دورية أكاديمية
أعرض في EDS

MEF2C and HDAC5 regulate Egr1 and Arc genes to increase dendritic spine density and complexity in early enriched environment.

التفاصيل البيبلوغرافية
العنوان: MEF2C and HDAC5 regulate Egr1 and Arc genes to increase dendritic spine density and complexity in early enriched environment.
المؤلفون: Puang SJ; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore., Elanggovan B; Integrative Neuroscience Programme, Singapore Institute for Clinical Sciences, Agency for Science and Technology (ASTAR), Singapore., Ching T; Integrative Neuroscience Programme, Singapore Institute for Clinical Sciences, Agency for Science and Technology (ASTAR), Singapore., Sng JCG; Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
المصدر: Neuronal signaling [Neuronal Signal] 2020 Jul 23; Vol. 4 (3), pp. NS20190147. Date of Electronic Publication: 2020 Jul 23 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Portland Press Limited on behalf of the Biochemical Society Country of Publication: England NLM ID: 101721079 Publication Model: eCollection Cited Medium: Internet ISSN: 2059-6553 (Electronic) Linking ISSN: 20596553 NLM ISO Abbreviation: Neuronal Signal Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: London : Portland Press Limited on behalf of the Biochemical Society, [2017]-
مستخلص: We investigated the effects of environmental enrichment during critical period of early postnatal life and how it interplays with the epigenome to affect experience-dependent visual cortical plasticity. Mice raised in an EE from birth to during CP have increased spine density and dendritic complexity in the visual cortex. EE upregulates synaptic plasticity genes, Arc and Egr1 , and a transcription factor MEF2C. We also observed an increase in MEF2C binding to the promoters of Arc and Egr1 . In addition, pups raised in EE show a reduction in HDAC5 and its binding to promoters of Mef2c, Arc and Egr1 genes. With an overexpression of Mef2c , neurite outgrowth increased in complexity. Our results suggest a possible underlying molecular mechanism of EE, acting through MEF2C and HDAC5, which drive Arc and Egr1. This could lead to the observed increased dendritic spine density and complexity induced by early EE.
Competing Interests: The authors have no relevant affiliations or financial involvement with any organization or entity with a financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
(© 2020 The Author(s).)
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فهرسة مساهمة: Keywords: HDAC5; MEF2C; environmental enrichment; epigenetics; experience dependent plasticity; synaptic plasticity genes
تواريخ الأحداث: Date Created: 20200728 Latest Revision: 20200928
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7378308
DOI: 10.1042/NS20190147
PMID: 32714604
قاعدة البيانات: MEDLINE
الوصف
تدمد:2059-6553
DOI:10.1042/NS20190147