دورية أكاديمية
Global molecular diversity of RSV - the "INFORM RSV" study.
| العنوان: | Global molecular diversity of RSV - the "INFORM RSV" study. |
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| المؤلفون: | Langedijk AC; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands., Lebbink RJ; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands., Naaktgeboren C; Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands., Evers A; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands., Viveen MC; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands., Greenough A; Department of Women and Children's Health, School of Life Course Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.; ReSViNET foundation, Zeist, the Netherlands., Heikkinen T; ReSViNET foundation, Zeist, the Netherlands.; Department of Paediatrics, University of Turku and Turku University Hospital, Turku, Finland., Stein RT; Centro INFANT at Pontificia Universidade Catolica de Rio Grande do Sul, Porto Alegre, Brazil., Richmond P; Department of Paediatrics, The University of Queensland, Brisbane, Australia., Martinón-Torres F; Department of Paediatrics, Hospital Clínico Universitario de Santiago, Santiago, Galicia, Spain., Nunes M; ReSViNET foundation, Zeist, the Netherlands.; Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.; Department of Science and Technology/National Research Foundation: Vaccine Preventable Diseases Unit, Faculty of health Sciences, University of the Witwatersrand, Johannesburg, South Africa., Hosoya M; Department of Paediatrics, Fukushima Medical University School of Medicine, Fukushima, Japan., Keller C; Department of Virology, University Hospital Giessen and Marburg, Marburg, Germany., Bauck M; Department of Paediatrics, University Hospital Giessen and Marburg, Marburg, Germany., Cohen R; Association Clinique et Thérapeutique Infantile du Val-de-Marne, CHI Créteil, GRC Gemini, Université Paris XII, Créteil, France., Papenburg J; Department of Paediatrics, Division of Pediatric Infectious Diseases, Montreal Children's Hospital, McGill University Health Centre, Montreal, Canada., Pernica J; Department of Paediatrics, McMaster University, Hamilton, Canada., Hennus MP; Paediatric Intensive Care Unit, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands., Jin H; AstraZeneca, Gaithersburg/South San Francisco, USA., Tabor DE; AstraZeneca, Gaithersburg/South San Francisco, USA., Tovchigrechko A; AstraZeneca, Gaithersburg/South San Francisco, USA., Ruzin A; AstraZeneca, Gaithersburg/South San Francisco, USA., Abram ME; AstraZeneca, Gaithersburg/South San Francisco, USA., Wilkins D; AstraZeneca, Gaithersburg/South San Francisco, USA., Wildenbeest JG; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands., Kragten-Tabatabaie L; ReSViNET foundation, Zeist, the Netherlands.; Julius Clinical, Zeist, the Netherlands., Coenjaerts FEJ; Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, the Netherlands., Esser MT; AstraZeneca, Gaithersburg/South San Francisco, USA., Bont LJ; Department of Paediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands. l.bont@umcutrecht.nl.; ReSViNET foundation, Zeist, the Netherlands. l.bont@umcutrecht.nl. |
| المصدر: | BMC infectious diseases [BMC Infect Dis] 2020 Jun 26; Vol. 20 (1), pp. 450. Date of Electronic Publication: 2020 Jun 26. |
| نوع المنشور: | Clinical Study; Journal Article; Multicenter Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : BioMed Central, [2001- |
| مواضيع طبية MeSH: | Genome, Viral* , Polymorphism, Genetic*, Molecular Epidemiology/*methods , Respiratory Syncytial Virus Infections/*epidemiology , Respiratory Syncytial Virus Infections/*prevention & control , Respiratory Syncytial Virus, Human/*genetics, Antibodies, Monoclonal/therapeutic use ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Child, Preschool ; Drug Resistance, Bacterial/genetics ; Female ; Genotype ; Humans ; Immunization, Passive ; Infant ; Infant, Newborn ; Male ; Prospective Studies ; Respiratory Syncytial Virus, Human/immunology ; Respiratory Syncytial Virus, Human/isolation & purification ; Reverse Transcriptase Polymerase Chain Reaction |
| مستخلص: | Background: Respiratory syncytial virus (RSV) is a global cause of severe respiratory morbidity and mortality in infants. While preventive and therapeutic interventions are being developed, including antivirals, vaccines and monoclonal antibodies, little is known about the global molecular epidemiology of RSV. INFORM is a prospective, multicenter, global clinical study performed by ReSViNET to investigate the worldwide molecular diversity of RSV isolates collected from children less than 5 years of age. Methods: The INFORM study is performed in 17 countries spanning all inhabited continents and will provide insight into the molecular epidemiology of circulating RSV strains worldwide. Sequencing of > 4000 RSV-positive respiratory samples is planned to detect temporal and geographical molecular patterns on a molecular level over five consecutive years. Additionally, RSV will be cultured from a subset of samples to study the functional implications of specific mutations in the viral genome including viral fitness and susceptibility to different monoclonal antibodies. Discussion: The sequencing and functional results will be used to investigate susceptibility and resistance to novel RSV preventive or therapeutic interventions. Finally, a repository of globally collected RSV strains and a database of RSV sequences will be created. |
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| معلومات مُعتمدة: | NA AstraZeneca |
| فهرسة مساهمة: | Keywords: Molecular epidemiology; Monoclonal antibodies; Next generation sequencing; Respiratory syncytial virus; Temporal and geographical diversity; Vaccines |
| المشرفين على المادة: | 0 (Antibodies, Monoclonal) 0 (Antiviral Agents) |
| تواريخ الأحداث: | Date Created: 20200628 Date Completed: 20200707 Latest Revision: 20200707 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7316634 |
| DOI: | 10.1186/s12879-020-05175-4 |
| PMID: | 32591017 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1471-2334 |
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| DOI: | 10.1186/s12879-020-05175-4 |