High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients.

التفاصيل البيبلوغرافية
العنوان:	High-dose Cholecalciferol Supplementation Reducing Morning Blood Pressure in Normotensive DM1 Patients.
المؤلفون:	de Queiroz NNM; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Melo FTC; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Souza Resende F; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., Janaú LC; State University of Para, Platter Perebebui, 2623, Marco, Belem 66087-662, Para, Brazil., de Souza Neto NJK; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Lemos MN; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Oliveira MCNI; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Alcântara AL; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Moraes LV; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., da Mota Queiroz A; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Souza ÍJA; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., Said NM; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., Dos Santos MC; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Souza D'Albuquerque Silva L; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., Motta ARB; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Sá Oliveira Dos Reis M; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., Lobato IJC; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Figueiredo PBB; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., de Souza ACCB; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., Freire Piani PP; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., Felício KM; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., Abrahão Neto JF; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil., Felício JS; Endocrinology Division, University Hospital Joao de Barros Barreto, Federal University of Para, Mundurucus Street, 4487, Guama, Belem 66073-000, Para, Brazil.
المصدر:	Current diabetes reviews [Curr Diabetes Rev] 2021; Vol. 17 (3), pp. 378-386.
نوع المنشور:	Journal Article
اللغة:	English
بيانات الدورية:	Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101253260 Publication Model: Print Cited Medium: Internet ISSN: 1875-6417 (Electronic) Linking ISSN: 15733998 NLM ISO Abbreviation: Curr Diabetes Rev Subsets: MEDLINE
أسماء مطبوعة:	Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2005-
مواضيع طبية MeSH:	Cholecalciferol* , Vitamin D Deficiency/complications , Vitamin D Deficiency/drug therapy, Blood Pressure ; Blood Pressure Monitoring, Ambulatory ; Dietary Supplements ; Humans
مستخلص:	Background: Vitamin D (VD) deficiency has been related to several endocrine metabolic and cardiovascular diseases. The effect of VD supplementation on blood pressure (BP) in patients with diabetes is controversial. Objective: The aim of this study was to evaluate high-dose vitamin D supplementation effects on blood pressure of normotensive patients with diabetes mellitus 1 (DM1) patients by 24-hour ambulatory blood pressure monitoring (ABPM). Methods: We performed a clinical trial including 35 DM1 normotensive patients, who received doses of 4,000 or 10,000 IU/day of cholecalciferol for 12 weeks according to previous VD levels. They underwent 24-hour ABPM, along with glycated hemoglobin, creatine, lipids profile and PCRus dosage before and after VD supplementation. Results: We found an expressive reduction of systolic and diastolic morning blood pressures (117±14 vs 112±14, p<0,05; 74±9 vs 70±10 mmHg, p<0,05, respectively) with no changes in other pressoric markers. Besides, we noticed a relationship between levels of VD after supplementation and diastolic morning blood pressure (r= -0,4; p<0.05). Conclusion: Our study suggests an association between supplementation of high doses of vitamin D and the reduction of morning blood pressure in normotensive DM1 patients. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)
فهرسة مساهمة:	Keywords: Diabetes mellitus; ambulatory; blood pressure; blood pressure monitoring; cholecalciferol; type 1; vitamin D
المشرفين على المادة:	1C6V77QF41 (Cholecalciferol)
تواريخ الأحداث:	Date Created: 20200731 Date Completed: 20210325 Latest Revision: 20210325
رمز التحديث:	20240628
DOI:	10.2174/1573399816999200729131508
PMID:	32729423
قاعدة البيانات:	MEDLINE

الوصف
تدمد:	1875-6417
DOI:	10.2174/1573399816999200729131508