دورية أكاديمية
أعرض في EDS

Adaptation of rat fast-twitch muscle to endurance activity is underpinned by changes to protein degradation as well as protein synthesis.

التفاصيل البيبلوغرافية
العنوان: Adaptation of rat fast-twitch muscle to endurance activity is underpinned by changes to protein degradation as well as protein synthesis.
المؤلفون: Hesketh SJ; Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, Liverpool, UK., Sutherland H; Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, Liverpool, UK., Lisboa PJ; Department of Applied Mathematics, Liverpool John Moores University, Liverpool, UK., Jarvis JC; Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, Liverpool, UK., Burniston JG; Research Institute for Sport & Exercise Sciences, Liverpool John Moores University, Liverpool, UK.; Liverpool Centre for Cardiovascular Science, Liverpool John Moores University, Liverpool, UK.
المصدر: FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2020 Aug; Vol. 34 (8), pp. 10398-10417. Date of Electronic Publication: 2020 Jun 29.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Federation of American Societies for Experimental Biology Country of Publication: United States NLM ID: 8804484 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1530-6860 (Electronic) Linking ISSN: 08926638 NLM ISO Abbreviation: FASEB J Subsets: MEDLINE
أسماء مطبوعة: Publication: 2020- : [Bethesda, Md.] : Hoboken, NJ : Federation of American Societies for Experimental Biology ; Wiley
Original Publication: [Bethesda, Md.] : The Federation, [c1987-
مواضيع طبية MeSH: Adaptation, Physiological/*physiology , Muscle Fibers, Fast-Twitch/*physiology , Physical Conditioning, Animal/*physiology , Protein Biosynthesis/*physiology, Animals ; Electric Stimulation/methods ; Hindlimb/metabolism ; Hindlimb/physiology ; Male ; Muscle Fibers, Fast-Twitch/metabolism ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/physiology ; Proteolysis ; Proteome/metabolism ; Proteomics/methods ; Rats ; Rats, Wistar
مستخلص: Muscle adaptations to exercise are underpinned by alterations to the abundance of individual proteins, which may occur through a change either to the synthesis or degradation of each protein. We used deuterium oxide ( 2 H 2 O) labeling and chronic low-frequency stimulation (CLFS) in vivo to investigate the synthesis, abundance, and degradation of individual proteins during exercise-induced muscle adaptation. Independent groups of rats received CLFS (10 Hz, 24 h/d) and 2 H 2 O for 0, 10, 20, or 30 days. The extensor digitorum longus (EDL) was isolated from stimulated (Stim) and contralateral non-stimulated (Ctrl) legs. Proteomic analysis encompassed 38 myofibrillar and 46 soluble proteins and the rates of change in abundance, synthesis, and degradation were reported in absolute (ng/d) units. Overall, synthesis and degradation made equal contributions to the adaptation of the proteome, including instances where a decrease in protein-specific degradation primarily accounted for the increase in abundance of the protein.
(© 2020 The Authors. The FASEB Journal published by Wiley Periodicals LLC on behalf of Federation of American Societies for Experimental Biology.)
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فهرسة مساهمة: Keywords: biosynthetic labeling; chronic stimulation; deuterium oxide; protein degradation; protein synthesis
المشرفين على المادة: 0 (Proteome)
تواريخ الأحداث: Date Created: 20200630 Date Completed: 20210301 Latest Revision: 20210301
رمز التحديث: 20221213
DOI: 10.1096/fj.202000668RR
PMID: 32598083
قاعدة البيانات: MEDLINE
الوصف
تدمد:1530-6860
DOI:10.1096/fj.202000668RR