دورية أكاديمية
أعرض في EDS

T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria.

التفاصيل البيبلوغرافية
العنوان: T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria.
المؤلفون: Carpio VH; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-0435, USA., Aussenac F; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0435, USA., Puebla-Clark L; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0435, USA., Wilson KD; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-0435, USA., Villarino AV; Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Metabolic, and Skin Diseases, National Institutes of Health, Bethesda, MD 20892-1674, USA., Dent AL; Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA., Stephens R; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-0435, USA; Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, Galveston, TX 77555-0435, USA. Electronic address: rostephe@utmb.edu.
المصدر: IScience [iScience] 2020 Jul 24; Vol. 23 (7), pp. 101310. Date of Electronic Publication: 2020 Jun 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, [2018]-
مستخلص: Hybrid Th1/Tfh cells (IFN-γ + IL-21 + CXCR5 + ) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ + T cells control parasitemia, whereas antibody and IL-21 + Bcl6 + T cells effect final clearance, suggesting an evolutionary driver for the hybrid population. We found that CD4-intrinsic Bcl6, Blimp-1, and STAT3 coordinately regulate expression of the Th1 master regulator T-bet, supporting plasticity of CD4 T cells. Bcl6 and Blimp-1 regulate CXCR5 levels, and T-bet, IL-27Rα, and STAT3 modulate cytokines in hybrid Th1/Tfh cells. Infected mice with STAT3 knockout (KO) T cells produced less antibody and more Th1-like IFN-γ + IL-21 - CXCR5 lo effector and memory cells and were protected from re-infection. Conversely, T-bet KO mice had reduced Th1-bias upon re-infection and prolonged secondary parasitemia. Therefore, each feature of the CD4 T cell population phenotype is uniquely regulated in this persistent infection, and the cytokine profile of memory T cells can be modified to enhance the effectiveness of the secondary response.
Competing Interests: Declaration of Interests The authors declare no competing interests.
(Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
References: J Immunol. 2015 Jun 1;194(11):5346-54. (PMID: 25911759)
Sci Rep. 2019 Sep 30;9(1):13991. (PMID: 31570752)
Cell Rep. 2017 Nov 14;21(7):1839-1852. (PMID: 29141217)
Immunity. 2011 Dec 23;35(6):919-31. (PMID: 22195747)
Clin Microbiol Rev. 1998 Oct;11(4):569-88. (PMID: 9767056)
Infect Immun. 1999 Sep;67(9):4435-42. (PMID: 10456884)
Curr Opin Immunol. 2014 Jun;28:49-57. (PMID: 24594518)
PLoS Pathog. 2016 Oct 12;12(10):e1005945. (PMID: 27732671)
J Exp Med. 2011 May 9;208(5):1001-13. (PMID: 21518797)
J Immunol. 2013 Nov 1;191(9):4699-708. (PMID: 24078698)
J Immunol. 2016 Jan 15;196(2):778-91. (PMID: 26667167)
PLoS One. 2013;8(1):e55195. (PMID: 23383106)
Immunity. 2008 Jul 18;29(1):138-49. (PMID: 18599325)
Cell. 2013 May 9;153(4):785-96. (PMID: 23663778)
Cell Rep. 2019 Nov 19;29(8):2257-2269.e6. (PMID: 31747599)
J Immunol. 1999 May 1;162(9):5407-16. (PMID: 10228018)
EBioMedicine. 2017 Oct;24:216-230. (PMID: 28888925)
J Infect Dis. 2013 Jul;208(1):149-58. (PMID: 23539744)
J Infect Dis. 2000 Nov;182(5):1570-3. (PMID: 11023485)
Immunity. 2014 Oct 16;41(4):529-42. (PMID: 25367570)
J Exp Med. 2010 Dec 20;207(13):2895-906. (PMID: 21098093)
J Immunol. 2002 Feb 1;168(3):1348-55. (PMID: 11801675)
Blood. 2005 Sep 1;106(5):1676-84. (PMID: 15890689)
Science. 2009 Aug 21;325(5943):1001-5. (PMID: 19628815)
PLoS One. 2016 Jan 19;11(1):e0147356. (PMID: 26785168)
Sci Transl Med. 2013 Mar 13;5(176):176ra32. (PMID: 23486778)
Immunity. 2011 Oct 28;35(4):583-95. (PMID: 22018468)
Immunol Rev. 2020 Jan;293(1):88-114. (PMID: 31903675)
J Exp Med. 2018 Nov 5;215(11):2705-2714. (PMID: 30232200)
J Immunol. 2011 Dec 1;187(11):5568-76. (PMID: 22043009)
Immunity. 2009 Aug 21;31(2):209-19. (PMID: 19646904)
J Immunol. 2008 Aug 15;181(4):2338-47. (PMID: 18684923)
Science. 2009 Jun 19;324(5934):1569-72. (PMID: 19423777)
Immunol Cell Biol. 2014 Jan;92(1):34-9. (PMID: 24080769)
Science. 2010 Feb 26;327(5969):1098-102. (PMID: 20185720)
Science. 2009 Aug 21;325(5943):1006-10. (PMID: 19608860)
Infect Immun. 2014 Jan;82(1):10-20. (PMID: 24101691)
PLoS Pathog. 2010 Nov 24;6(11):e1001208. (PMID: 21124875)
Infect Immun. 2012 Dec;80(12):4248-56. (PMID: 23006847)
Front Immunol. 2018 Oct 15;9:2277. (PMID: 30374346)
Science. 1993 Apr 23;260(5107):547-9. (PMID: 8097338)
Immunity. 2009 May;30(5):673-83. (PMID: 19409816)
Nat Immunol. 2007 Dec;8(12):1363-71. (PMID: 17994025)
J Immunol. 2017 Jan 15;198(2):617-622. (PMID: 27940658)
Nat Immunol. 2012 Mar 11;13(4):405-11. (PMID: 22406686)
Trends Parasitol. 2012 Feb;28(2):73-82. (PMID: 22100995)
J Immunol. 2012 Feb 1;188(3):1178-90. (PMID: 22205023)
PLoS Pathog. 2016 Jan 14;12(1):e1005398. (PMID: 26765224)
J Immunol. 2000 Jul 1;165(1):389-96. (PMID: 10861076)
PLoS Pathog. 2015 Mar 12;11(3):e1004715. (PMID: 25763578)
Mol Biochem Parasitol. 2004 Jan;133(1):27-35. (PMID: 14668009)
J Immunol. 2015 Sep 1;195(5):2080-9. (PMID: 26188063)
Cell Rep. 2015 Oct 13;13(2):425-39. (PMID: 26440897)
Infect Immun. 2000 Aug;68(8):4399-406. (PMID: 10899836)
Immunity. 2009 Sep 18;31(3):457-68. (PMID: 19631565)
PLoS One. 2015 Dec 08;10(12):e0144654. (PMID: 26646149)
J Interferon Cytokine Res. 2003 Sep;23(9):513-22. (PMID: 14565860)
J Infect Dis. 1999 Apr;179(4):980-8. (PMID: 10068595)
Cell Host Microbe. 2010 Aug 19;8(2):163-73. (PMID: 20709293)
J Exp Med. 2018 Jan 2;215(1):337-355. (PMID: 29212666)
Infect Immun. 2003 Sep;71(9):4850-6. (PMID: 12933825)
Trends Immunol. 2014 Oct 22;35(12):591-596. (PMID: 25457838)
Cell Rep. 2016 Jan 5;14(1):68-81. (PMID: 26725120)
Immunity. 2014 Mar 20;40(3):367-77. (PMID: 24631156)
J Exp Med. 2011 May 9;208(5):987-99. (PMID: 21536743)
J Immunol. 2013 Apr 1;190(7):3049-53. (PMID: 23447690)
Immunity. 2013 Apr 18;38(4):805-17. (PMID: 23583644)
J Clin Invest. 2014 Aug;124(8):3455-68. (PMID: 25003188)
Cell. 2000 Mar 17;100(6):655-69. (PMID: 10761931)
J Exp Med. 2012 Mar 12;209(3):597-606. (PMID: 22370719)
Eur J Immunol. 1991 Jun;21(6):1433-8. (PMID: 1675172)
Nat Immunol. 2007 Apr;8(4):369-77. (PMID: 17351619)
Pharmacol Res Perspect. 2014 Dec;2(6):e00066. (PMID: 25505612)
Immunity. 2016 Mar 15;44(3):672-682. (PMID: 26968425)
Sci Immunol. 2017 Mar 3;2(9):. (PMID: 28345074)
Parasite Immunol. 2017 Oct;39(10):. (PMID: 28748530)
Blood. 2012 Apr 26;119(17):3997-4008. (PMID: 22403255)
Nat Immunol. 2002 Jun;3(6):549-57. (PMID: 12006974)
Immunity. 2014 Feb 20;40(2):289-302. (PMID: 24530057)
معلومات مُعتمدة: R01 AI089953 United States AI NIAID NIH HHS; R01 AI135061 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Immunology; Parasitology
تواريخ الأحداث: Date Created: 20200708 Latest Revision: 20210110
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7339051
DOI: 10.1016/j.isci.2020.101310
PMID: 32634740
قاعدة البيانات: MEDLINE
الوصف
تدمد:2589-0042
DOI:10.1016/j.isci.2020.101310