دورية أكاديمية
أعرض في EDS

Should we wait 3 months for a repeat aspiration in non-diagnostic/indeterminate thyroid nodules? A cancer centre experience.

التفاصيل البيبلوغرافية
العنوان: Should we wait 3 months for a repeat aspiration in non-diagnostic/indeterminate thyroid nodules? A cancer centre experience.
المؤلفون: Valerio E; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Pastorello RG; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Calsavara V; Department of Epidemiology and Statistics, A.C. Camargo Cancer Center, São Paulo, Brazil., Porfírio MM; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Engelman GG; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Francisco Dalcin J; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Bovolim G; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Domingos T; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., De Brot L; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil., Saieg M; Department of Pathology, A.C. Camargo Cancer Center, São Paulo, Brazil.; Department of Pathology, Santa Casa Medical School, São Paulo, Brazil.; Department of Pathology, Fleury Laboratories, São Paulo, Brazil.
المصدر: Cytopathology : official journal of the British Society for Clinical Cytology [Cytopathology] 2020 Nov; Vol. 31 (6), pp. 525-532. Date of Electronic Publication: 2020 Aug 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9010345 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2303 (Electronic) Linking ISSN: 09565507 NLM ISO Abbreviation: Cytopathology Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford : Blackwell Scientific Publications, c1990-
مواضيع طبية MeSH: Biopsy, Fine-Needle*, Thyroid Gland/*diagnostic imaging , Thyroid Neoplasms/*diagnosis , Thyroid Nodule/*diagnosis, Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Regression Analysis ; Thyroid Gland/pathology ; Thyroid Neoplasms/pathology ; Thyroid Nodule/pathology
مستخلص: Introduction: The Bethesda System recommends repeat fine needle aspiration (rFNA) as a management option for nodules classified under the non-diagnostic (ND) and atypia of undetermined significance (AUS/FLUS) categories. We evaluated the impact of an rFNA in diagnostic resolution and the role of early (≤3 months) vs delayed (more than 3 months) rFNA of nodules initially diagnosed as ND and AUS/FLUS.
Methods: We retrospectively collected all thyroid FNA performed in a 4-year period with repeat aspiration. For cases initially signed out as ND or AUS/FLUS, diagnostic resolution was defined as a change to a Bethesda System category other than these two on rFNA. Comparison and regression models were fitted to identify the impact of time of rFNA on diagnostic resolution.
Results: In total, 184 cases were initially assigned as ND and 143 as AUS/FLUS, with overall diagnostic resolution rates for the reassessment of these nodules calculated at 70.1% and 62.9%, respectively. For ND cases, time of rFNA was not significantly associated with diagnostic resolution (P > .05). For AUS/FLUS nodules, however, repeat aspiration performed in more than 3 months after the initial diagnosis was 2.5 times more likely to achieve a resolution in diagnosis than early rFNA (P = .024).
Conclusions: Repeat aspiration of ND and AUS/FLUS nodules helped define diagnosis for the majority of cases, being highly effective in determining correct patient management. For AUS/FLUS nodules, repeat aspiration performed more than 3 months after the initial diagnosis was associated with a higher diagnostic resolution.
(© 2020 John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: cytology; fine needle aspiration; thyroid gland; thyroid nodule
تواريخ الأحداث: Date Created: 20200714 Date Completed: 20210812 Latest Revision: 20210812
رمز التحديث: 20240628
DOI: 10.1111/cyt.12887
PMID: 32656878
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2303
DOI:10.1111/cyt.12887