دورية أكاديمية
Dual local drug delivery of vancomycin and farnesol for mitigation of MRSA infection in vivo - a pilot study.
| العنوان: | Dual local drug delivery of vancomycin and farnesol for mitigation of MRSA infection in vivo - a pilot study. |
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| المؤلفون: | Woelfle UC, Briggs T, Bhattacharyya S, Qu H, Sheth N, Knabe C; Department of Experimental Orofacial Medicine, Philipps University, Marburg, Germany.knabec@med.uni-marburg.de., Ducheyne P |
| المصدر: | European cells & materials [Eur Cell Mater] 2020 Jul 16; Vol. 40, pp. 38-57. Date of Electronic Publication: 2020 Jul 16. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Forum Multimedia Publishing LLC Country of Publication: Switzerland NLM ID: 100973416 Publication Model: Electronic Cited Medium: Internet ISSN: 1473-2262 (Electronic) Linking ISSN: 14732262 NLM ISO Abbreviation: Eur Cell Mater Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : Charlottesville, VA : Forum Multimedia Publishing LLC Original Publication: [Glasgow] Scotland : European Cells & Materials, [2001]- |
| مواضيع طبية MeSH: | Drug Delivery Systems*, Farnesol/*pharmacology , Methicillin-Resistant Staphylococcus aureus/*drug effects , Staphylococcal Infections/*drug therapy , Staphylococcal Infections/*microbiology , Vancomycin/*pharmacology, Animals ; Bone and Bones/diagnostic imaging ; Bone and Bones/microbiology ; Bone and Bones/pathology ; Coated Materials, Biocompatible/pharmacology ; Farnesol/administration & dosage ; Farnesol/therapeutic use ; Male ; Pilot Projects ; Rats, Sprague-Dawley ; Staphylococcal Infections/diagnostic imaging ; Vancomycin/administration & dosage ; Vancomycin/therapeutic use ; X-Ray Microtomography |
| مستخلص: | Surgical site infections after orthopaedic surgery using fracture fixation devices or endosseous implants create major surgical challenges with severe adverse effects, such as osteomyelitis. These infections are frequently caused by Staphylococcus aureus, often with high resistance to antibiotics, such as methicillin-resistant Staphylococcus aureus (MRSA). Due to the formation of impenetrable biofilms on implant surfaces, systemic antibiotic treatment has become exceedingly difficult. New solutions are pursued by combining several drugs using a controlled delivery system from specifically engineered implant surfaces. A sol-gel coating on titanium implants was previously developed with 20 wt % vancomycin and 30 wt % farnesol, with suppression of MRSA in vitro. The present study investigated the efficacy of sol-gel film coatings for controlled dual local delivery over 4 weeks utilising a rat infection model. The findings confirmed the viability of this new concept in vivo based on the differences observed between coatings containing vancomycin alone (SGV) and the dual-drug-containing coating with vancomycin and farnesol (SGVF). While both the SGVF and SGV coatings facilitated excellent preservation of the osseous microarchitecture, SGVF coating displayed a slightly higher potency for suppressing MRSA infiltration than SGV, in combination with a lower reactive bone remodelling activity, most likely by disturbing biofilm formation. The next step for advancing the concept of dual-drug delivery from sol-gel coatings to the clinic and confirming the promising effect of the SGVF coatings on reactive bone remodelling and suppressing MRSA infiltration is a study in a larger animal species with longer time points. |
| المشرفين على المادة: | 0 (Coated Materials, Biocompatible) 4602-84-0 (Farnesol) 6Q205EH1VU (Vancomycin) |
| تواريخ الأحداث: | Date Created: 20200723 Date Completed: 20210825 Latest Revision: 20210825 |
| رمز التحديث: | 20231215 |
| DOI: | 10.22203/eCM.v040a03 |
| PMID: | 32696976 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1473-2262 |
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| DOI: | 10.22203/eCM.v040a03 |