دورية أكاديمية
Anti-diabetic and lipid-lowering effects of drimane sesquiterpenoids isolated from Zygogynum pancheri.
| العنوان: | Anti-diabetic and lipid-lowering effects of drimane sesquiterpenoids isolated from Zygogynum pancheri. |
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| المؤلفون: | Belhadj S; Department of Biology, University of Bourgogne, France. Electronic address: belhadjsahla@hotmail.com., Keskes H; Laboratory of Organic Chemistry (LR17-ES08), Natural Substances Team, University of Sfax, Faculty of Sciences of Sfax, PB « 1171 », PC « 3000 », Sfax, Tunisia., Apel C; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France., Roussi F; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France., Litaudon M; Université Paris-Saclay, CNRS, Institut de Chimie des Substances Naturelles, UPR 2301, 91198, Gif-sur-Yvette, France., Hentati O; Institut Supérieur de Biotechnologie de Sfax, Route de Soukra, Km 4, BP 1175, 3038, Université de Sfax, Sfax, Tunisia; Laboratoire Génie Environnement et Ecotechnologie, Ecole Nationale d'Ingénieurs de Sfax (LGEET LR16ES19-ENIS), Route de Soukra, Km 4, BP 1173, 3038, Université de Sfax, Sfax, Tunisia., Allouche N; Laboratory of Organic Chemistry (LR17-ES08), Natural Substances Team, University of Sfax, Faculty of Sciences of Sfax, PB « 1171 », PC « 3000 », Sfax, Tunisia. |
| المصدر: | Chemico-biological interactions [Chem Biol Interact] 2020 Oct 01; Vol. 330, pp. 109167. Date of Electronic Publication: 2020 Jun 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Ireland NLM ID: 0227276 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7786 (Electronic) Linking ISSN: 00092797 NLM ISO Abbreviation: Chem Biol Interact Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Original Publication: Amsterdam, Elsevier. |
| مواضيع طبية MeSH: | Diabetes Mellitus, Experimental/*drug therapy , Phytotherapy/*methods , Plant Extracts/*pharmacology , Polycyclic Sesquiterpenes/*isolation & purification, Animals ; Anti-Obesity Agents/isolation & purification ; Anti-Obesity Agents/pharmacology ; Hypoglycemic Agents/isolation & purification ; Hypoglycemic Agents/pharmacology ; Hypolipidemic Agents/isolation & purification ; Hypolipidemic Agents/pharmacology ; Male ; New Caledonia ; Plant Extracts/chemistry ; Polycyclic Sesquiterpenes/pharmacology ; Rats ; Rats, Wistar ; Sesquiterpenes/isolation & purification ; Sesquiterpenes/pharmacology ; Winteraceae/chemistry |
| مستخلص: | Recently, it has been shown that drimane-type sesquiterpenoids isolated from Zygogynum pancheri, a species native to New Caledonia, possessed significant α-amylase inhibitory activities. To further explore their antidiabetic potential, we investigated the effect of 1β-O-(E-cinnamoyl)-6α-hydroxy-9epi-polygodial (D) and 1β-E-O-p-methoxycinnamoyl-bemadienolide (L), two of the most active compounds of the series, on diabetic model rats. Compounds D and L (2 mg kg/day) were daily and orally administrated for 30 days to streptozotocin (STZ) (150 mg/kg) induced male diabetic Wistar rats. Animals were allocated into five groups of six rats. Comparatively to diabetic rats, treatments with D and L compounds were able to significantly (P < 0.05) decrease Fasting Blood Glucose (FBG) (70.15%, 71.02%), serum total cholesterol (46.27% and 39.38%), triglycerides (56.60% and 58.15%), creatinine (37.31% and 36.49%) and uric acid levels (67.76% and 69.68%), respectively. Compounds D and L also restored the altered plasma enzyme (aspartate aminotransferase, AST (47.83% and 43.20%), alanine aminotransferase, ALT (49.76% and 48.35%, alkaline phosphatase, ALP (72.78% and 73.21%)) and lactate dehydrogenase, LDH (47.95% and 53.93%) levels to near normal, respectively. Administration of Glymepiride, significantly (p < 0.05) reduced FBG (73.94%) in STZ induced diabetic rats. Additionally, the compounds D and L exhibited inhibitory effects in vivo on lipase activity of diabetic rats (54.83% and 52.25%), respectively. The outcomes of this study suggested that these two drimanes could be considered as efficient hypoglycemic, hypolipidemic and antiobesity agents for diabetes management and its complications. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Hypoglycemia; Hypolipidemia; Streptozotocin; Winteraceae; Zygogynum pancheri subsp. arrhantum |
| المشرفين على المادة: | 0 (Anti-Obesity Agents) 0 (Hypoglycemic Agents) 0 (Hypolipidemic Agents) 0 (Plant Extracts) 0 (Polycyclic Sesquiterpenes) 0 (Sesquiterpenes) 0 (drimane) 5FAF7T66M7 (polygodial) |
| تواريخ الأحداث: | Date Created: 20200701 Date Completed: 20201014 Latest Revision: 20201014 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.cbi.2020.109167 |
| PMID: | 32603660 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7786 |
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| DOI: | 10.1016/j.cbi.2020.109167 |