دورية أكاديمية
Major CYP450 Polymorphism among Saudi Patients.
العنوان: | Major CYP450 Polymorphism among Saudi Patients. |
---|---|
المؤلفون: | Almeman AA; Clinical Pharmacology and Therapeutics Department, Qassim University, Buraydah, Qassim, Saudi Arabia. |
المصدر: | Drug metabolism letters [Drug Metab Lett] 2021; Vol. 14 (1), pp. 17-24. |
نوع المنشور: | Journal Article; Systematic Review |
اللغة: | English |
بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101313587 Publication Model: Print Cited Medium: Internet ISSN: 1874-0758 (Electronic) Linking ISSN: 18723128 NLM ISO Abbreviation: Drug Metab Lett Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers |
مواضيع طبية MeSH: | Cytochrome P-450 Enzyme System*/genetics , Genetics, Population* , Polymorphism, Genetic*, ATP Binding Cassette Transporter, Subfamily B/genetics ; Adolescent ; Adult ; Aged ; Cytochrome P-450 CYP2C19/genetics ; Cytochrome P-450 CYP2C9/genetics ; Cytochrome P-450 CYP2D6/genetics ; Gene Frequency ; Genotype ; Humans ; Middle Aged ; Saudi Arabia ; Young Adult |
مستخلص: | Background: Cytochrome P450 (CYP) contributes to a huge collection of medicinal products' Phase I metabolization. We aimed to summarize and investigate the current evidence regarding the frequency of CYP2D6, CYP2C9, CYP2C19, and MDR1 in Saudi Arabia. Methods: A computerized search in four databases was done using the relevant keywords. The screening process was done in two steps; title and abstract screening and full-text screening. Data of demographic and characteristics of included studies and patients were extracted and tabulated. Results: Ten studies were eligible for our criteria and were included in this systematic review. The age of participants ranged between 17-65 years. Only two subjects showed PM phenotype of CYP2C19 in the Saudi population. The most frequent alleles were CYP2C19*1 (62.9%), CYP2C19*2 (11.2%-32%), and CYP2C19*17 (25.7%). The CYP2C19 Conclusion: The current evidence suggests that Saudi resembled European in the frequency of CYP2C19, Caucasians in both the incidence of CYP2C9 and CYP2C19 (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.) |
فهرسة مساهمة: | Keywords: CYP2C19; CYP2C9; CYP2D6; Cytochrome P450 (CYP).; MDR1; Saudis; polymorphism |
المشرفين على المادة: | 0 (ABCB1 protein, human) 0 (ATP Binding Cassette Transporter, Subfamily B) 9035-51-2 (Cytochrome P-450 Enzyme System) EC 1.14.13.- (Cytochrome P-450 CYP2C9) EC 1.14.14.1 (Cytochrome P-450 CYP2C19) EC 1.14.14.1 (Cytochrome P-450 CYP2D6) |
تواريخ الأحداث: | Date Created: 20200725 Date Completed: 20220126 Latest Revision: 20220531 |
رمز التحديث: | 20221213 |
DOI: | 10.2174/1872312814666200722122232 |
PMID: | 32703145 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1874-0758 |
---|---|
DOI: | 10.2174/1872312814666200722122232 |