دورية أكاديمية
أعرض في EDS

Low IgA Associated With Oropharyngeal Microbiota Changes and Lung Disease in Primary Antibody Deficiency.

التفاصيل البيبلوغرافية
العنوان: Low IgA Associated With Oropharyngeal Microbiota Changes and Lung Disease in Primary Antibody Deficiency.
المؤلفون: Berbers RM; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., Mohamed Hoesein FAA; Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., Ellerbroek PM; Department of Internal Medicine and Infectious Diseases, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., van Montfrans JM; Department of Paediatric Immunology and Infectious Diseases, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., Dalm VASH; Division of Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands.; Academic Center for Rare Immunological Diseases (RIDC), Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands., van Hagen PM; Division of Clinical Immunology, Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands.; Department of Immunology, Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands.; Academic Center for Rare Immunological Diseases (RIDC), Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands., Paganelli FL; Department of Medical Microbiology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., Viveen MC; Department of Medical Microbiology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., Rogers MRC; Department of Medical Microbiology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., de Jong PA; Department of Radiology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., Uh HW; Department of Biostatistics and Research Support, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., Willems RJL; Department of Medical Microbiology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands., Leavis HL; Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht and Utrecht University, Utrecht, Netherlands.
المصدر: Frontiers in immunology [Front Immunol] 2020 Jun 19; Vol. 11, pp. 1245. Date of Electronic Publication: 2020 Jun 19 (Print Publication: 2020).
نوع المنشور: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Immunoglobulin A/*immunology , Immunologic Deficiency Syndromes/*complications , Immunologic Deficiency Syndromes/*immunology , Lung Diseases/*immunology , Oropharynx/*microbiology, Adolescent ; Adult ; Child ; Cross-Sectional Studies ; Female ; Humans ; Immunoglobulin A/blood ; Male ; Young Adult
مستخلص: Common Variable Immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA) are primary antibody deficiencies characterized by hypogammaglobulinemia and recurrent infections, which can lead to structural airway disease (AD) and interstitial lung disease (ILD). We investigated associations between serum IgA, oropharyngeal microbiota composition and severity of lung disease in these patients. In this cross-sectional multicentre study we analyzed oropharyngeal microbiota composition of 86 CVID patients, 12 XLA patients and 49 healthy controls (HC) using next-generation sequencing of the 16S rRNA gene. qPCR was used to estimate bacterial load. IgA was measured in serum. High resolution CT scans were scored for severity of AD and ILD. Oropharyngeal bacterial load was increased in CVID patients with low IgA ( p = 0.013) and XLA ( p = 0.029) compared to HC. IgA status was associated with distinct beta (between-sample) diversity ( p = 0.039), enrichment of ( Allo)prevotella , and more severe radiographic lung disease ( p = 0.003), independently of recent antibiotic use. AD scores were positively associated with Prevotella, Alloprevotella , and Selenomonas , and ILD scores with Streptococcus and negatively with Rothia . In clinically stable patients with CVID and XLA, radiographic lung disease was associated with IgA deficiency and expansion of distinct oropharyngeal bacterial taxa. Our findings highlight IgA as a potential driver of upper respiratory tract microbiota homeostasis.
(Copyright © 2020 Berbers, Mohamed Hoesein, Ellerbroek, van Montfrans, Dalm, van Hagen, Paganelli, Viveen, Rogers, de Jong, Uh, Willems and Leavis.)
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فهرسة مساهمة: Keywords: CVID; XLA; immunoglobulin A; lung disease; microbiota; oropharyngeal
المشرفين على المادة: 0 (Immunoglobulin A)
تواريخ الأحداث: Date Created: 20200709 Date Completed: 20210405 Latest Revision: 20210405
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7318304
DOI: 10.3389/fimmu.2020.01245
PMID: 32636843
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2020.01245