دورية أكاديمية
Investigation of cytotoxicity potential of different extracts of Ziziphus mauritiana (Lam) leaf Allium cepa model.
| العنوان: | Investigation of cytotoxicity potential of different extracts of Ziziphus mauritiana (Lam) leaf Allium cepa model. |
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| المؤلفون: | Owolarafe TA; Department of Biochemistry and Forensic Science, Nigeria Police Academy Wudil, Kano, Nigeria., Salawu K; Department of Biochemistry and Forensic Science, Nigeria Police Academy Wudil, Kano, Nigeria., Ihegboro GO; Department of Biochemistry and Forensic Science, Nigeria Police Academy Wudil, Kano, Nigeria., Ononamadu CJ; Department of Biochemistry and Forensic Science, Nigeria Police Academy Wudil, Kano, Nigeria., Alhassan AJ; Department of Biochemistry, Bayero University Kano, Nigeria., Wudil AM; Department of Biochemistry, Bayero University Kano, Nigeria. |
| المصدر: | Toxicology reports [Toxicol Rep] 2020 Jun 30; Vol. 7, pp. 816-821. Date of Electronic Publication: 2020 Jun 30 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ireland Ltd Country of Publication: Ireland NLM ID: 101630272 Publication Model: eCollection Cited Medium: Internet ISSN: 2214-7500 (Electronic) Linking ISSN: 22147500 NLM ISO Abbreviation: Toxicol Rep Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Ireland] : Elsevier Ireland Ltd., [2014]- |
| مستخلص: | Previous studies showed that Ziziphus mauritiana is ethnomedicinally beneficial against various diseases, however the cytotoxic and genotoxic effects of this plant have not been well investigated. Therefore this study was undertaken to investigate cytotoxic and genotoxic effects of four different solvents extracts of Ziziphus mauritiana (Lam) leaf at different concentrations (20, 40, 60, 80, and 100 mg/L) using Allium cepa model . The cytotoxicity and genotoxicity parameters evaluated were mitotic index, root tip growth length and chromosomal aberration respectively. The result revealed a decrease in mitotic index percentage (%MI) and a dose dependent decrease in root tip length with increase in extracts concentration for all the extracts studied - with the ethanol extract showing the most significant effect in mitotic index. Furthermore, the effective concentrations (EC Competing Interests: The authors declared that there is no competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2020 Published by Elsevier B.V.) |
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| فهرسة مساهمة: | Keywords: Allium cepa; Chromosomal aberration; Cytotocixicity; Genotoxicity; Ziziphus mauritiana |
| تواريخ الأحداث: | Date Created: 20200717 Latest Revision: 20200928 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7341450 |
| DOI: | 10.1016/j.toxrep.2020.06.010 |
| PMID: | 32670799 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2214-7500 |
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| DOI: | 10.1016/j.toxrep.2020.06.010 |