دورية أكاديمية
أعرض في EDS

Açaí seed extract prevents the renin-angiotensin system activation, oxidative stress and inflammation in white adipose tissue of high-fat diet-fed mice.

التفاصيل البيبلوغرافية
العنوان: Açaí seed extract prevents the renin-angiotensin system activation, oxidative stress and inflammation in white adipose tissue of high-fat diet-fed mice.
المؤلفون: Santos IB; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: izabellebarcellos@hotmail.com., de Bem GF; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: graziuerj@yahoo.com.br., da Costa CA; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: crysac84@yahoo.com.br., de Carvalho LCRM; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: lenizereis@gmail.com., de Medeiros AF; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: medeirosamanda15@gmail.com., Silva DLB; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: dafnelopes.bs@gmail.com., Romão MH; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: metheus.henrique.r@hotmail.com., de Andrade Soares R; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: r.andrade.soares.bio@gmail.com., Ognibene DT; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: dayognibene@gmail.com., de Moura RS; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: robertosoaresdemoura@gmail.com., Resende AC; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: angelaresende.uerj@gmail.com.
المصدر: Nutrition research (New York, N.Y.) [Nutr Res] 2020 Jul; Vol. 79, pp. 35-49. Date of Electronic Publication: 2020 May 21.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8303331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0739 (Electronic) Linking ISSN: 02715317 NLM ISO Abbreviation: Nutr Res Subsets: MEDLINE
أسماء مطبوعة: Publication: <2004- > : Tarrytown, NY : Elsevier Science
Original Publication: New York : Pergamon Press, c1981-
مواضيع طبية MeSH: Diet, High-Fat* , Euterpe* , Oxidative Stress*/drug effects, Adipose Tissue, White/*metabolism , Plant Extracts/*pharmacology , Renin-Angiotensin System/*physiology, Adipocytes/drug effects ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Adipose Tissue, White/drug effects ; Angiotensin-Converting Enzyme Inhibitors/pharmacology ; Animals ; Blood Glucose/analysis ; Blood Pressure/drug effects ; Body Weight/drug effects ; Eating/drug effects ; Enalapril/pharmacology ; Energy Intake/drug effects ; Inflammation ; Insulin/blood ; Lipids/blood ; Male ; Mice ; Mice, Inbred C57BL ; Renin-Angiotensin System/drug effects ; Seeds
مستخلص: The role of the renin-angiotensin system (RAS), oxidative stress, and inflammation on the development of obesity and its comorbidities has been extensively addressed. Euterpe oleracea Mart. (açaí) seed extract (ASE), with antioxidant and anti-inflammatory properties and capable to modulate plasma renin levels, has been evidenced as a potential regulator of body mass. We hypothesized that the supplementation with ASE might exert beneficial effects on obesity-related white adipose tissue changes and metabolic disorders by interfering with the local adipose tissue overexpression of RAS, inflammation, and oxidative stress in C57BL/6 mice fed a high-fat (HF) diet. The animals were fed a standard diet (10% fat, control), 60% fat (HF), HF + ASE (300 mg/kg per day) and HF + ENA (enalapril, 30 mg/kg per day) for 12 weeks. ASE and ENA prevented weight gain and adiposity, adipocyte hypertrophy, dyslipidemia, and insulin resistance. In adipose tissue, ASE increased the insulin receptor expression and reduced renin and AT1 receptor expression, which was associated with decreased plasma levels of renin and angiotensin II. Differently, ENA increased the expression of angiotensin-conversing enzyme 2, AT2, B2, and Mas receptors in adipose tissue. Also, ASE but not ENA decreased malondialdehyde and 8-isoprostane levels in adipose tissue. Finally, ASE and ENA reduced the adipose tissue inflammatory markers tumor necrosis factor alpha and interleukin 6. These results demonstrate that ASE prevented the adipocyte hypertrophy, obesity, hyperlipidemia, hyperglycemia, and insulin resistance in HF diet-fed mice. The downregulation of RAS in adipose tissue, reducing oxidative stress and inflammation, may contribute to the prevention of obesity-related disorders.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Adipose tissue; Angiotensin II; Euterpe oleracea Mart.; Obesity; Polyphenols
المشرفين على المادة: 0 (Angiotensin-Converting Enzyme Inhibitors)
0 (Blood Glucose)
0 (Insulin)
0 (Lipids)
0 (Plant Extracts)
69PN84IO1A (Enalapril)
تواريخ الأحداث: Date Created: 20200702 Date Completed: 20210618 Latest Revision: 20210618
رمز التحديث: 20231215
DOI: 10.1016/j.nutres.2020.05.006
PMID: 32610256
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-0739
DOI:10.1016/j.nutres.2020.05.006