دورية أكاديمية
أعرض في EDS

Gliomas display distinct sex-based differential methylation patterns based on molecular subtype.

التفاصيل البيبلوغرافية
العنوان: Gliomas display distinct sex-based differential methylation patterns based on molecular subtype.
المؤلفون: Johansen ML; Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Stetson LC; Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Vadmal V; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA., Waite K; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Cleveland Center for Health Outcomes Research, Cleveland, Ohio, USA., Berens ME; Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, Arizona, USA., Connor JR; Department of Neurosurgery, Penn State College of Medicine, Hershey, Pennsylvania, USA., Lathia J; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA., Rubin JB; Departments of Pediatrics and Neuroscience, Washington University School of Medicine, St. Louis, Missouri, USA., Barnholtz-Sloan JS; Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.; Cleveland Center for Health Outcomes Research, Cleveland, Ohio, USA.
المصدر: Neuro-oncology advances [Neurooncol Adv] 2020 Jan 08; Vol. 2 (1), pp. vdaa002. Date of Electronic Publication: 2020 Jan 08 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101755003 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-2498 (Electronic) Linking ISSN: 26322498 NLM ISO Abbreviation: Neurooncol Adv Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : Oxford University Press, [2019]-
مستخلص: Background: Gliomas are the most common type of primary brain tumor and one of many cancers where males are diagnosed with greater frequency than females. However, little is known about the sex-based molecular differences in glioblastomas (GBMs) or lower grade glioma (non-GBM) subtypes. DNA methylation is an epigenetic mechanism involved in regulating gene transcription. In glioma and other cancers, hypermethylation of specific gene promoters downregulates transcription and may have a profound effect on patient outcome. The purpose of this study was to determine if sex-based methylation differences exist in different glioma subtypes.
Methods: Molecular and clinical data from glioma patients were obtained from The Cancer Genome Atlas and grouped according to tumor grade and molecular subtype ( IDH1/2 mutation and 1p/19q chromosomal deletion). Sex-specific differentially methylated probes (DMPs) were identified in each subtype and further analyzed to determine if they were part of differentially methylated regions (DMRs) or associated with differentially methylated DNA transcription regulatory binding motifs.
Results: Analysis of methylation data in 4 glioma subtypes revealed unique sets of both sex-specific DMPs and DMRs in each subtype. Motif analysis based on DMP position also identified distinct sex-based sets of DNA-binding motifs that varied according to glioma subtype. Downstream targets of 2 of the GBM-specific transcription binding sites, NFAT5 and KLF6 , showed differential gene expression consistent with increased methylation mediating downregulation.
Conclusion: DNA methylation differences between males and females in 4 glioma molecular subtypes suggest an important, sex-specific role for DNA methylation in epigenetic regulation of gliomagenesis.
(© The Author(s) 2020. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology.)
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معلومات مُعتمدة: T32 CA094186 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: DNA methylation; glioblastoma; glioma; sex-specific differences; survival
تواريخ الأحداث: Date Created: 20200710 Latest Revision: 20220415
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7212920
DOI: 10.1093/noajnl/vdaa002
PMID: 32642674
قاعدة البيانات: MEDLINE
الوصف
تدمد:2632-2498
DOI:10.1093/noajnl/vdaa002