دورية أكاديمية
Dental implants as risk factors for patients with medication-related osteonecrosis of the jaws (MRONJ).
| العنوان: | Dental implants as risk factors for patients with medication-related osteonecrosis of the jaws (MRONJ). |
|---|---|
| المؤلفون: | Pichardo SEC; Department of Oral & Maxillofacial Surgery (Chair: Prof. Dr. JPR van Merkesteyn), Leiden University Medical Center, PO BOX 9600, 2300 RC Leiden, The Netherlands; Center for Bone Quality Leiden, Leiden University Medical Center, PO BOX 9600, 2300 RC Leiden, The Netherlands., van der Hee JG; Department of Oral & Maxillofacial Surgery (Chair: Prof. Dr. JPR van Merkesteyn), Leiden University Medical Center, PO BOX 9600, 2300 RC Leiden, The Netherlands., Fiocco M; Department of Biomedical Data Sciences, Leiden University Medical Center, P.O. Box 9512, 2300 RA Leiden, The Netherlands; Mathematical Institute, Leiden University, P.O. Box 9512, 2300 RA Leiden, Leiden The Netherlands., Appelman-Dijkstra NM; Department of Internal Medicine, Leiden University Medical Center, PO BOX 9600, 2300 RC Leiden, The Netherlands; Center for Bone Quality Leiden, Leiden University Medical Center, PO BOX 9600, 2300 RC Leiden, The Netherlands., van Merkesteyn JPR; Department of Oral & Maxillofacial Surgery (Chair: Prof. Dr. JPR van Merkesteyn), Leiden University Medical Center, PO BOX 9600, 2300 RC Leiden, The Netherlands; Center for Bone Quality Leiden, Leiden University Medical Center, PO BOX 9600, 2300 RC Leiden, The Netherlands. Electronic address: j.p.r.van_merkesteyn@lumc.nl. |
| المصدر: | The British journal of oral & maxillofacial surgery [Br J Oral Maxillofac Surg] 2020 Sep; Vol. 58 (7), pp. 771-776. Date of Electronic Publication: 2020 Jul 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Churchill Livingstone Country of Publication: Scotland NLM ID: 8405235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-1940 (Electronic) Linking ISSN: 02664356 NLM ISO Abbreviation: Br J Oral Maxillofac Surg Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Edinburgh, U.K. : Churchill Livingstone, c1984- |
| مواضيع طبية MeSH: | Bisphosphonate-Associated Osteonecrosis of the Jaw* , Bone Density Conservation Agents* , Dental Implants*, Diphosphonates ; Humans ; Retrospective Studies ; Risk Factors |
| مستخلص: | An increasing number of patients with medication-related osteonecrosis of the jaws (MRONJ) has recently been reported. It is still being debated whether the presence or placement of dental implants can lead to MRONJ, so the aim of this study was to find out whether dental implants are a risk factor for MRONJ. From January 2003-January 2019 180 patients with MRONJ were seen at the Leiden University Medical Center. Luxating moments for the onset of MRONJ were calculated retrospectively. We collected clinical data and details of antiresorptive medication and found 22 patients with both dental implants and MRONJ. In 18 patients the implants were in the region of the MRONJ and they were included in this study, 14 who had had implants before using antiresorptive drugs and four who had had antiresorptive drugs before or at the time that the implants were placed. The median times between the placement of implants and the diagnosis of MRONJ in these two groups were 24 months and 6 months, respectively. Among the 47 implants, 30 were located in the necrotic region, and all 30 were either lost spontaneously or had to be removed during treatment of MRONJ. Our results show an increased risk for developing MRONJ in patients with dental implants. Both peri-implantitis around previously placed implants, and insertion of dental implants, are risk factors. Prevention of peri-implantitis and caution when inserting dental implants in patients who take antiresorptive medication are therefore important. (Copyright © 2020 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: BRONJ; DRONJ; Dental implants; MRONJ; bisphosphonates; denosumab; osteomyelitis; osteonecrosis; risk factor |
| المشرفين على المادة: | 0 (Bone Density Conservation Agents) 0 (Dental Implants) 0 (Diphosphonates) |
| تواريخ الأحداث: | Date Created: 20200708 Date Completed: 20201204 Latest Revision: 20201214 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.bjoms.2020.03.022 |
| PMID: | 32631756 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1532-1940 |
|---|---|
| DOI: | 10.1016/j.bjoms.2020.03.022 |