دورية أكاديمية
Pfaffia glomerata hydroalcoholic extract stimulates penile tissue in adult Swiss mice.
| العنوان: | Pfaffia glomerata hydroalcoholic extract stimulates penile tissue in adult Swiss mice. |
|---|---|
| المؤلفون: | Dias FCR; Department of General Biology, Federal University of Viçosa, Peter Henry Rolfs Avenue S/n, 36570-900, Viçosa, MG, Brazil; Department of Structural Biology, Federal University of Triângulo Mineiro, Praça Manoel Terra, 330, 38025-015, Uberaba, MG, Brazil., Gomes MLM; Department of Structural Biology, Federal University of Triângulo Mineiro, Praça Manoel Terra, 330, 38025-015, Uberaba, MG, Brazil. Electronic address: marcoslucca@gmail.com., Melo FCSA; Department of Animal Biology, Federal University of Viçosa, Peter Henry Rolfs Avenue S/n, 36570-900, Viçosa, MG, Brazil., Menezes TP; Department of General Biology, Federal University of Viçosa, Peter Henry Rolfs Avenue S/n, 36570-900, Viçosa, MG, Brazil., Martins AL; Department of General Biology, Federal University of Viçosa, Peter Henry Rolfs Avenue S/n, 36570-900, Viçosa, MG, Brazil., Cupertino MDC; Department of General Biology, Federal University of Viçosa, Peter Henry Rolfs Avenue S/n, 36570-900, Viçosa, MG, Brazil., Otoni WC; Department of Plant Biology, Federal University of Viçosa, Peter Henry Rolfs Avenue S/n, 36570-900, Viçosa, MG, Brazil., Matta SLPD; Department of General Biology, Federal University of Viçosa, Peter Henry Rolfs Avenue S/n, 36570-900, Viçosa, MG, Brazil. |
| المصدر: | Journal of ethnopharmacology [J Ethnopharmacol] 2020 Oct 28; Vol. 261, pp. 113182. Date of Electronic Publication: 2020 Jul 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Sequoia Country of Publication: Ireland NLM ID: 7903310 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7573 (Electronic) Linking ISSN: 03788741 NLM ISO Abbreviation: J Ethnopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Limerick : Elsevier Sequoia Original Publication: Lausanne, Elsevier Sequoia. |
| مواضيع طبية MeSH: | Amaranthaceae/*chemistry , Aphrodisiacs/*pharmacology , Leydig Cells/*drug effects , Penis/*blood supply , Penis/*drug effects , Plant Extracts/*pharmacology, Amaranthaceae/toxicity ; Animals ; Aphrodisiacs/isolation & purification ; Aphrodisiacs/toxicity ; Cell Death/drug effects ; Estradiol/blood ; Fibrillar Collagens/metabolism ; Leydig Cells/metabolism ; Leydig Cells/pathology ; Male ; Mice ; Muscle, Smooth/drug effects ; Muscle, Smooth/pathology ; Nitric Oxide/metabolism ; Penis/metabolism ; Penis/pathology ; Plant Extracts/isolation & purification ; Plant Extracts/toxicity ; Plant Roots ; Solvents/chemistry ; Testosterone/blood ; Time Factors |
| مستخلص: | Ethnopharmacological Relevance: Roots of Pfaffia glomerata are used in traditional medicine as aphrodisiacs and sexual stimulants. Aim of the Study: The aim of this study was to evaluate the action of the hydroalcoholic extract from the roots of Pfaffia glomerata on the Leydig cells, cavernous bodies and other penile constituents, as well as on serum testosterone and 17β-estradiol levels of adult mice. Materials and Methods: Mature male Swiss mice were divided into 6 groups: control (water), sildenafil citrate, 3 groups receiving daily doses of P. glomerata extract (100, 200 and 400 mg/kg) and one group receiving intermittent doses of P. glomerata (200 mg/kg/3-3d). Results: The proportions of blood vessels, lymphatic space and estradiol levels were increased. On the other hand, reduction of testosterone levels due to Leydig cells death was observed. As for penile parameters, volumetric proportions of cavernous bodies, collagen and nitric oxide were increased, while smooth muscle content was decreased. Conclusions: Despite that the long term intake of P. glomerata extract was related to a stimulant action, reduction on Leydig cell viability induced decreased testosterone production. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Collagen; Estradiol; Leydig cells; Seminiferous tubule; Testosterone |
| المشرفين على المادة: | 0 (Aphrodisiacs) 0 (Fibrillar Collagens) 0 (Plant Extracts) 0 (Solvents) 31C4KY9ESH (Nitric Oxide) 3XMK78S47O (Testosterone) 4TI98Z838E (Estradiol) |
| تواريخ الأحداث: | Date Created: 20200731 Date Completed: 20210224 Latest Revision: 20210224 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.jep.2020.113182 |
| PMID: | 32730872 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-7573 |
|---|---|
| DOI: | 10.1016/j.jep.2020.113182 |