دورية أكاديمية
أعرض في EDS

An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages.

التفاصيل البيبلوغرافية
العنوان: An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages.
المؤلفون: de Vasconcelos NM; Department of Internal Medicine and Pediatrics, Ghent University, 9052 Ghent, Belgium; VIB Center for Inflammation Research, 9052 Ghent, Belgium., Van Opdenbosch N; Department of Internal Medicine and Pediatrics, Ghent University, 9052 Ghent, Belgium; VIB Center for Inflammation Research, 9052 Ghent, Belgium; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse 2340, Belgium., Van Gorp H; Department of Internal Medicine and Pediatrics, Ghent University, 9052 Ghent, Belgium; VIB Center for Inflammation Research, 9052 Ghent, Belgium., Martín-Pérez R; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse 2340, Belgium., Zecchin A; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse 2340, Belgium., Vandenabeele P; VIB Center for Inflammation Research, 9052 Ghent, Belgium; Department of Biomedical Molecular Biology, Ghent University, Ghent 9052, Belgium; Methusalem program, Ghent University, Ghent 9052, Belgium., Lamkanfi M; Department of Internal Medicine and Pediatrics, Ghent University, 9052 Ghent, Belgium; VIB Center for Inflammation Research, 9052 Ghent, Belgium; Janssen Immunosciences, World Without Disease Accelerator, Pharmaceutical Companies of Johnson & Johnson, Beerse 2340, Belgium. Electronic address: mohamed.lamkanfi@ugent.be.
المصدر: Cell reports [Cell Rep] 2020 Jul 28; Vol. 32 (4), pp. 107959.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2012-
مواضيع طبية MeSH: Caspases/*metabolism , Macrophages/*metabolism , Pyroptosis/*physiology, Animals ; Apoptosis/physiology ; Apoptosis Regulatory Proteins/metabolism ; Caspase 1/metabolism ; Caspase 1/physiology ; Caspase 3/metabolism ; Caspase 7/metabolism ; Caspase 8/metabolism ; Caspase 8/physiology ; Cell Death ; Cell Membrane/metabolism ; Female ; Inflammasomes/metabolism ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Phosphate-Binding Proteins/metabolism
مستخلص: Pyroptosis has emerged as a key mechanism by which inflammasomes promote host defense against microbial pathogens and sterile inflammation. Gasdermin D (GSDMD)-mediated cell lysis is a hallmark of pyroptosis, but our understanding of cell death signaling during pyroptosis is fragmented. Here, we show that independently of GSDMD-mediated plasma membrane permeabilization, inflammasome receptors engage caspase-1 and caspase-8, both of which redundantly promote activation of apoptotic executioner caspase-3 and caspase-7 in pyroptotic macrophages. Impaired GSDMD pore formation downstream of caspase-1 and caspase-8 activation suffices to unmask the apoptotic phenotype of pyroptotic macrophages. Combined inactivation of initiator caspase-1 and caspase-8, or executioner caspase-3 and caspase-7, is required to abolish inflammasome-induced DEVDase activity during pyroptosis and in apoptotic Gsdmd -/- cells. Collectively, these results unveil a robust apoptotic caspase network that is activated in parallel to GSDMD-mediated plasma membrane permeabilization and safeguards cell death induction in pyroptotic macrophages.
Competing Interests: Declaration of Interests N.V.O., R.M.-P., A.Z., and M.L. are/were employees of Janssen Pharmaceutica. The authors declare no other competing interests.
(Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: 683144 International ERC_ European Research Council
فهرسة مساهمة: Keywords: GSDMD; apoptosis; caspase-1; caspase-3; caspase-7; caspase-8; inflammasome; pyroptosis
المشرفين على المادة: 0 (Apoptosis Regulatory Proteins)
0 (Gsdmd protein, mouse)
0 (Inflammasomes)
0 (Intracellular Signaling Peptides and Proteins)
0 (Phosphate-Binding Proteins)
EC 3.4.22.- (Casp8 protein, mouse)
EC 3.4.22.- (Caspase 3)
EC 3.4.22.- (Caspase 7)
EC 3.4.22.- (Caspase 8)
EC 3.4.22.- (Caspases)
EC 3.4.22.36 (Casp1 protein, mouse)
EC 3.4.22.36 (Caspase 1)
تواريخ الأحداث: Date Created: 20200730 Date Completed: 20210510 Latest Revision: 20210924
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC7408007
DOI: 10.1016/j.celrep.2020.107959
PMID: 32726624
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-1247
DOI:10.1016/j.celrep.2020.107959