دورية أكاديمية
أعرض في EDS

Rectal gonorrhoea and chlamydia among men who have sex with men in coastal Kenya.

التفاصيل البيبلوغرافية
العنوان: Rectal gonorrhoea and chlamydia among men who have sex with men in coastal Kenya.
المؤلفون: Ngetsa CJ; Department of Bioscience, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Heymann MW; Department of Medicine, Barts and The London NHS Trust, London, E11BB, UK., Thiong'o A; Department of Bioscience, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Wahome E; Department of Bioscience, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Mwambi J; Department of Bioscience, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Karani C; Department of Bioscience, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Menza NC; Department of Medical Laboratory Sciences, Kenyatta University, Nairobi, Kenya., Mwashigadi G; Department of Bioscience, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Muturi MW; Department of Medical Laboratory Sciences, Kenyatta University, Nairobi, Kenya., Graham SM; Department of Medicine, University of Washington, Seattle, WA, USA.; Department of Global Health, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Mugo PM; Department of Bioscience, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya., Sanders EJ; Department of Bioscience, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.; Nuffield Department of Medicine, University of Oxford, Headington, UK.
المصدر: Wellcome open research [Wellcome Open Res] 2020 Jun 04; Vol. 4, pp. 79. Date of Electronic Publication: 2020 Jun 04 (Print Publication: 2019).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wellcome Trust Country of Publication: England NLM ID: 101696457 Publication Model: eCollection Cited Medium: Print ISSN: 2398-502X (Print) Linking ISSN: 2398502X NLM ISO Abbreviation: Wellcome Open Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Wellcome Trust, [2016]-
مستخلص: Background: Men who have sex with men (MSM) have a higher prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) infections compared to the rest of the population, often remaining undiagnosed. In Kenya, prevalence of rectal CT and NG infection and NG antimicrobial sensitivity are poorly described. Methods: MSM who reported receptive anal intercourse (RAI) were recruited from an ongoing human immunodeficiency virus acquisition and treatment study in coastal Kenya in 2016-2017. Rectal swabs were collected at two time points 6 months apart to estimate prevalence and incidence of CT/NG infection using a molecular point-of-care assay. Participants positive for CT or NG were treated according to national guidelines. NG culture and antimicrobial susceptibility testing was performed. Participant and risk behaviour characteristics were collected and association with baseline CT/NG prevalence assessed by multivariable regression analysis. Results: Prevalence of CT/NG in 104 MSM was 21.2% (CT 13.5%, NG 9.6%, dual infection 1.9%) at baseline and 25.9% in 81 MSM at follow-up (CT 14.8%, NG 14.8%, dual infection 3.7%). CT/NG incidence was estimated at 53.0 (95% CI, 34.5-81.3) per 100 person-years. Most CT/NG positive participants were asymptomatic: 95.5% at baseline and 100% at follow-up. CT/NG infection was associated with being paid for sex [adjusted odds ratio (aOR)=6.2, 95% CI (1.7-22.9)] and being in formal employment [aOR=7.5, 95% CI (1.1-49.2)]. Six NG isolates were obtained at follow-up; all were susceptible to ceftriaxone and cefixime and all were resistant to penicillin, tetracycline and ciprofloxacin. Conclusions: There is a high prevalence and incidence of asymptomatic rectal CT and NG in MSM reporting RAI in coastal Kenya. MSM who were paid for sex or had formal employment were more likely to be infected with CT/NG suggesting increased risk behaviour during transactional sex. Antimicrobial susceptibility results suggest that current antibiotic choices in Kenya are appropriate for NG treatment.
Competing Interests: No competing interests were disclosed.
(Copyright: © 2020 Ngetsa CJ et al.)
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معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust; P30 AI027757 United States AI NIAID NIH HHS; R01 AI124968 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Antimicrobial Susceptibility; Azithromycin; Cefixime; Chlamydia; Gonorrhoea; Kenya; Men Who Have Sex With Men
سلسلة جزيئية: figshare 10.6084/m9.figshare.7735001.v1
تواريخ الأحداث: Date Created: 20200714 Latest Revision: 20240216
رمز التحديث: 20240216
مُعرف محوري في PubMed: PMC7323594
DOI: 10.12688/wellcomeopenres.15217.4
PMID: 32647750.4. Version: 4. Publisher Version ID: 4. Version Date: 2020/06/04
قاعدة البيانات: MEDLINE
الوصف
تدمد:2398-502X
DOI:10.12688/wellcomeopenres.15217.4