دورية أكاديمية
Behçet's Disease Under Microbiotic Surveillance? A Combined Analysis of Two Cohorts of Behçet's Disease Patients.
| العنوان: | Behçet's Disease Under Microbiotic Surveillance? A Combined Analysis of Two Cohorts of Behçet's Disease Patients. |
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| المؤلفون: | van der Houwen TB; Section Clinical Immunology, Departments of Internal Medicine and Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands., van Laar JAM; Section Clinical Immunology, Departments of Internal Medicine and Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands., Kappen JH; Allergy and Clinical Immunology, Immunomodulation and Tolerance Group, Inflammation Repair and Development, Imperial College, National Heart and Lung Institute, London, United Kingdom.; Department of Pulmonology, STZ Centre of Excellence for Asthma and COPD, Franciscus Group, Rotterdam, United Kingdom., van Hagen PM; Section Clinical Immunology, Departments of Internal Medicine and Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands., de Zoete MR; Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands., van Muijlwijk GH; Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands., Berbers RM; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands., Fluit AC; Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands., Rogers M; Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands., Groot J; Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands., Hazelbag CM; Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands., Consolandi C; National Research Council, Institute of Biomedical Technologies, Segrate, Italy., Severgnini M; National Research Council, Institute of Biomedical Technologies, Segrate, Italy., Peano C; National Research Council, Institute of Genetic and Biomedical Research, UoS Milan, Milan, Italy.; Genomic Unit, Humanitas Clinical and Research Center, Milan, Italy., D'Elios MM; Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy., Emmi G; Department of Experimental and Clinical Medicine, University of Firenze, Firenze, Italy., Leavis HL; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, Netherlands. |
| المصدر: | Frontiers in immunology [Front Immunol] 2020 Jun 12; Vol. 11, pp. 1192. Date of Electronic Publication: 2020 Jun 12 (Print Publication: 2020). |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome*, Behcet Syndrome/*microbiology, Adult ; Aged ; Cohort Studies ; Female ; Humans ; Italy ; Male ; Middle Aged ; Netherlands |
| مستخلص: | Background: In Behçet's disease (BD), an auto-inflammatory vasculitis, an unbalanced gut microbiota can contribute to pro-inflammatory reactions. In separate studies, distinct pro- and anti-inflammatory bacteria associated with BD have been identified. Methods: To establish disease-associated determinants, we performed gut microbiome profiling in BD patients from the Netherlands ( n = 19) and Italy ( n = 13), matched healthy controls (HC) from the Netherlands ( n = 17) and Italy ( n = 15) and oral microbiome profiling in Dutch BD patients ( n = 18) and HC ( n = 15) by 16S rRNA gene sequencing. In addition, we used fecal IgA-SEQ analysis to identify specific IgA coated bacterial taxa in Dutch BD patients ( n = 13) and HC ( n = 8). Results: In BD stool samples alpha-diversity was conserved, whereas beta-diversity analysis showed no clustering based on disease, but a significant segregation by country of origin. Yet, a significant decrease of unclassified Barnesiellaceae and Lachnospira genera was associated with BD patients compared to HC. Subdivided by country, the Italian cohort displays a significant decrease of unclassified Barnesiellaceae and Lachnospira genera, in the Dutch cohort this decrease is only a trend. Increased IgA-coating of Bifidobacterium spp., Dorea spp. and Ruminococcus bromii species was found in stool from BD patients. Moreover, oral Dutch BD microbiome displayed increased abundance of Spirochaetaceae and Dethiosulfovibrionaceae families. Conclusions: BD patients show decreased fecal abundance of Barnesiellaceae and Lachnospira and increased oral abundance of Spirochaetaceae and Dethiosulfovibrionaceae . In addition, increased fecal IgA coating of Bifidobacterium, Ruminococcus bromii and Dorea may reflect retention of anti-inflammatory species and neutralization of pathosymbionts in BD, respectively. Additional studies are warranted to relate intestinal microbes with the significance of ethnicity, diet, medication and response with distinct pro- and inflammatory pathways in BD patients. (Copyright © 2020 van der Houwen, van Laar, Kappen, van Hagen, de Zoete, van Muijlwijk, Berbers, Fluit, Rogers, Groot, Hazelbag, Consolandi, Severgnini, Peano, D'Elios, Emmi and Leavis.) |
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| فهرسة مساهمة: | Keywords: Behçet's disease; IgA-SEQ; intestinal; microbiota; oral |
| تواريخ الأحداث: | Date Created: 20200630 Date Completed: 20210402 Latest Revision: 20210402 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7303268 |
| DOI: | 10.3389/fimmu.2020.01192 |
| PMID: | 32595645 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2020.01192 |