Diet-induced rodent models of obesity-related metabolic disorders-A guide to a translational perspective.

التفاصيل البيبلوغرافية
العنوان:	Diet-induced rodent models of obesity-related metabolic disorders-A guide to a translational perspective.
المؤلفون:	Preguiça I; Institute of Pharmacology and Experimental Therapeutics, and Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Alves A; Institute of Pharmacology and Experimental Therapeutics, and Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Nunes S; Institute of Pharmacology and Experimental Therapeutics, and Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Fernandes R; Institute of Pharmacology and Experimental Therapeutics, and Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal., Gomes P; Institute of Pharmacology and Experimental Therapeutics, and Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal.; Department of Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal.; Center for Health Technology and Services Research (CINTESIS), University of Porto, Porto, Portugal., Viana SD; Institute of Pharmacology and Experimental Therapeutics, and Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal.; ESTESC-Coimbra Health School, Pharmacy, Polytechnic Institute of Coimbra, Coimbra, Portugal., Reis F; Institute of Pharmacology and Experimental Therapeutics, and Coimbra Institute for Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal.; Center for Innovative Biomedicine and Biotechnology (CIBB), University of Coimbra, Coimbra, Portugal.; Clinical Academic Center of Coimbra (CACC), University of Coimbra, Coimbra, Portugal.
المصدر:	Obesity reviews : an official journal of the International Association for the Study of Obesity [Obes Rev] 2020 Dec; Vol. 21 (12), pp. e13081. Date of Electronic Publication: 2020 Jul 20.
نوع المنشور:	Journal Article; Research Support, Non-U.S. Gov't; Review
اللغة:	English
بيانات الدورية:	Publisher: Blackwell Publishing Country of Publication: England NLM ID: 100897395 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1467-789X (Electronic) Linking ISSN: 14677881 NLM ISO Abbreviation: Obes Rev Subsets: MEDLINE
أسماء مطبوعة:	Publication: <2002->: Oxford, UK : Blackwell Publishing Original Publication: Oxford, UK : Blackwell Science, c2000-
مواضيع طبية MeSH:	Metabolic Diseases/etiology , Metabolic Syndrome/etiology , Non-alcoholic Fatty Liver Disease/etiology , Obesity/etiology, Animals ; Diet ; Disease Models, Animal ; Rodentia
مستخلص:	Diet is a critical element determining human health and diseases, and unbalanced food habits are major risk factors for the development of obesity and related metabolic disorders. Despite technological and pharmacological advances, as well as intensification of awareness campaigns, the prevalence of metabolic disorders worldwide is still increasing. Thus, novel therapeutic approaches with increased efficacy are urgently required, which often depends on cellular and molecular investigations using robust animal models. In the absence of perfect rodent models, those induced by excessive consumption of fat and sugars better replicate the key aspects that are the root causes of human metabolic diseases. However, the results obtained using these models cannot be directly compared, particularly because of the use of different dietary protocols, and animal species and strains, among other confounding factors. This review article revisits diet-induced models of obesity and related metabolic disorders, namely, metabolic syndrome, prediabetes, diabetes and nonalcoholic fatty liver disease. A critical analysis focused on the main pathophysiological features of rodent models, as opposed to the criteria defined for humans, is provided as a practical guide with a translational perspective for the establishment of animal models of obesity-related metabolic diseases. (© 2020 World Obesity Federation.)
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فهرسة مساهمة:	Keywords: diabetes; diet-induced rodent models; metabolic syndrome; nonalcoholic fatty liver disease; obesity; prediabetes
تواريخ الأحداث:	Date Created: 20200722 Date Completed: 20210903 Latest Revision: 20210903
رمز التحديث:	20221213
DOI:	10.1111/obr.13081
PMID:	32691524
قاعدة البيانات:	MEDLINE

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تدمد:	1467-789X
DOI:	10.1111/obr.13081