دورية أكاديمية
Surgery for Men with Breast Cancer: Do the Same Data Still Apply?
| العنوان: | Surgery for Men with Breast Cancer: Do the Same Data Still Apply? |
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| المؤلفون: | Plichta JK; Department of Surgery, Duke University Medical Center, Durham, NC, USA. jennifer.plichta@duke.edu.; Duke Cancer Institute, Durham, NC, USA. jennifer.plichta@duke.edu., Ren Y; Duke Cancer Institute, Durham, NC, USA., Marks CE; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Thomas SM; Duke Cancer Institute, Durham, NC, USA.; Department of Biostatistics & Bioinformatics, Duke University, Durham, NC, USA., Greenup RA; Department of Surgery, Duke University Medical Center, Durham, NC, USA.; Duke Cancer Institute, Durham, NC, USA., Rosenberger LH; Department of Surgery, Duke University Medical Center, Durham, NC, USA.; Duke Cancer Institute, Durham, NC, USA., Fayanju OM; Department of Surgery, Duke University Medical Center, Durham, NC, USA.; Duke Cancer Institute, Durham, NC, USA.; Department of Surgery, Durham VA Medical Center, Durham, NC, USA., McDuff SGR; Duke Cancer Institute, Durham, NC, USA.; Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA., Hwang ES; Department of Surgery, Duke University Medical Center, Durham, NC, USA.; Duke Cancer Institute, Durham, NC, USA., Force J; Duke Cancer Institute, Durham, NC, USA.; Department of Medicine, Duke University Medical Center, Durham, NC, USA. |
| المصدر: | Annals of surgical oncology [Ann Surg Oncol] 2020 Nov; Vol. 27 (12), pp. 4720-4729. Date of Electronic Publication: 2020 Jul 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 9420840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4681 (Electronic) Linking ISSN: 10689265 NLM ISO Abbreviation: Ann Surg Oncol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : New York, NY : Springer Original Publication: New York, NY : Raven Press, c1994- |
| مواضيع طبية MeSH: | Breast Neoplasms, Male*/surgery, Aged ; Humans ; Lymph Node Excision ; Male ; Mastectomy ; Mastectomy, Segmental ; Middle Aged ; Neoplasm Staging ; Sentinel Lymph Node Biopsy |
| مستخلص: | Background: Men represent a small proportion of breast cancer diagnoses, and they are often excluded from clinical trials. Current treatments are largely extrapolated from evidence in women. We compare practice patterns between men and women with breast cancer following the publication of several landmark clinical trials in surgery. Patients and Methods: Patients with invasive breast cancer (2004-2015) from the National Cancer Data Base were identified; subcohorts were created based on eligibility for NSABP-B06, CALGB 9343, and ACOSOG Z0011. Practice patterns were stratified by gender and compared. Cox proportional hazards regression analyses were utilized to estimate the association between OS and gender. Results: Of the 1,664,746 patients identified, 99% were women and 1% were men. Among NSABP-B06 eligible men, mastectomy rates did not change (consistently ~ 80%), and their adjusted OS was minimally worse compared with women (HR 1.19, 95% CI 1.11-1.28). Following publication of CALGB 9343, omission of radiation after lumpectomy was less likely in men and lagged behind that of women, despite similar OS (male HR 0.92, 95% CI 0.59-1.44). Application of ACOSOG Z0011 findings resulted in deescalation of axillary surgery for men and women with comparable OS (male HR 0.69, 95% CI 0.33-1.45). Conclusions: Uptake of clinical trial results for men with breast cancer often mirrors that for women, despite exclusion from these studies. Furthermore, when study findings were applied to eligible patients, men and women demonstrated similar survival. Observational studies can help inform the potential application of study findings to this unique population and improve patient enrollment in clinical trials. |
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| معلومات مُعتمدة: | K08 CA241390 United States CA NCI NIH HHS; P30 CA014236 United States CA NCI NIH HHS; P30CA014236 United States NH NIH HHS; 1K08CA241390 United States NH NIH HHS |
| فهرسة مساهمة: | Keywords: Breast radiation; Breast surgery; Local–regional therapy; Male breast cancer |
| تواريخ الأحداث: | Date Created: 20200725 Date Completed: 20210504 Latest Revision: 20211102 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC7554146 |
| DOI: | 10.1245/s10434-020-08901-z |
| PMID: | 32705510 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1534-4681 |
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| DOI: | 10.1245/s10434-020-08901-z |