دورية أكاديمية
Evaluation of Risk Factors for Development of Anti-Tubercular Therapy Induced Hepatotoxicity: A Prospective Study.
| العنوان: | Evaluation of Risk Factors for Development of Anti-Tubercular Therapy Induced Hepatotoxicity: A Prospective Study. |
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| المؤلفون: | Subbalaxmi MVS; Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad, India., Soanker R; Department of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad, India., Lakshmi AV; Department of General Medicine, Nizam's Institute of Medical Sciences, Hyderabad, India. |
| المصدر: | Current drug safety [Curr Drug Saf] 2020; Vol. 15 (3), pp. 198-204. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Saif Zone, Sharjah, U.A.E. Country of Publication: United Arab Emirates NLM ID: 101270895 Publication Model: Print Cited Medium: Internet ISSN: 2212-3911 (Electronic) Linking ISSN: 15748863 NLM ISO Abbreviation: Curr Drug Saf Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: San Francisco, CA : Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers, c2006- |
| مواضيع طبية MeSH: | Antitubercular Agents/*adverse effects , Chemical and Drug Induced Liver Injury/*epidemiology , Tuberculosis/*drug therapy, Adult ; Alcoholism/epidemiology ; Antitubercular Agents/administration & dosage ; Chemical and Drug Induced Liver Injury/etiology ; Female ; HIV Infections/epidemiology ; Humans ; Incidence ; India/epidemiology ; Liver Function Tests ; Longitudinal Studies ; Male ; Middle Aged ; Prospective Studies ; Risk Factors ; Sex Factors ; Tuberculosis, Pulmonary/drug therapy ; Young Adult |
| مستخلص: | Background: Incidence of Antitubercular Therapy (ATT)-induced hepatotoxicity is higher in India when compared to Western countries. As the occurrence of ATT-induced hepatotoxicity is unpredictable, serial intensive monitoring of hepatic function is now being recommended by the American Thoracic Society in individuals at high risk. This study was done to evaluate the risk factors for the development of ATT induced hepatotoxicity in India. Methodology: In this prospective, observational study, patient characteristics of microbiologically/ radiologically/ histopathologically confirmed tuberculosis were prospectively compiled. Serial liver function tests were done once a month in all patients. Patients who developed ATT-induced hepatotoxicity were considered as the study group and those who did not develop the event as a control group. The primary outcome measure was to estimate the hazard ratios associated with risk factors for the development of ATT induced hepatotoxicity. Cox Regression Analysis was done using SPSS 20. Results: A total of 200 patients were enrolled in the study, of them, 14% developed ATT-induced hepatotoxicity and 86% did not develop the event. The baseline liver function tests in the study group and control group were within normal limits. Female gender, alcoholism, HIV co-infection and age >35 yrs were identified to have a higher risk for development of ATT-induced hepatotoxicity, while cases with pulmonary tuberculosis were found to be at lower risk of developing event. Conclusion: Intensive liver function monitoring needs to be done in patients with these risk factors, female gender, alcoholism, HIV co-infection, extra-pulmonary tuberculosis and age >35 yrs. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
| فهرسة مساهمة: | Keywords: Adverse effects; anti-tubercular therapy; aspartate aminotransferase; hepatotoxicity; rechallenge; risk predictors |
| المشرفين على المادة: | 0 (Antitubercular Agents) |
| تواريخ الأحداث: | Date Created: 20200627 Date Completed: 20210805 Latest Revision: 20210805 |
| رمز التحديث: | 20221213 |
| DOI: | 10.2174/1574886315666200626164554 |
| PMID: | 32589563 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2212-3911 |
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| DOI: | 10.2174/1574886315666200626164554 |