دورية أكاديمية
Should we wait 3 months for a repeat aspiration in non-diagnostic/indeterminate thyroid nodules? A cancer centre experience.
العنوان: | Should we wait 3 months for a repeat aspiration in non-diagnostic/indeterminate thyroid nodules? A cancer centre experience. |
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المؤلفون: | Valerio E; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Pastorello RG; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Calsavara V; Department of Epidemiology and Statistics, A.C. Camargo Cancer Center, São Paulo, Brazil., Porfírio MM; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Engelman GG; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Francisco Dalcin J; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Bovolim G; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Domingos T; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., De Brot L; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Saieg M; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil.; Department of Pathology, Santa Casa Medical School, São Paulo, Brazil.; Department of Pathology, Fleury Laboratories, São Paulo, Brazil. |
المصدر: | Cytopathology : official journal of the British Society for Clinical Cytology [Cytopathology] 2020 Nov; Vol. 31 (6), pp. 525-532. Date of Electronic Publication: 2020 Aug 09. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9010345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2303 (Electronic) Linking ISSN: 09565507 NLM ISO Abbreviation: Cytopathology Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Oxford : Blackwell Scientific Publications, c1990- |
مواضيع طبية MeSH: | Biopsy, Fine-Needle*, Thyroid Gland/*diagnostic imaging , Thyroid Neoplasms/*diagnosis , Thyroid Nodule/*diagnosis, Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Regression Analysis ; Thyroid Gland/pathology ; Thyroid Neoplasms/pathology ; Thyroid Nodule/pathology |
مستخلص: | Introduction: The Bethesda System recommends repeat fine needle aspiration (rFNA) as a management option for nodules classified under the non-diagnostic (ND) and atypia of undetermined significance (AUS/FLUS) categories. We evaluated the impact of an rFNA in diagnostic resolution and the role of early (≤3 months) vs delayed (more than 3 months) rFNA of nodules initially diagnosed as ND and AUS/FLUS. Methods: We retrospectively collected all thyroid FNA performed in a 4-year period with repeat aspiration. For cases initially signed out as ND or AUS/FLUS, diagnostic resolution was defined as a change to a Bethesda System category other than these two on rFNA. Comparison and regression models were fitted to identify the impact of time of rFNA on diagnostic resolution. Results: In total, 184 cases were initially assigned as ND and 143 as AUS/FLUS, with overall diagnostic resolution rates for the reassessment of these nodules calculated at 70.1% and 62.9%, respectively. For ND cases, time of rFNA was not significantly associated with diagnostic resolution (P > .05). For AUS/FLUS nodules, however, repeat aspiration performed in more than 3 months after the initial diagnosis was 2.5 times more likely to achieve a resolution in diagnosis than early rFNA (P = .024). Conclusions: Repeat aspiration of ND and AUS/FLUS nodules helped define diagnosis for the majority of cases, being highly effective in determining correct patient management. For AUS/FLUS nodules, repeat aspiration performed more than 3 months after the initial diagnosis was associated with a higher diagnostic resolution. (© 2020 John Wiley & Sons Ltd.) |
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فهرسة مساهمة: | Keywords: cytology; fine needle aspiration; thyroid gland; thyroid nodule |
تواريخ الأحداث: | Date Created: 20200714 Date Completed: 20210812 Latest Revision: 20210812 |
رمز التحديث: | 20240628 |
DOI: | 10.1111/cyt.12887 |
PMID: | 32656878 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1365-2303 |
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DOI: | 10.1111/cyt.12887 |