Therapeutic potential of alkaloids in autoimmune diseases: Promising candidates for clinical trials.

التفاصيل البيبلوغرافية
العنوان:	Therapeutic potential of alkaloids in autoimmune diseases: Promising candidates for clinical trials.
المؤلفون:	Khan H; Abdul Wali khan university Mardan, Abdul Wali khan university Mardan, Department of Pharmacy, Abdul Wali Khan university Mardan, Pakistan, Mardan, Pakistan, 23200, Pakistan., Ullah H; Department of Pharmacy, University of Naples Federico II, Naples, Italy., Khattak S; Abdul Wali khan university Mardan, Abdul Wali khan university Mardan, Department of Pharmacy, Abdul Wali Khan university Mardan, Pakistan, Mardan, Pakistan, 23200, Pakistan., Aschner M; Department of Molecular Pharmacology, Albert Einstein College of Medicine, New York, New York, USA., Aguilar CN; School of Chemistry, Universidad Autónoma de Coahuila Saltillo, Saltillo, Mexico., Halimi SMA; Department of Pharmacy, University of Peshawar, Peshawar, Pakistan., Cauli O; Department of Nursing, University of Valencia, Valencia, Spain., Shah SMM; Department of Pharmacy, University of Swabi Pakistan, Swabi, Pakistan.
المصدر:	Phytotherapy research : PTR [Phytother Res] 2021 Jan; Vol. 35 (1), pp. 50-62. Date of Electronic Publication: 2020 Jul 15.
نوع المنشور:	Journal Article; Review
اللغة:	English
بيانات الدورية:	Publisher: Wiley Country of Publication: England NLM ID: 8904486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1573 (Electronic) Linking ISSN: 0951418X NLM ISO Abbreviation: Phytother Res Subsets: MEDLINE
أسماء مطبوعة:	Publication: : Chichester : Wiley Original Publication: London : Heyden & Son, c1987-
مواضيع طبية MeSH:	Alkaloids/therapeutic use , Autoimmune Diseases/drug therapy, Alkaloids/pharmacology ; Animals ; Humans
مستخلص:	Clinical investigations have characterized numerous disorders like autoimmune diseases, affecting the population at a rate of approximately 8-10%. These disorders are characterized by T-cell and auto-antibodies responses to self-molecules by immune system reactivity. Several therapeutic options have been adopted in clinics to combat such diseases, however, most of them are recurring. Thus, the discovery of new effective agents for the treatment of autoimmune diseases is paramount. In this context, natural products might be a useful alternative to the current therapies. Plant alkaloids with their substantial therapeutic history can be particularly interesting candidates for the alleviation of autoimmune ailments. This review encompasses various alkaloids with significant effects against autoimmune diseases in preclinical trials. These results suggest further clinical assessment with respect to autoimmune illnesses. Furthermore, the application of modern technologies such as nanoformulation could be also helpful in the design of more effective therapies and thus further studies are needed to decipher their therapeutic efficacy as well as potential limitations. (© 2020 John Wiley & Sons, Ltd.)
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معلومات مُعتمدة:	R01ES020852 United States ES NIEHS NIH HHS; R01ES10563 United States ES NIEHS NIH HHS; R01ES07331 United States ES NIEHS NIH HHS; R01ES020852 United States ES NIEHS NIH HHS; R01ES10563 United States ES NIEHS NIH HHS; R01ES07331 United States ES NIEHS NIH HHS
فهرسة مساهمة:	Keywords: alkaloids; autoimmune diseases; preclinical trials, clinical perspective; therapeutic limitations
المشرفين على المادة:	0 (Alkaloids)
تواريخ الأحداث:	Date Created: 20200716 Date Completed: 20210226 Latest Revision: 20210226
رمز التحديث:	20221213
DOI:	10.1002/ptr.6763
PMID:	32667693
قاعدة البيانات:	MEDLINE

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تدمد:	1099-1573
DOI:	10.1002/ptr.6763