دورية أكاديمية
Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis.
| العنوان: | Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis. |
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| المؤلفون: | Codo AC; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Davanzo GG; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Monteiro LB; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., de Souza GF; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Muraro SP; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Virgilio-da-Silva JV; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Prodonoff JS; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Carregari VC; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., de Biagi Junior CAO; Department of Genetics at Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil., Crunfli F; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Jimenez Restrepo JL; Department of Clinical and Toxicological analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Vendramini PH; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Reis-de-Oliveira G; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Bispo Dos Santos K; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Toledo-Teixeira DA; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Parise PL; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Martini MC; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Marques RE; Brazilian Biosciences National Laboratory (LNBio), Campinas, São Paulo, Brazil., Carmo HR; Department of Clinical Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Borin A; Brazilian Biosciences National Laboratory (LNBio), Campinas, São Paulo, Brazil., Coimbra LD; Brazilian Biosciences National Laboratory (LNBio), Campinas, São Paulo, Brazil., Boldrini VO; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Brunetti NS; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Vieira AS; Department of Animal Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Mansour E; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Ulaf RG; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Bernardes AF; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Nunes TA; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Ribeiro LC; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Palma AC; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Agrela MV; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Moretti ML; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Sposito AC; Department of Clinical Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil., Pereira FB; Hematology and Hemotherapy Center University of Campinas, Campinas, São Paulo, Brazil., Velloso LA; Department of Internal Medicine, School of Medical Sciences, University of Campinas, Campinas, São Paulo, Brazil; Obesity and Comorbidities Research Center (OCRC), University of Campinas, São Paulo, Brazil., Vinolo MAR; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil., Damasio A; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil., Proença-Módena JL; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil., Carvalho RF; Department of Structural and Functional Biology, Institute of Biosciences, São Paulo State University (UNESP), Botucatu, São Paulo, Brazil., Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Obesity and Comorbidities Research Center (OCRC), University of Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil., Martins-de-Souza D; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil; D'Or Institute for Research and Education (IDOR), São Paulo, Brazil; Instituto Nacional de Biomarcadores em Neuropsiquiatria, Conselho Nacional de Desenvolvimento Científico e Tecnológico, São Paulo, Brazil., Nakaya HI; Department of Clinical and Toxicological analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil., Farias AS; Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil., Moraes-Vieira PM; Laboratory of Immunometabolism, Department of Genetics, Evolution, Microbiology and Immunology, Institute of Biology, University of Campinas, Campinas, São Paulo, Brazil; Obesity and Comorbidities Research Center (OCRC), University of Campinas, São Paulo, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, São Paulo, Brazil. Electronic address: pmvieira@unicamp.br. |
| المصدر: | Cell metabolism [Cell Metab] 2020 Sep 01; Vol. 32 (3), pp. 437-446.e5. Date of Electronic Publication: 2020 Jul 17. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge, Mass. : Cell Press, c2005- |
| مواضيع طبية MeSH: | Betacoronavirus/*physiology , Blood Glucose/*metabolism , Coronavirus Infections/*complications , Diabetes Complications/*complications , Hypoxia-Inducible Factor 1, alpha Subunit/*metabolism , Monocytes/*metabolism , Pneumonia, Viral/*complications, Adult ; COVID-19 ; Cell Line ; Coronavirus Infections/metabolism ; Diabetes Complications/metabolism ; Diabetes Mellitus/metabolism ; Female ; Glycolysis ; Humans ; Inflammation/complications ; Inflammation/metabolism ; Male ; Middle Aged ; Monocytes/virology ; Pandemics ; Pneumonia, Viral/metabolism ; Reactive Oxygen Species/metabolism ; SARS-CoV-2 ; Signal Transduction |
| مستخلص: | COVID-19 can result in severe lung injury. It remained to be determined why diabetic individuals with uncontrolled glucose levels are more prone to develop the severe form of COVID-19. The molecular mechanism underlying SARS-CoV-2 infection and what determines the onset of the cytokine storm found in severe COVID-19 patients are unknown. Monocytes and macrophages are the most enriched immune cell types in the lungs of COVID-19 patients and appear to have a central role in the pathogenicity of the disease. These cells adapt their metabolism upon infection and become highly glycolytic, which facilitates SARS-CoV-2 replication. The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1α (HIF-1α) and consequently promotes glycolysis. HIF-1α-induced changes in monocyte metabolism by SARS-CoV-2 infection directly inhibit T cell response and reduce epithelial cell survival. Targeting HIF-1ɑ may have great therapeutic potential for the development of novel drugs to treat COVID-19. Competing Interests: Declaration of Interests Authors declare no competing interests. (Copyright © 2020 Elsevier Inc. All rights reserved.) |
| التعليقات: | Comment in: Nat Rev Immunol. 2020 Aug;20(8):460. (PMID: 32533110) Erratum in: Cell Metab. 2020 Sep 1;32(3):498-499. (PMID: 32877692) Comment in: Signal Transduct Target Ther. 2021 Mar 6;6(1):112. (PMID: 33677470) |
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| فهرسة مساهمة: | Keywords: Covid-19; HIF-1alpha; SARS-CoV-2; diabetes; glycolysis; inflammation; interferon; metabolism; mitochondria; monocyte |
| المشرفين على المادة: | 0 (Blood Glucose) 0 (HIF1A protein, human) 0 (Hypoxia-Inducible Factor 1, alpha Subunit) 0 (Reactive Oxygen Species) |
| تواريخ الأحداث: | Date Created: 20200723 Date Completed: 20200915 Latest Revision: 20210309 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC7367032 |
| DOI: | 10.1016/j.cmet.2020.07.007 |
| PMID: | 32697943 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1932-7420 |
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| DOI: | 10.1016/j.cmet.2020.07.007 |