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IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection.

التفاصيل البيبلوغرافية
العنوان: IL-17A both initiates, via IFNγ suppression, and limits the pulmonary type-2 immune response to nematode infection.
المؤلفون: Ajendra J; Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Wellcome Centre for Cell-Matrix Research, Manchester, M13 9PT, UK., Chenery AL; Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Wellcome Centre for Cell-Matrix Research, Manchester, M13 9PT, UK., Parkinson JE; Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Wellcome Centre for Cell-Matrix Research, Manchester, M13 9PT, UK., Chan BHK; Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Wellcome Centre for Cell-Matrix Research, Manchester, M13 9PT, UK., Pearson S; Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Wellcome Centre for Cell-Matrix Research, Manchester, M13 9PT, UK., Colombo SAP; Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Wellcome Centre for Cell-Matrix Research, Manchester, M13 9PT, UK.; Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, L3 5QA, UK., Boon L; Bioceros, Member of Polpharma Biologics, Yalelaan 46, 3584, CM, Utrecht, The Netherlands., Grencis RK; Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Wellcome Centre for Cell-Matrix Research, Manchester, M13 9PT, UK., Sutherland TE; Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. tara.sutherland@manchester.ac.uk., Allen JE; Lydia Becker Institute for Immunology & Infection, Faculty of Biology, Medicine & Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK. judi.allen@manchester.ac.uk.; Wellcome Centre for Cell-Matrix Research, Manchester, M13 9PT, UK. judi.allen@manchester.ac.uk.
المصدر: Mucosal immunology [Mucosal Immunol] 2020 Nov; Vol. 13 (6), pp. 958-968. Date of Electronic Publication: 2020 Jul 07.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 101299742 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1935-3456 (Electronic) Linking ISSN: 19330219 NLM ISO Abbreviation: Mucosal Immunol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [New York, NY] : Elsevier
Original Publication: New York, NY : Nature Pub. Group, c2008-
مواضيع طبية MeSH: Interleukin-17/*metabolism , Lung/*immunology , Nippostrongylus/*physiology , Strongylida Infections/*immunology , Th2 Cells/*immunology, Animals ; Cells, Cultured ; Female ; Immune Tolerance ; Immunity, Innate ; Interferon-gamma/metabolism ; Interleukin-17/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
مستخلص: Nippostrongylus brasiliensis is a well-defined model of type-2 immunity but the early lung-migrating phase is dominated by innate IL-17A production. In this study, we confirm previous observations that Il17a-KO mice infected with N. brasiliensis exhibit an impaired type-2 immune response. Transcriptional profiling of the lung on day 2 of N. brasiliensis infection revealed an increased Ifng signature in Il17a-KO mice confirmed by enhanced IFNγ protein production in lung lymphocyte populations. Depletion of early IFNγ rescued type-2 immune responses in the Il17a-KO mice demonstrating that IL-17A-mediated suppression of IFNγ promotes type-2 immunity. Notably, later in infection, once the type-2 response was established, IL-17A limited the magnitude of the type-2 response. IL-17A regulation of type-2 immunity was lung-specific and infection with Trichuris muris revealed that IL-17A promotes a type-2 immune response in the lung even when infection is restricted to the intestine. Together our data reveal IL-17A as a major regulator of pulmonary type-2 immunity such that IL-17A supports early development of a protective type-2 response by suppression of IFNγ but subsequently limits excessive type-2 responses. A failure of this feedback loop may contribute to conditions such as severe asthma, characterised by combined elevation of IL-17 and type-2 cytokines.
التعليقات: Comment in: Mucosal Immunol. 2020 Nov;13(6):849-851. (PMID: 32728131)
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معلومات مُعتمدة: MR/K01207X/2 United Kingdom MRC_ Medical Research Council; 103132/Z/13/Z United Kingdom WT_ Wellcome Trust; MR/K01207X/1 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust; 106898/A/15/Z United Kingdom WT_ Wellcome Trust; Z10661/Z/18/Z United Kingdom WT_ Wellcome Trust; MRFAUK-2015-302 United Kingdom MRC_ Medical Research Council; MRF_MRF-009-0002-RG-SUTHE United Kingdom MRF MRF
المشرفين على المادة: 0 (Interleukin-17)
82115-62-6 (Interferon-gamma)
تواريخ الأحداث: Date Created: 20200709 Date Completed: 20210712 Latest Revision: 20240306
رمز التحديث: 20240306
مُعرف محوري في PubMed: PMC7567645
DOI: 10.1038/s41385-020-0318-2
PMID: 32636457
قاعدة البيانات: MEDLINE
الوصف
تدمد:1935-3456
DOI:10.1038/s41385-020-0318-2