دورية أكاديمية
أعرض في EDS

Comparative testis structure and function in three representative mice strains.

التفاصيل البيبلوغرافية
العنوان: Comparative testis structure and function in three representative mice strains.
المؤلفون: de Oliveira CFA; Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Lara NLEM; Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., Cardoso BRL; Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil., de França LR; Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. lrfranca@icb.ufmg.br., de Avelar GF; Laboratory of Cellular Biology, Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil. gleideav@yahoo.com.br.
المصدر: Cell and tissue research [Cell Tissue Res] 2020 Nov; Vol. 382 (2), pp. 391-404. Date of Electronic Publication: 2020 Jul 14.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0878 (Electronic) Linking ISSN: 0302766X NLM ISO Abbreviation: Cell Tissue Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: Testis/*anatomy & histology , Testis/*physiology, Animals ; Male ; Mice
مستخلص: Mice are widely used as experimental models due to several positive characteristics and in particular their suitability for studies involving molecular biology and transgenesis. Despite the large number of mice strains currently available, the literature regarding their basic reproductive biology is still relatively scarce. Herein, we comparatively evaluated several important and correlated parameters related to testis structure and function in sexually mature male mice of inbred (C57BL/6, n = 19; BALB/c, n = 17) and outbred (Swiss, n = 17) strains, frequently utilized in research. Swiss mice presented significant variation for many parameters evaluated, including higher sperm production, mainly when compared to the C57BL/6 strain. However, some key parameters such as the duration of spermatogenesis, the Sertoli cell number per testis, and the spermatogenic efficiency were similar among the different strains. Although presenting significantly higher Leydig cell (LC) proportion and numbers per testis gram and per testis, the anogenital index was smaller in Swiss mice. Estradiol levels were lower in C57BL/6, whereas testosterone levels and 3β-HSD expression were similar among strains. Regarding the LC/macrophages relationship, in comparison to the literature, we reported a much higher contribution of macrophages to the mouse intertubule. Thus, we estimated that there are around 1.6 macrophages per LC in BALB/c mice and this intriguing finding could be relevant to testis function in overall and spermatogonial biology in particular. Taken together, our results highlight the importance of knowing more accurately the testis structure and function in the different mice strains available for research, particularly when a specific testis parameter is being investigated.
التعليقات: Erratum in: Cell Tissue Res. 2021 Feb;383(2):907-910. (PMID: 33386996)
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معلومات مُعتمدة: NA Conselho Nacional de Desenvolvimento Científico e Tecnológico; NA Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Scholarship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: Leydig cell; Macrophages; Mice strains; Sertoli cell; Sperm production
تواريخ الأحداث: Date Created: 20200716 Date Completed: 20210714 Latest Revision: 20210716
رمز التحديث: 20221213
DOI: 10.1007/s00441-020-03239-0
PMID: 32666138
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-0878
DOI:10.1007/s00441-020-03239-0