دورية أكاديمية

The Diverse Roles of the Mucin Gene Cluster Located on Chromosome 11p15.5 in Colorectal Cancer.

التفاصيل البيبلوغرافية
العنوان: The Diverse Roles of the Mucin Gene Cluster Located on Chromosome 11p15.5 in Colorectal Cancer.
المؤلفون: Gan GL; Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China., Liu J; Changjiang Scholar's Laboratory/Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Shantou University Medical College, Shantou, China.; Department of Physiology/Cancer Research Center, Shantou University Medical College, Shantou, China., Chen WJ; Changjiang Scholar's Laboratory/Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Shantou University Medical College, Shantou, China.; Department of Physiology/Cancer Research Center, Shantou University Medical College, Shantou, China., Ye QQ; Changjiang Scholar's Laboratory/Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Shantou University Medical College, Shantou, China.; Department of Physiology/Cancer Research Center, Shantou University Medical College, Shantou, China., Xu Y; Changjiang Scholar's Laboratory/Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Shantou University Medical College, Shantou, China., Wu HT; Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China., Li W; Department of General Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.
المصدر: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2020 Jun 30; Vol. 8, pp. 514. Date of Electronic Publication: 2020 Jun 30 (Print Publication: 2020).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Media S.A., [2013]-
مستخلص: Colorectal cancer (CRC), the third most common malignant tumor in the world, shows multiple complex and pathologies based on the impaired structure and function of the intestinal mucosal barrier. Goblet cells secrete mucins, which are involved in the formation of the intestinal mucosal barrier and not only lubricate and protect the intestinal mucosa but also participate in the processes of cell adhesion, intercellular signal transduction, and immune regulation. It is accepted that the disordered expression and dysfunction of mucins are associated with the occurrence and development of CRC. This article focuses on the secretory mucins encoded by a gene cluster located on chromosome 11p15.5 and systematically reviews their composition, regulation, function, and role in CRC, to deepen the understanding of the pathogeneses of CRC and to provide a new basis and ideas for the treatment of CRC.
(Copyright © 2020 Gan, Liu, Chen, Ye, Xu, Wu and Li.)
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فهرسة مساهمة: Keywords: cell adhesion; colorectal cancer; dysfunction; mucin; occurrence
تواريخ الأحداث: Date Created: 20200723 Latest Revision: 20200928
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7338833
DOI: 10.3389/fcell.2020.00514
PMID: 32695780
قاعدة البيانات: MEDLINE
الوصف
تدمد:2296-634X
DOI:10.3389/fcell.2020.00514