دورية أكاديمية
COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation.
| العنوان: | COVID-19, Mast Cells, Cytokine Storm, Psychological Stress, and Neuroinflammation. |
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| المؤلفون: | Kempuraj D; Department of Neurology, and the Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, U.S. Department of Veterans Affairs, Columbia, MO, USA., Selvakumar GP; Department of Neurology, and the Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, U.S. Department of Veterans Affairs, Columbia, MO, USA., Ahmed ME; Department of Neurology, and the Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, U.S. Department of Veterans Affairs, Columbia, MO, USA., Raikwar SP; Department of Neurology, and the Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, U.S. Department of Veterans Affairs, Columbia, MO, USA., Thangavel R; Department of Neurology, and the Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, U.S. Department of Veterans Affairs, Columbia, MO, USA., Khan A; Department of Neurology, and the Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO, USA., Zaheer SA; Department of Neurology, and the Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO, USA., Iyer SS; Department of Neurology, and the Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, U.S. Department of Veterans Affairs, Columbia, MO, USA., Burton C; Phelps Health, Rolla, MO, USA., James D; Phelps Health, Rolla, MO, USA., Zaheer A; Department of Neurology, and the Center for Translational Neuroscience, School of Medicine, University of Missouri, Columbia, MO, USA.; Harry S. Truman Memorial Veterans Hospital, U.S. Department of Veterans Affairs, Columbia, MO, USA. |
| المصدر: | The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [Neuroscientist] 2020 Oct-Dec; Vol. 26 (5-6), pp. 402-414. Date of Electronic Publication: 2020 Jul 18. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Publications Country of Publication: United States NLM ID: 9504819 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-4098 (Electronic) Linking ISSN: 10738584 NLM ISO Abbreviation: Neuroscientist Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2001->: Thousand Oaks, CA : Sage Publications Original Publication: Baltimore, MD : Williams & Wilkins, c1995- |
| مواضيع طبية MeSH: | Betacoronavirus/*immunology , Coronavirus Infections/*immunology , Coronavirus Infections/*physiopathology , Cytokines/*immunology , Mast Cells/*immunology , Nervous System Diseases/*immunology , Pneumonia, Viral/*immunology , Pneumonia, Viral/*physiopathology , Stress, Psychological/*physiopathology, COVID-19 ; Coronavirus Infections/complications ; Humans ; Mast Cells/virology ; Nervous System Diseases/complications ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 |
| مستخلص: | Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new pandemic infectious disease that originated in China. COVID-19 is a global public health emergency of international concern. COVID-19 causes mild to severe illness with high morbidity and mortality, especially in preexisting risk groups. Therapeutic options are now limited to COVID-19. The hallmark of COVID-19 pathogenesis is the cytokine storm with elevated levels of interleukin-6 (IL-6), IL-1β, tumor necrosis factor-alpha (TNF-α), chemokine (C-C-motif) ligand 2 (CCL2), and granulocyte-macrophage colony-stimulating factor (GM-CSF). COVID-19 can cause severe pneumonia, and neurological disorders, including stroke, the damage to the neurovascular unit, blood-brain barrier disruption, high intracranial proinflammatory cytokines, and endothelial cell damage in the brain. Mast cells are innate immune cells and also implicated in adaptive immune response, systemic inflammatory diseases, neuroinflammatory diseases, traumatic brain injury and stroke, and stress disorders. SARS-CoV-2 can activate monocytes/macrophages, dendritic cells, T cells, mast cells, neutrophils, and induce cytokine storm in the lung. COVID-19 can activate mast cells, neurons, glial cells, and endothelial cells. SARS-CoV-2 infection can cause psychological stress and neuroinflammation. In conclusion, COVID-19 can induce mast cell activation, psychological stress, cytokine storm, and neuroinflammation. |
| معلومات مُعتمدة: | W911NF-14-2-0034 International US Army Research Laboratory |
| فهرسة مساهمة: | Keywords: COVID-19; angiotensin-converting enzyme 2; cytokine storm; mast cells; neuroinflammation; severe acute respiratory syndrome coronavirus 2; traumatic brain injury |
| المشرفين على المادة: | 0 (Cytokines) |
| تواريخ الأحداث: | Date Created: 20200721 Date Completed: 20201016 Latest Revision: 20201218 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1177/1073858420941476 |
| PMID: | 32684080 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1089-4098 |
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| DOI: | 10.1177/1073858420941476 |