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Ayahuasca blocks the reinstatement of methylphenidate-induced conditioned place preference in mice: behavioral and brain Fos expression evaluations.

التفاصيل البيبلوغرافية
العنوان: Ayahuasca blocks the reinstatement of methylphenidate-induced conditioned place preference in mice: behavioral and brain Fos expression evaluations.
المؤلفون: Reis HS; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Rodrigues IRS; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Anjos-Santos A; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Libarino-Santos M; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Serra YA; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Cata-Preta EG; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Oliveira-Campos D; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Kisaki ND; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Barros-Santos T; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Yokoyama TS; Department of Pharmacology, Universidade Federal de São Paulo, Leal Prado Building, Botucatu 862 Street, 04024-002, Vila Clementino, São Paulo, SP, Brazil., Cruz FC; Department of Pharmacology, Universidade Federal de São Paulo, Leal Prado Building, Botucatu 862 Street, 04024-002, Vila Clementino, São Paulo, SP, Brazil., Oliveira-Lima AJ; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Barbosa PCR; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil., Berro LF; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil. lberro@umc.edu.; Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, 2500 N State St, Jackson, MS, 39216, USA. lberro@umc.edu., Marinho EAV; Department of Health Sciences, Universidade Estadual de Santa Cruz, Rod. Ilhéus/Itabuna, Km 16, Ilhéus, BA, 45662-0, Brazil. edumarinho@hotmail.com.
المصدر: Psychopharmacology [Psychopharmacology (Berl)] 2020 Nov; Vol. 237 (11), pp. 3269-3281. Date of Electronic Publication: 2020 Jul 16.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 7608025 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2072 (Electronic) Linking ISSN: 00333158 NLM ISO Abbreviation: Psychopharmacology (Berl) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Berlin, New York, Springer-Verlag.
مواضيع طبية MeSH: Banisteriopsis*, Brain/*drug effects , Brain/*metabolism , Conditioning, Classical/*drug effects , Methylphenidate/*administration & dosage , Proto-Oncogene Proteins c-fos/*biosynthesis, Administration, Oral ; Animals ; Central Nervous System Stimulants/administration & dosage ; Conditioning, Classical/physiology ; Drug-Seeking Behavior/drug effects ; Drug-Seeking Behavior/physiology ; Gene Expression ; Hallucinogens/administration & dosage ; Male ; Mice ; Proto-Oncogene Proteins c-fos/genetics
مستخلص: Rationale: Accumulating evidence suggests that ayahuasca, a hallucinogenic beverage used in traditional Amazonian communities for ritualistic and curative purposes, has been associated with reduced rates of substance use disorders. However, the brain mechanisms underlying the therapeutic effects of ayahuasca have not yet been fully elucidated.
Objectives: The aim of the present study was to investigate the effects of treatment with ayahuasca on the rewarding properties of the psychostimulant methylphenidate.
Methods: The rewarding properties of ayahuasca (100 mg/kg, orally) and methylphenidate (10 mg/kg, i.p.) were investigated using the conditioned place preference (CPP) model. Furthermore, we evaluated the effects of repeated treatment with ayahuasca on the reinstatement of methylphenidate-induced CPP. Fos expression was evaluated in different limbic structures (cingulate cortex-area 1, prelimbic cortex, infralimbic cortex, orbitofrontal cortex-lateral orbital area, nucleus accumbens core and shell, ventral tegmental area, dorsal striatum, and basolateral amygdala) upon each experimental phase.
Results: Both ayahuasca and methylphenidate induced CPP in mice. However, ayahuasca had limited effects on Fos expression, while methylphenidate altered Fos expression in several brain regions associated with the behavioral effects of drugs of abuse. Treatment with ayahuasca after conditioning with methylphenidate blocked the reinstatement of methylphenidate-induced CPP. Those behavioral effects were accompanied by changes in Fos expression patterns, with ayahuasca generally blocking the changes in Fos expression induced by conditioning with methylphenidate and/or reexposure to methylphenidate.
Conclusions: Our findings suggest that ayahuasca restored normal brain function in areas associated with the long-term expression of drug wanting/seeking in animals conditioned to methylphenidate.
معلومات مُعتمدة: N/A Fundação de Amparo à Pesquisa do Estado da Bahia; N/A Fundação de Amparo à Pesquisa do Estado de São Paulo; N/A Conselho Nacional de Desenvolvimento Científico e Tecnológico; N/A Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
فهرسة مساهمة: Keywords: Ayahuasca; Conditioned place preference; Fos; Methylphenidate; Mice
المشرفين على المادة: 0 (Central Nervous System Stimulants)
0 (Hallucinogens)
0 (Proto-Oncogene Proteins c-fos)
207ZZ9QZ49 (Methylphenidate)
تواريخ الأحداث: Date Created: 20200718 Date Completed: 20210127 Latest Revision: 20210127
رمز التحديث: 20221213
DOI: 10.1007/s00213-020-05609-6
PMID: 32676773
قاعدة البيانات: MEDLINE
الوصف
تدمد:1432-2072
DOI:10.1007/s00213-020-05609-6