دورية أكاديمية
Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats.
| العنوان: | Cytoprotective and antisecretory properties of methanolic extract of Distemonanthus benthamianus (Caesalpiniaceae) stem bark on acute gastric ulcer in rats. |
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| المؤلفون: | Matah Marthe VM; Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon., Ateufack G; Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon., Mbiantcha M; Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon., Nana WY; Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon., Atsamo AD; Laboratory of Animal Physiology, Faculty of Science, University of Yaounde I, Yaoundé, Cameroon., Adjouzem FC; Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon., Djuichou Nguemnang FS; Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon., Tsafack GE; Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon., Tadjoua HT; Research Unit of Animal Physiology and Phytopharmacology, Faculty of Science, University of Dschang, Dschang, Cameroon., Emakoua J; Department of Biological Sciences, Higher Teachers' Training College, University of Yaounde I, Yaounde, Cameroon. |
| المصدر: | Journal of complementary & integrative medicine [J Complement Integr Med] 2020 Jul 24; Vol. 18 (1), pp. 37-49. Date of Electronic Publication: 2020 Jul 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Walter de Gruyter Country of Publication: Germany NLM ID: 101313855 Publication Model: Electronic Cited Medium: Internet ISSN: 1553-3840 (Electronic) Linking ISSN: 15533840 NLM ISO Abbreviation: J Complement Integr Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2012-> : Berlin : Walter de Gruyter Original Publication: Berkeley, Calif. : Berkeley Electronic Press, 2004- |
| مواضيع طبية MeSH: | Caesalpinia*, Anti-Ulcer Agents/*pharmacology , Cryoprotective Agents/*pharmacology , Methanol/*pharmacology , Plant Bark/*chemistry , Plant Extracts/*pharmacology , Stomach Ulcer/*drug therapy, Animals ; Disease Models, Animal ; Ethanol ; Gastric Acid/metabolism ; Gastric Mucosa/drug effects ; Indomethacin ; Male ; Phytotherapy ; Pylorus/drug effects ; Rats ; Rats, Wistar ; Stomach Ulcer/chemically induced |
| مستخلص: | Objectives: In African traditional medicine, Distemonanthus benthamianus (Caesalpiniaceae) is used to treat many diseases including gastric ulcers. We evaluated in this study, the cytoprotective and antisecretory properties of the methanolic extract of the stem bark of this plant using different technics of gastric lesion induction. Methods: Cytoprotective and antisecretory activity of the methanolic extract of D. benthamianus stem bark was evolved through six methods of gastric lesion induction in experimental Wistar male rats (150-200 g): (1) gastric lesions induced by HCl/ethanol, (2) gastric lesions induced by Indomethacin- HCl/ethanol, (3) gastric lesion induced by Indomethacin, (4) gastric lesions induced by Pylorus ligation, (5) gastric lesions induced by histamine-Pylorus ligation, (6) gastric lesions induced by carbachol-Pylorus ligation. Mucus and gastric mucosal ulceration were evaluated. pH, gastric volume, and acidity were quantified in all pylorus ligation induction technics. Nitric oxide (NO) level was determined in indomethacin induced gastric ulcers. Results: At different doses (125, 250 and 500 mg/kg), extract reduced significantly the ulcer index. In all models used, that is 100.00% with HCl/ethanol; 100.00% with HCl/ethanol/indomethacin; 95.70% with Indomethacin; 74.79% with pylorus ligation, 95.94% histamine-Pylorus ligation, 99.54% carbachol-Pylorus ligation at the highest dose of 500 mg/kg. The lesion formation reduces in all the methods used followed by a significant increase of mucus production. The pylorus ligation technic revealed that the extract has an antisecretory activity. Conclusions: The methanolic extract of D. benthamianus stem bark has both cytoprotective and antisecretory effects. This extract exerts its antisecretory effect trough cholinergic and histaminergic pathways. (© 2020 Walter de Gruyter GmbH, Berlin/Boston.) |
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| فهرسة مساهمة: | Keywords: Distemonanthus benthamianus; antisecretion; cytoprotection; gastric ulcers |
| المشرفين على المادة: | 0 (Anti-Ulcer Agents) 0 (Cryoprotective Agents) 0 (Plant Extracts) 3K9958V90M (Ethanol) XXE1CET956 (Indomethacin) Y4S76JWI15 (Methanol) |
| تواريخ الأحداث: | Date Created: 20200725 Date Completed: 20210929 Latest Revision: 20210929 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1515/jcim-2019-0216 |
| PMID: | 32706751 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1553-3840 |
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| DOI: | 10.1515/jcim-2019-0216 |