دورية أكاديمية
أعرض في EDS

Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial use for treatment of healthcare-associated infections and bacterial resistance in a reference neonatal unit.
المؤلفون: Silva ACBE; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Centro de Pós graduação, Belo Horizonte, MG, Brazil; Pontifícia Universidade Católica de Minas Gerais, Belo Horizonte, MG, Brazil. Electronic address: acbuenos@yahoo.com.br., Anchieta LM; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Pediatria, Belo Horizonte, MG, Brazil., Rosado V; Universidade Federal de Minas Gerais (UFMG), Hospital das Clínicas, Serviço de Controle de Infecção Hospitalar, Belo Horizonte, MG, Brazil., Ferreira J; Universidade Federal de Minas Gerais (UFMG), Hospital das Clínicas, Serviço de Controle de Infecção Hospitalar, Belo Horizonte, MG, Brazil., Clemente WT; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento Propedêutico, Belo Horizonte, MG, Brazil., Coelho JS; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Pediatria, Belo Horizonte, MG, Brazil., Mourão PHO; Universidade Federal de Minas Gerais (UFMG), Hospital das Clínicas, Serviço de Controle de Infecção Hospitalar, Belo Horizonte, MG, Brazil., Romanelli RMC; Universidade Federal de Minas Gerais (UFMG), Faculdade de Medicina, Departamento de Pediatria, Belo Horizonte, MG, Brazil.
المصدر: Jornal de pediatria [J Pediatr (Rio J)] 2021 May-Jun; Vol. 97 (3), pp. 329-334. Date of Electronic Publication: 2020 Jun 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Editora Ltda Country of Publication: Brazil NLM ID: 2985188R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4782 (Electronic) Linking ISSN: 00217557 NLM ISO Abbreviation: J Pediatr (Rio J) Subsets: MEDLINE
أسماء مطبوعة: Publication: Rio de Janeiro, Brazil : Elsevier Editora Ltda
Original Publication: Rio de Janeiro.
مواضيع طبية MeSH: Anti-Infective Agents* , Bacterial Infections*/drug therapy , Cross Infection*/drug therapy , Gram-Negative Bacterial Infections*/drug therapy, Anti-Bacterial Agents/therapeutic use ; Cohort Studies ; Delivery of Health Care ; Gram-Negative Bacteria ; Humans ; Infant, Newborn ; Microbial Sensitivity Tests
مستخلص: Objective: The use of broad-spectrum antimicrobials, such as third and fourth-generation, are responsible for emergence of multidrug-resistant microorganisms in neonatal units. Furthermore, antimicrobial daily doses are not standardized in neonatology. This study aimed to investigate the association between the use of antimicrobial broad spectrum to bacterial sensitivity profile in a referral unit of neonatal progressive care.
Methods: This is a cohort study conducted in a referral neonatal progressive care unit from January 2008 to December 2016. The data of all hospitalized neonates was collected daily. The infection criteria used were the standardized national criteria, based on definitions of Center for Diseases Control and Prevention. In this study, the use of antimicrobials was evaluated as antimicrobial-day (ATM-day) and the ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was also calculated. The study was approved by the Institutional Review Board of the Universidade Federal de Minas Gerais (ETIC 312/08 e CAAE 58973616.2.0000.5149).
Results: From 2008 to 2016, 2751 neonates were hospitalized, corresponding to 60,656 patient-days. The ratio of multidrug-resistant microorganisms per 1000 ATM-day of broad spectrum was 1,3 in the first period and 4,3 in the second period (p=0,005).
Conclusion: It was observed that use of broad-spectrum antimicrobials, especially those with coverage for Gram-negative bacteria, was associated with an increase of multidrug-resistant bacteria.
(Copyright © 2020 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.)
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فهرسة مساهمة: Keywords: Anti-infective agents; Drug resistance; Infant; Infection control; Microbial; Newborn
المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Anti-Infective Agents)
تواريخ الأحداث: Date Created: 20200628 Date Completed: 20210524 Latest Revision: 20220910
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC9432030
DOI: 10.1016/j.jped.2020.06.001
PMID: 32592659
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-4782
DOI:10.1016/j.jped.2020.06.001