دورية أكاديمية
REM sleep stabilizes hypothalamic representation of feeding behavior.
| العنوان: | REM sleep stabilizes hypothalamic representation of feeding behavior. |
|---|---|
| المؤلفون: | Oesch LT; Zentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, CH-3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, CH-3010 Bern, Switzerland., Gazea M; Zentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, CH-3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, CH-3010 Bern, Switzerland., Gent TC; Zentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, CH-3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, CH-3010 Bern, Switzerland., Bandarabadi M; Zentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, CH-3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, CH-3010 Bern, Switzerland., Gutierrez Herrera C; Zentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, CH-3010 Bern, Switzerland.; Department of Biomedical Research, University of Bern, CH-3010 Bern, Switzerland., Adamantidis AR; Zentrum für Experimentelle Neurologie, Department of Neurology, Inselspital University Hospital Bern, CH-3010 Bern, Switzerland; antoine.adamantidis@dbmr.unibe.ch.; Department of Biomedical Research, University of Bern, CH-3010 Bern, Switzerland. |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2020 Aug 11; Vol. 117 (32), pp. 19590-19598. Date of Electronic Publication: 2020 Jul 30. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, DC : National Academy of Sciences |
| مواضيع طبية MeSH: | Feeding Behavior/*physiology , Hypothalamic Area, Lateral/*physiology , Sleep, REM/*physiology, Animals ; Brain Mapping ; Male ; Mice ; Nerve Net ; Neural Inhibition ; Neurons/metabolism ; Neurons/physiology ; Optogenetics ; Sleep/physiology ; Vesicular Inhibitory Amino Acid Transport Proteins/genetics ; Vesicular Inhibitory Amino Acid Transport Proteins/metabolism |
| مستخلص: | During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain-wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LH vgat ) show unique activity patterns during feeding that are reactivated during REM, but not non-REM, sleep. REM sleep-specific optogenetic silencing of LH vgat cells induced a reorganization of these activity patterns during subsequent feeding behaviors accompanied by decreased food intake. Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations of feeding behavior. Competing Interests: The authors declare no competing interest. (Copyright © 2020 the Author(s). Published by PNAS.) |
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| فهرسة مساهمة: | Keywords: REM sleep; calcium imaging; feeding; lateral hypothalamus; optogenetics |
| سلسلة جزيئية: | Dryad 10.5061/dryad.kh189323d |
| المشرفين على المادة: | 0 (Vesicular Inhibitory Amino Acid Transport Proteins) 0 (Viaat protein, mouse) |
| تواريخ الأحداث: | Date Created: 20200801 Date Completed: 20201001 Latest Revision: 20240329 |
| رمز التحديث: | 20240329 |
| مُعرف محوري في PubMed: | PMC7430996 |
| DOI: | 10.1073/pnas.1921909117 |
| PMID: | 32732431 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1091-6490 |
|---|---|
| DOI: | 10.1073/pnas.1921909117 |