دورية أكاديمية
Association of serum folate and vitamin B12 with pre-neoplastic cervical lesions.
| العنوان: | Association of serum folate and vitamin B12 with pre-neoplastic cervical lesions. |
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| المؤلفون: | Silva NNT; Programa de Pós-Graduação em Ciências Farmacêuticas, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, Minas Gerais, 35400-000, Brazil. Electronic address: nayarants@gmail.com., Silva Santos AC; Programa de Pós-Graduação em Ciências Farmacêuticas, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, Minas Gerais, 35400-000, Brazil., Carneiro CM; Programa de Pós-Graduação em Ciências Biológicas e Biotecnologia, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, Minas Gerais, 35400-000, Brazil., Lima AA; Programa de Pós-Graduação em Ciências Farmacêuticas, Departamento de Análises Clínicas, Escola de Farmácia, Universidade Federal de Ouro Preto, Campus Morro do Cruzeiro, Ouro Preto, Minas Gerais, 35400-000, Brazil. |
| المصدر: | Clinical nutrition ESPEN [Clin Nutr ESPEN] 2020 Aug; Vol. 38, pp. 223-228. Date of Electronic Publication: 2020 May 04. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101654592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4577 (Electronic) Linking ISSN: 24054577 NLM ISO Abbreviation: Clin Nutr ESPEN Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Oxford] : Elsevier Ltd., [2015]- |
| مواضيع طبية MeSH: | Uterine Cervical Neoplasms* , Uterine Cervical Dysplasia*/diagnosis, Female ; Folic Acid ; Humans ; Vitamin B 12 |
| مستخلص: | Background & Aims: Diet and lifestyle play an important role in etiology of various tumors. Serum concentration of folate and vitamin B12may be associated with carcinogenesis since they are involved in DNA methylation and nucleotide synthesis. However, the role of these micronutrients on development of cervical cancer is still controversial. Thus, the aim of this study was to analyze the association of lower status of folate and vitamin B12 with the risk of pre-neoplastic cervical lesions. Methods: Our sample group was divided in Control group (n = 120) - women with normal cytology, and Case groups (n = 57) - women presenting Atypical Squamous Cells of Undetermined Significance (ASC-US, n = 21), Low Grade Squamous Intraepithelial Lesion (LSIL; n = 16), and High-Grade lesions (n = 20). We obtained cervical samples for cytology analysis and HPV detection, and blood samples for evaluation of serum concentration of folate and vitamin B12. Results: No difference of serum folate was observed among Cases and Control groups. On the other hand, women with High-Grade lesions presented significant lower median concentration of vitamin B12 if compared to another groups. Then, we observed increased risk of High-Grade lesions among participants with low vitamin B12 levels was observed in relation to women that presented high levels of the micronutrient and from Control group [OR (95% CI): 2.09 (0.65-6.76), p = 0.216], ASC-US [OR (95% CI): 3.15 (0.82-12.08), p = 0.095], and LSIL [OR (95% CI): 3.10 (0.76-12.70), p = 0.116]. Conclusions: Low concentration of vitamin B12 was associated with an increased risk of High-Grade cervical lesions. Besides, we did not observe any difference of serum folate among women with normal cytology and women with pre-neoplastic cervical lesions. Competing Interests: Declaration of Competing Interest There is no conflict of interest. (Copyright © 2020 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cervical cancer; Folate; HPV; Vitamin B12 |
| المشرفين على المادة: | 935E97BOY8 (Folic Acid) P6YC3EG204 (Vitamin B 12) |
| تواريخ الأحداث: | Date Created: 20200722 Date Completed: 20210924 Latest Revision: 20221207 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.clnesp.2020.04.007 |
| PMID: | 32690162 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 2405-4577 |
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| DOI: | 10.1016/j.clnesp.2020.04.007 |