دورية أكاديمية
أعرض في EDS

Major CYP450 Polymorphism among Saudi Patients.

التفاصيل البيبلوغرافية
العنوان: Major CYP450 Polymorphism among Saudi Patients.
المؤلفون: Almeman AA; Clinical Pharmacology and Therapeutics Department, Qassim University, Buraydah, Qassim, Saudi Arabia.
المصدر: Drug metabolism letters [Drug Metab Lett] 2021; Vol. 14 (1), pp. 17-24.
نوع المنشور: Journal Article; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101313587 Publication Model: Print Cited Medium: Internet ISSN: 1874-0758 (Electronic) Linking ISSN: 18723128 NLM ISO Abbreviation: Drug Metab Lett Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers
مواضيع طبية MeSH: Cytochrome P-450 Enzyme System*/genetics , Genetics, Population* , Polymorphism, Genetic*, ATP Binding Cassette Transporter, Subfamily B/genetics ; Adolescent ; Adult ; Aged ; Cytochrome P-450 CYP2C19/genetics ; Cytochrome P-450 CYP2C9/genetics ; Cytochrome P-450 CYP2D6/genetics ; Gene Frequency ; Genotype ; Humans ; Middle Aged ; Saudi Arabia ; Young Adult
مستخلص: Background: Cytochrome P450 (CYP) contributes to a huge collection of medicinal products' Phase I metabolization. We aimed to summarize and investigate the current evidence regarding the frequency of CYP2D6, CYP2C9, CYP2C19, and MDR1 in Saudi Arabia.
Methods: A computerized search in four databases was done using the relevant keywords. The screening process was done in two steps; title and abstract screening and full-text screening. Data of demographic and characteristics of included studies and patients were extracted and tabulated.
Results: Ten studies were eligible for our criteria and were included in this systematic review. The age of participants ranged between 17-65 years. Only two subjects showed PM phenotype of CYP2C19 in the Saudi population. The most frequent alleles were CYP2C19*1 (62.9%), CYP2C19*2 (11.2%-32%), and CYP2C19*17 (25.7%). The CYP2C19 m1 was observed in 97 cases of extensive metabolizing (EM) phenotype CYP2C19. Concerning the CYP2C9, the most frequent alleles were CYP2C9*1 and CYP2C9*2, and the most frequent genotype was CYP2C9*1*1. The CYP2D6*41 allele and C1236T MDR1 were the most frequent allele in this population.
Conclusion: The current evidence suggests that Saudi resembled European in the frequency of CYP2C19, Caucasians in both the incidence of CYP2C9 and CYP2C19 m1 , and the absence of CYP2C19 m2 . The CYP2D6*41 allele frequency in Saudi is relatively high. We recommend further research to evaluate the basic and clinical relevance of gene polymorphism in such ethnicity.
(Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
فهرسة مساهمة: Keywords: CYP2C19; CYP2C9; CYP2D6; Cytochrome P450 (CYP).; MDR1; Saudis; polymorphism
المشرفين على المادة: 0 (ABCB1 protein, human)
0 (ATP Binding Cassette Transporter, Subfamily B)
9035-51-2 (Cytochrome P-450 Enzyme System)
EC 1.14.13.- (Cytochrome P-450 CYP2C9)
EC 1.14.14.1 (Cytochrome P-450 CYP2C19)
EC 1.14.14.1 (Cytochrome P-450 CYP2D6)
تواريخ الأحداث: Date Created: 20200725 Date Completed: 20220126 Latest Revision: 20220531
رمز التحديث: 20221213
DOI: 10.2174/1872312814666200722122232
PMID: 32703145
قاعدة البيانات: MEDLINE
الوصف
تدمد:1874-0758
DOI:10.2174/1872312814666200722122232