. Cyclodextrin-based supramolecular systems for drug delivery: recent progress and future perspective. Adv Drug Deliv. 2013;65:1215-1233. De Oliveira MG, Guimarães AG, Araújo AA, Quintans JS, Santos MR, Quintans-Júnior LJ. Cyclodextrins: improving the therapeutic response of analgesic drugs: a patent review. Expert Opin Ther Pat. 2015;25:897-907. Liu R, Li N, Liu N, et al. Effects of systemic ornidazole, systemic and local compound ornidazole and pefloxacin mesylate on experimental periodontitis in rats. Med Sci Monit. 2012;18:BR95-102. Chaves LS, Nicolau LA, Silva RO, et al. Antiinflammatory and antinociceptive effects in mice of a sulfated polysaccharide fraction extracted from the marine red algae Gracilaria caudata. Immunopharmacol Immunotoxicol. 2013;35:93-100. Sedlak J, Lindsay RH. Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal Biochem. 1968;25:192-205. Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem. 1978;86:271-278. Watanabe E, Muenzer JT, Hawkins WG, et al. Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study. Lab Invest. 2009;89:549-561. Ghadially Bermudez FN. Ultrastructural Pathology of the Cell and Matrix, 3rd edn. Guildford, UK: Butterworth-Heinemann; 1988. Bermudez MA, Sendon-Lago J, Seoane S, et al. Anti-inflammatory effect of conditioned medium from human uterine cervical stem cells in uveitis. Exp Eye Res. 2006;149:84-92. Oliveira MG, Brito RG, Santos PL, et al. α-Terpineol, a monoterpene alcohol, complexed with β-cyclodextrin exerts antihyperalgesic effect in animal model for fibromyalgia aided with docking study. Chem Biol Interact. 2016;254:54-62. Kuo PJ, Hung TF, Lin CY, et al. Carvacrol ameliorates ligation-induced periodontitis in rats. J Periodontol. 2017;88:e120-e128. Yu M, Chen X, Lv C, et al. Curcumol suppresses RANKL-induced osteoclast formation by attenuating the JNK signaling pathway. Biochem Biophys Res Commun. 2014;447:364-370. Iqbal PS, Khan SN, Haris M, Narayanan M, Laju S, Kumar SS. Assessment of systemic inflammatory markers in patients with aggressive periodontitis. J Int Oral Health. 2015;7(2):48-51. França LFC, da Silva FRP, di Lenardo D, et al. Comparative analysis of blood parameters of the erythrocyte lineage between patients with chronic periodontitis and healthy patients: results obtained from a meta-analysis. Arch Oral Biol. 2019;97:144-149. Vallianou I, Peroulis N, Pantazis P, Hadzopoulou-Cladaras M. Camphene, a plant-derived monoterpene, reduces plasma cholesterol and triglycerides in hyperlipidemic rats independently of HMG-CoA reductase activity. PLoS One. 2011;6:e20516. Souza MDF, Medeiros JVR, Vasconcelos DFP, et al. Orabase formulation with cashew gum polysaccharide decreases inflammatory and bone loss hallmarks in experimental periodontitis. Int J Biol Macromol. 2018;107:1093-1101. Mikolasevic I, Milic S, Turk Wensveen T, et al. Nonalcoholic fatty liver disease - A multisystem disease? World J Gastroenterol. 2016;22:9488-9505. Li L, Shi C, Yin Z, et al. Antibacterial activity of α-terpineol may induce morphostructural alterations in Escherichia coli. Braz J Microbiol. 2015;45:1409-1413. Yoneda M, Naka S, Nakano K, et al. Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease. BMC Gastroenterol. 2012;12:16. Komazaki R, Katagiri S, Takahashi H, et al. Periodontal pathogenic bacteria, Aggregatibacter actinomycetemcomitans affect non-alcoholic fatty liver disease by altering gut microbiota and glucose metabolism. Sci Rep. 2017;1:13950. |
معلومات مُعتمدة: | PIBIC 2016/2017 Federal University; PIBIC 2017/2018 Federal University; PIBITI 2017/2018 Federal University; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 455104/2014-0 CNPq |
فهرسة مساهمة: | Keywords: alveolar bone loss; hepatocyte; liver; oral medicine; periodontal disease |
المشرفين على المادة: | 0 (Cyclohexane Monoterpenes) 0 (beta-Cyclodextrins) 21334LVV8W (alpha-terpineol) |
تواريخ الأحداث: | Date Created: 20200626 Date Completed: 20210118 Latest Revision: 20210118 |
رمز التحديث: | 20240628 |
DOI: | 10.1111/jre.12780 |
PMID: | 32583890 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1600-0765 |
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DOI: | 10.1111/jre.12780 |