دورية أكاديمية
Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals.
| العنوان: | Reduced Duration of Postchikungunya Musculoskeletal Pain in Rheumatological Patients Treated with Biologicals. |
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| المؤلفون: | de Brito CAA; Internal Medicine, Clinical Hospital of Federal University of Pernambuco and Autoimmune Institute, Recife, Pernambuco, Brazil., Marques CDL; Rheumatology Service, Clinical Hospital of Federal University of Pernambuco, Recife, Pernambuco, Brazil., França RFO; Department of Virology and Experimental Therapy, Aggeu Magalhães Institute, Oswaldo Cruz Foundation (FIOCRUZ), Recife, Pernambuco, Brazil., Monteiro JR; Federal University of Pernambuco, Recife, Pernambuco, Brazil., de Brito MCM; Federal University of Pernambuco, Recife, Pernambuco, Brazil., Lopes F; Federal University of Pernambuco, Recife, Pernambuco, Brazil., Lima A; Federal University of Pernambuco, Recife, Pernambuco, Brazil., Marques GL; Universidade Católica de Pernambuco (UNICAP), Recife, Pernambuco, Brazil., Valadares ML; Faculdade de Medicina de Olinda (FMO), Olinda, Pernambuco, Brazil., Duarte ALBP; Rheumatology Service, Clinical Hospital of Federal University of Pernambuco, Recife, Pernambuco, Brazil. |
| المصدر: | Journal of tropical medicine [J Trop Med] 2020 Jul 10; Vol. 2020, pp. 2071325. Date of Electronic Publication: 2020 Jul 10 (Print Publication: 2020). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: Egypt NLM ID: 101524194 Publication Model: eCollection Cited Medium: Print ISSN: 1687-9686 (Print) Linking ISSN: 16879686 NLM ISO Abbreviation: J Trop Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Cairo, Egypt : Hindawi Pub. Corp. |
| مستخلص: | Chikungunya fever (CHIK) has caused important epidemic outbreaks in the Americas, with musculoskeletal involvement being the main manifestation, causing chronic symptoms in half of the affected patients. This study was performed to evaluate the clinical course of the infection in 168 patients with autoimmune inflammatory disease using biological disease-modifying antirheumatic drugs (bDMARDs), comparing this group with 56 household controls. Anti-CHIKV IgG serology was positive in 42 (25%) of the patients in the bDMARD group and in 15 (27%) of the controls ( p =0.79). Of those with positive serology, 32 (76%) and 14 (93%) were symptomatic among subjects in the bDMARD and control groups, respectively ( p =0.87). Persistence of musculoskeletal symptoms for more than three months occurred in 64% of the patients in the control group and only in 28% in the bDMARD group ( p =0.021), maintaining a statistically significant difference only for users of anti-TNF. This study found that patients affected by chikungunya fever using bDMARDs did not present severe forms or complications in the acute phase of the disease, and patients using anti-TNF biologicals had a lower frequency of chronic joint symptoms than the household controls. This favorable outcome may be related to the cytokine blockade, with a reduction in the inflammatory response and joint damage. Competing Interests: The authors declare that they have no conflicts of interest. (Copyright © 2020 Carlos A. A. de Brito et al.) |
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| تواريخ الأحداث: | Date Created: 20200723 Latest Revision: 20200928 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7368942 |
| DOI: | 10.1155/2020/2071325 |
| PMID: | 32695184 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1687-9686 |
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| DOI: | 10.1155/2020/2071325 |