دورية أكاديمية
Metformin Use Is Associated with a Lower Risk of Inflammatory Bowel Disease in Patients with Type 2 Diabetes Mellitus.
| العنوان: | Metformin Use Is Associated with a Lower Risk of Inflammatory Bowel Disease in Patients with Type 2 Diabetes Mellitus. |
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| المؤلفون: | Tseng CH; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Division of Environmental Health and Occupational Medicine of the National Health Research Institutes, Zhunan, Taiwan. |
| المصدر: | Journal of Crohn's & colitis [J Crohns Colitis] 2021 Jan 13; Vol. 15 (1), pp. 64-73. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 101318676 Publication Model: Print Cited Medium: Internet ISSN: 1876-4479 (Electronic) Linking ISSN: 18739946 NLM ISO Abbreviation: J Crohns Colitis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Oxford : Oxford University Press Original Publication: Amsterdam : Elsevier Science |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/drug therapy , Dose-Response Relationship, Drug* , Inflammatory Bowel Diseases*/diagnosis , Inflammatory Bowel Diseases*/epidemiology , Inflammatory Bowel Diseases*/prevention & control, Metformin/*therapeutic use, Aged ; Databases, Factual/statistics & numerical data ; Duration of Therapy ; Female ; Humans ; Hypoglycemic Agents/classification ; Hypoglycemic Agents/therapeutic use ; Incidence ; Insulin/therapeutic use ; Male ; Middle Aged ; Risk Assessment ; Taiwan/epidemiology |
| مستخلص: | Aim: Our aim was to compare the risk of developing inflammatory bowel disease [IBD] between ever users and never users of metformin. Methods: Patients with newly diagnosed type 2 diabetes mellitus from 1999 to 2005 were enrolled from Taiwan's National Health Insurance. A total of 340 211 ever users and 24 478 never users who were free from IBD on January 1, 2006 were followed up until December 31, 2011. Hazard ratios were estimated by Cox regression incorporating the inverse probability of treatment weighting using a propensity score. Results: New-onset IBD was diagnosed in 6466 ever users and 750 never users. The respective incidence rates were 412.0 and 741.3 per 100 000 person-years and the hazard ratio for ever vs never users was 0.55 [95% confidence interval: 0.51-0.60]. A dose-response pattern was observed while comparing the tertiles of cumulative duration of metformin therapy to never users. The respective hazard ratios for the first [<26.0 months], second [26.0-58.3 months] and third [>58.3 months] tertiles were 1.00 [0.93-1.09], 0.57 [0.52-0.62] and 0.24 [0.22-0.26]. While patients treated with oral antidiabetic drugs [OADs] without metformin were treated as a reference group, the hazard ratios for patients treated with OADs with metformin, with insulin without metformin [with/without other OADs] and with insulin and metformin [with/without other OADs] were 0.52 [0.42-0.66], 0.95 [0.76-1.20] and 0.50 [0.40-0.62], respectively. Conclusion: A reduced risk of IBD is consistently observed in patients with type 2 diabetes mellitus who have been treated with metformin. (© The Author(s) 2020. Published by Oxford University Press on behalf of European Crohn’s and Colitis Organisation. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: Crohn’s disease; Inflammatory bowel disease; Taiwan; metformin; ulcerative colitis |
| المشرفين على المادة: | 0 (Hypoglycemic Agents) 0 (Insulin) 9100L32L2N (Metformin) |
| تواريخ الأحداث: | Date Created: 20200701 Date Completed: 20211013 Latest Revision: 20211013 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1093/ecco-jcc/jjaa136 |
| PMID: | 32604412 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1876-4479 |
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| DOI: | 10.1093/ecco-jcc/jjaa136 |