Can patients with papillary thyroid carcinoma and low postoperative thyroglobulin in the presence of clinically apparent lymph node metastases (cN1) be spared from radioiodine?

التفاصيل البيبلوغرافية
العنوان:	Can patients with papillary thyroid carcinoma and low postoperative thyroglobulin in the presence of clinically apparent lymph node metastases (cN1) be spared from radioiodine?
المؤلفون:	Rosario PW; Santa Casa de Belo Horizonte, Minas Gerais, Brazil. pedrowsrosario@gmail.com., Mourão GF; Santa Casa de Belo Horizonte, Minas Gerais, Brazil., Calsolari MR; Santa Casa de Belo Horizonte, Minas Gerais, Brazil.
المصدر:	Endocrine [Endocrine] 2020 Dec; Vol. 70 (3), pp. 552-557. Date of Electronic Publication: 2020 Jul 11.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't
اللغة:	English
بيانات الدورية:	Publisher: Humana Press Country of Publication: United States NLM ID: 9434444 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0100 (Electronic) Linking ISSN: 1355008X NLM ISO Abbreviation: Endocrine Subsets: MEDLINE
أسماء مطبوعة:	Publication: Feb. 1996- : Totowa, NJ : Humana Press Original Publication: Houndsmills, Basingstoke, Hants, UK : Macmillan Press, c1994-
مواضيع طبية MeSH:	Carcinoma/surgery , Carcinoma, Papillary/radiotherapy , Thyroid Neoplasms/radiotherapy , Thyroid Neoplasms/surgery, Humans ; Iodine Radioisotopes/therapeutic use ; Lymphatic Metastasis ; Neoplasm Recurrence, Local ; Prospective Studies ; Thyroglobulin ; Thyroid Cancer, Papillary/surgery ; Thyroidectomy
مستخلص:	Background: The study evaluated the recurrence rate in patients with papillary thyroid carcinoma (PTC) and clinically apparent lymph node metastases (LNM) (cN1) who had low thyroglobulin (Tg) after total thyroidectomy and who were not submitted to adjuvant therapy with ¹³¹ I. Methods: This was a prospective study. It included 82 cN1 patients (≤3 LNM ≤1.5 cm without macroscopic extracapsular extension) with tumors ≤4 cm without macroscopic extrathyroid invasion (T1-2) and who after thyroidectomy had unstimulated Tg (u-Tg) < 0.3 ng/ml, negative antithyroglobulin antibodies (TgAb), and neck ultrasonography (US) showing no anomalies. The patients were not submitted to therapy with ¹³¹ I. Results: The time of follow-up ranged from 24 to 156 months (median 84 months). Seventy-nine patients (96.3%) continued to have u-Tg < 0.3 ng/ml and negative US. Three patients (3.6%) exhibited an increase in Tg and structural recurrence was detected in two. After treatment, these patients achieved u-Tg < 1 ng/ml and the imaging methods revealed no apparent tumor. Conclusions: The results suggest that even cN1 patients, given the absence of extensive LNM or other adverse findings, who have low Tg and neck US showing no anomalies after thyroidectomy do not require radioiodine.
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فهرسة مساهمة:	Keywords: Lymph Node Metastases; Papillary Thyroid Carcinoma; Postoperative Nonstimulated Thyroglobulin; Radioiodine
المشرفين على المادة:	0 (Iodine Radioisotopes) 9010-34-8 (Thyroglobulin)
تواريخ الأحداث:	Date Created: 20200713 Date Completed: 20210621 Latest Revision: 20210621
رمز التحديث:	20240628
DOI:	10.1007/s12020-020-02414-1
PMID:	32653994
قاعدة البيانات:	MEDLINE

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تدمد:	1559-0100
DOI:	10.1007/s12020-020-02414-1