دورية أكاديمية
Transcriptomic profiling identifies novel transcripts, isomorphs, and noncoding RNAs in Paracoccidioides brasiliensis.
| العنوان: | Transcriptomic profiling identifies novel transcripts, isomorphs, and noncoding RNAs in Paracoccidioides brasiliensis. |
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| المؤلفون: | Menegidio FB; Núcleo Integrado de Biotecnologia, Universidade de Mogi das Cruzes (UMC), Brazil., Aciole Barbosa D; Núcleo Integrado de Biotecnologia, Universidade de Mogi das Cruzes (UMC), Brazil., Alencar VC; Núcleo Integrado de Biotecnologia, Universidade de Mogi das Cruzes (UMC), Brazil.; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), Brazil., Vilas Boas RO; Núcleo Integrado de Biotecnologia, Universidade de Mogi das Cruzes (UMC), Brazil., Costa de Oliveira R; Núcleo Integrado de Biotecnologia, Universidade de Mogi das Cruzes (UMC), Brazil., Jabes DL; Núcleo Integrado de Biotecnologia, Universidade de Mogi das Cruzes (UMC), Brazil., Nunes LR; Centro de Ciências Naturais e Humanas, Universidade Federal do ABC (UFABC), Brazil. |
| المصدر: | Medical mycology [Med Mycol] 2021 Feb 04; Vol. 59 (2), pp. 197-200. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 9815835 Publication Model: Print Cited Medium: Internet ISSN: 1460-2709 (Electronic) Linking ISSN: 13693786 NLM ISO Abbreviation: Med Mycol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2014- : Oxford : Oxford University Press Original Publication: Oxford : Blackwell Science, c1998- |
| مواضيع طبية MeSH: | Gene Expression Profiling*, Paracoccidioides/*genetics , RNA, Untranslated/*genetics, Genome, Fungal ; Humans ; Paracoccidioides/pathogenicity ; Paracoccidioidomycosis/microbiology ; Sequence Analysis, RNA ; Transcriptome |
| مستخلص: | This paper describes a transcriptomic profiling of Paracoccidioides brasiliensis (Pb) performed with the aid of an RNA-seq-based approach, aimed at characterizing the general transcriptome in this human pathogenic fungus, responsible for paracoccidioidomycosis (PCM). Results confirm that ∼75% of the genes currently annotated in the P. brasiliensis genome are, in fact, transcribed in vivo and that ∼19% of them may display alternative isomorphs. Moreover, we identified 627 transcripts that do not match any gene currently mapped in the genome, represented by 114 coding transcripts (probably derived from previously unmapped protein-coding genes) and 513 noncoding RNAs (ncRNAs), including 203 long-noncoding RNAs (lncRNAs). (© The Author(s) 2020. Published by Oxford University Press on behalf of The International Society for Human and Animal Mycology.) |
| فهرسة مساهمة: | Keywords: Paracoccidioides brasiliensis; lncRNAs; ncRNA; transcription isomorphs; transcriptome |
| المشرفين على المادة: | 0 (RNA, Untranslated) |
| تواريخ الأحداث: | Date Created: 20200722 Date Completed: 20210827 Latest Revision: 20210827 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1093/mmy/myaa062 |
| PMID: | 32692810 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1460-2709 |
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| DOI: | 10.1093/mmy/myaa062 |