دورية أكاديمية
أعرض في EDS

Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection.

التفاصيل البيبلوغرافية
العنوان: Graft IL-33 regulates infiltrating macrophages to protect against chronic rejection.
المؤلفون: Li T; Department of Surgery and.; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Kidney Transplantation and., Zhang Z; Department of Surgery and.; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Organ Transplantation and General Surgery, Second Xiangya Hospital of Central South University, Changsha, China., Bartolacci JG; Department of Surgery and.; McGowan Institute for Regenerative Medicine and., Dwyer GK; Department of Surgery and.; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Liu Q; Department of Surgery and.; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Southern University of Science and Technology, Shenzhen, China., Mathews LR; Department of Surgery and.; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Velayutham M; Department of Surgery and.; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Pittsburgh Heart, Lung, and Blood, Vascular Medicine Institute and.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Roessing AS; Department of Surgery and.; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Lee YC; McGowan Institute for Regenerative Medicine and.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Dai H; Department of Surgery and.; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Kidney Transplantation and., Shiva S; Pittsburgh Heart, Lung, and Blood, Vascular Medicine Institute and.; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Oberbarnscheidt MH; Department of Surgery and.; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Dziki JL; Department of Surgery and.; McGowan Institute for Regenerative Medicine and., Mullet SJ; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Health Sciences Metabolomics and Lipidomics Core and.; Clinical Translational Science Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Wendell SG; Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.; Health Sciences Metabolomics and Lipidomics Core and.; Clinical Translational Science Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Wilkinson JD; Department of Pediatrics, Vanderbilt School of Medicine, Nashville, Tennessee, USA., Webber SA; Department of Pediatrics, Vanderbilt School of Medicine, Nashville, Tennessee, USA., Wood-Trageser M; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; Department of Pathology and., Watkins SC; Department of Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA., Demetris AJ; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; McGowan Institute for Regenerative Medicine and.; Department of Pathology and., Hussey GS; Department of Surgery and.; McGowan Institute for Regenerative Medicine and., Badylak SF; Department of Surgery and.; McGowan Institute for Regenerative Medicine and.; Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Turnquist HR; Department of Surgery and.; Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.; McGowan Institute for Regenerative Medicine and.; Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
المصدر: The Journal of clinical investigation [J Clin Invest] 2020 Oct 01; Vol. 130 (10), pp. 5397-5412.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Print Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE
أسماء مطبوعة: Publication: 1999- : Ann Arbor, MI : American Society for Clinical Investigation
Original Publication: New Haven [etc.] American Society for Clinical Investigation.
مواضيع طبية MeSH: Graft Rejection/*immunology , Graft Rejection/*prevention & control , Heart Transplantation/*adverse effects , Interleukin-33/*immunology , Macrophages/*immunology, Alarmins/immunology ; Allografts ; Animals ; Child ; Disease Models, Animal ; Graft Rejection/etiology ; Graft Survival/immunology ; Humans ; Interleukin-33/administration & dosage ; Interleukin-33/deficiency ; Interleukin-33/genetics ; Macrophage Activation/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Mutant Strains ; Myocardium/immunology ; Myocardium/pathology ; Up-Regulation
مستخلص: Alarmins, sequestered self-molecules containing damage-associated molecular patterns, are released during tissue injury to drive innate immune cell proinflammatory responses. Whether endogenous negative regulators controlling early immune responses are also released at the site of injury is poorly understood. Herein, we establish that the stromal cell-derived alarmin interleukin 33 (IL-33) is a local factor that directly restricts the proinflammatory capacity of graft-infiltrating macrophages early after transplantation. By assessing heart transplant recipient samples and using a mouse heart transplant model, we establish that IL-33 is upregulated in allografts to limit chronic rejection. Mouse cardiac transplants lacking IL-33 displayed dramatically accelerated vascular occlusion and subsequent fibrosis, which was not due to altered systemic immune responses. Instead, a lack of graft IL-33 caused local augmentation of proinflammatory iNOS+ macrophages that accelerated graft loss. IL-33 facilitated a metabolic program in macrophages associated with reparative and regulatory functions, and local delivery of IL-33 prevented the chronic rejection of IL-33-deficient cardiac transplants. Therefore, IL-33 represents what we believe is a novel regulatory alarmin in transplantation that limits chronic rejection by restraining the local activation of proinflammatory macrophages. The local delivery of IL-33 in extracellular matrix-based materials may be a promising biologic for chronic rejection prophylaxis.
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معلومات مُعتمدة: T32 CA082084 United States CA NCI NIH HHS; S10 OD011925 United States OD NIH HHS; R01 HL122489 United States HL NHLBI NIH HHS; S10 OD023402 United States OD NIH HHS; R01 AI145881 United States AI NIAID NIH HHS; U01 AI104336 United States AI NIAID NIH HHS; R56 AI139327 United States AI NIAID NIH HHS; R01 AR073527 United States AR NIAMS NIH HHS; F30 AI147437 United States AI NIAID NIH HHS; R21 AI121981 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Immunology; Immunotherapy; Macrophages; Organ transplantation; Transplantation
المشرفين على المادة: 0 (Alarmins)
0 (IL33 protein, human)
0 (Il33 protein, mouse)
0 (Interleukin-33)
تواريخ الأحداث: Date Created: 20200710 Date Completed: 20210216 Latest Revision: 20240214
رمز التحديث: 20240214
مُعرف محوري في PubMed: PMC7524467
DOI: 10.1172/JCI133008
PMID: 32644975
قاعدة البيانات: MEDLINE
الوصف
تدمد:1558-8238
DOI:10.1172/JCI133008