دورية أكاديمية
أعرض في EDS

The link between dynamic hyperinflation, autonomic dysfunction and exercise testing parameters with masked heart failure in patients with non-severe obstructive pulmonary disease.

التفاصيل البيبلوغرافية
العنوان: The link between dynamic hyperinflation, autonomic dysfunction and exercise testing parameters with masked heart failure in patients with non-severe obstructive pulmonary disease.
المؤلفون: Cherneva RV; University Hospital for Respiratory Diseases 'St. Sophia'', Han Presian 17, Sofia, Bulgaria., Denchev SV; Medical Institute of the Ministry of Internal Affairs, Gen Skobelev 79, Sofia, Bulgaria., Cherneva ZV; Medical Institute of the Ministry of Internal Affairs, Gen Skobelev 79, Sofia, Bulgaria.
المصدر: Journal of basic and clinical physiology and pharmacology [J Basic Clin Physiol Pharmacol] 2020 Jul 13; Vol. 32 (3), pp. 179-188. Date of Electronic Publication: 2020 Jul 13.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 9101750 Publication Model: Electronic Cited Medium: Internet ISSN: 2191-0286 (Electronic) Linking ISSN: 07926855 NLM ISO Abbreviation: J Basic Clin Physiol Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: Jun. 2011- : Berlin : Walter de Gruyter
Original Publication: London, England : Freund Pub. House, c1990-
مواضيع طبية MeSH: Autonomic Nervous System Diseases/*epidemiology , Heart Failure/*epidemiology , Pulmonary Disease, Chronic Obstructive/*epidemiology, Aged ; Autonomic Nervous System ; Autonomic Nervous System Diseases/physiopathology ; Exercise Test ; Female ; Heart Failure/physiopathology ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; Oxygen Consumption/physiology ; Prospective Studies ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Respiratory Function Tests ; Stroke Volume
مستخلص: Objectives: Autonomic dysfunction (AD) and dynamic hyperinflation (DH) have been implicated as pathophysiological mechanisms of heart failure with preserved ejection fraction (HFpEF) in chronic obstructive pulmonary disease ( COPD) patients. Their association, however, remains elusive: The aims of the study were: (1) to determine the prevalence of AD and DH in non-severe COPD patients, with exertional dyspnea, without clinically overt cardio-vascular (CV) comorbidities; (2) to analyze the correlation and clinical significance between DH, AD, and maksed HFpEF.
Methods: We applied CPET in 68 subjects. Echocardiography was performed before CPET and 1-2 min after peak exercise. IC manoeuvres were applied. Patients were divided into two groups: patients with and without masked HFpEF. Wilkoff method calculated the meatabolic - chronotropic relationship (MCR). Chronotropic incompetence (CI) and abnormal HR recovery (HRR) were determined.
Results: The prevalence of CI was 77 vs. 52% in patients with/without masked HFpEF; of abnormal HRR - 98 vs. 62% respectively; of DH - 53 vs. 29%. ICdyn was associated with AD. Univariate regression showed association between masked HFpEF, ICdyn, HRR, oxygenuptake ('VO 2 ), 'VO 2 at anaerobic threshold, oxygen (O 2 ) pulse and 'VE/'VCO 2 slope. None of these parameters is an independent predictor for masked HFpEF.
Conclusions: DH, AD, and masked HFpEF are prevalent in non-severe COPD patients, who complain of exertional dyspnea and are free of clinically overt CV comorbidities. DH is independently associated with AD. Neither AD, nor DH and CPET are independent predictors for masked HFpEF.
(© 2020 Walter de Gruyter GmbH, Berlin/Boston.)
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فهرسة مساهمة: Keywords: autonomic dysfunction; dynamic hyperinflation; heart failure with preserved ejection fraction; non-severe chronic obstructive pulmonary disease
تواريخ الأحداث: Date Created: 20200714 Date Completed: 20211115 Latest Revision: 20211115
رمز التحديث: 20221213
DOI: 10.1515/jbcpp-2019-0311
PMID: 32658862
قاعدة البيانات: MEDLINE
الوصف
تدمد:2191-0286
DOI:10.1515/jbcpp-2019-0311