دورية أكاديمية
أعرض في EDS

Parenteral fish oil: An adjuvant pharmacotherapy for coronavirus disease 2019?

التفاصيل البيبلوغرافية
العنوان: Parenteral fish oil: An adjuvant pharmacotherapy for coronavirus disease 2019?
المؤلفون: Torrinhas RS; Department of Gastroenterology, Faculty of Medicine, Laboratory of Nutrition and Metabolic Surgery, University of São Paulo, São Paulo, Brazil. Electronic address: rtorrinhas@gmail.com., Calder PC; Human Development & Health, Faculty of Medicine, University of Southampton, Southampton, United Kingdom; NIHR Southampton Biomedical Research Center, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, United Kingdom., Lemos GO; Department of Gastroenterology, Faculty of Medicine, Laboratory of Nutrition and Metabolic Surgery, University of São Paulo, São Paulo, Brazil., Waitzberg DL; Department of Gastroenterology, Faculty of Medicine, Laboratory of Nutrition and Metabolic Surgery, University of São Paulo, São Paulo, Brazil.
المصدر: Nutrition (Burbank, Los Angeles County, Calif.) [Nutrition] 2021 Jan; Vol. 81, pp. 110900. Date of Electronic Publication: 2020 Jun 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8802712 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1244 (Electronic) Linking ISSN: 08999007 NLM ISO Abbreviation: Nutrition Subsets: MEDLINE
أسماء مطبوعة: Publication: Tarrytown, NY : Elsevier Science
Original Publication: [Burbank, Calif. : Nutrition, c1987-
مواضيع طبية MeSH: COVID-19 Drug Treatment*, Fish Oils/*administration & dosage, COVID-19/epidemiology ; COVID-19/immunology ; Chemotherapy, Adjuvant ; Cytokine Release Syndrome/drug therapy ; Cytokine Release Syndrome/immunology ; Fatty Acids, Omega-3/administration & dosage ; Humans ; Inflammation/diet therapy ; Inflammation/immunology ; Infusions, Parenteral ; Models, Biological ; Nutritional Physiological Phenomena ; Pandemics ; SARS-CoV-2
مستخلص: The new coronavirus associated with severe acute respiratory syndrome (SARS-CoV-2), surprisingly, does not affect only the lungs. The severe response to SARS-CoV-2 appears to include a "cytokine storm," which indicates a state of hyperinflammation and subsequent dysfunction of multiple organs and tissues in the most severe cases. This could be the reason why populations at the highest risk for death from the SARS-CoV-2 infection-induced disease (coronavirus disease 2019 [COVID-19]) are those suffering from chronic low-grade inflammation, but prone to hyperinflammation. This includes individuals of advanced age and those with obesity, type 2 diabetes, hypertension, and metabolic syndrome. Inflammation resolution is strongly dependent on lipid mediators, the specialized pro-resolution mediators (SPMs). ω-3 polyunsaturated fatty acids (ω-3 PUFAs) are precursors of very potent SPMs, including resolvins, protectins, and maresins. Additionally, they are associated with a less aggressive inflammatory initiation, after competing with ω-6 fatty acids for eicosanoid synthesis. Therefore, it makes sense to consider the use of ω-3 PUFAs for clinical management of COVID-19 patients. ω-3 PUFAs may be given by oral, enteral, or parenteral routes; however, the parenteral route favors faster incorporation into plasma phospholipids, blood cells, and tissues. Here, we discuss these aspects to propose the parenteral infusion of ω-3 PUFAs as adjuvant immunopharmacotherapy for hospitalized patients with COVID-19.
Competing Interests: Declaration of Competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 Elsevier Inc. All rights reserved.)
التعليقات: Comment in: Nutrition. 2021 Feb;82:111052. (PMID: 33290970)
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فهرسة مساهمة: Keywords: COVID-19; Hyperinflammation; Parenteral fish oil; Resolution of inflammation; Specialized pro-resolving mediators
المشرفين على المادة: 0 (Fatty Acids, Omega-3)
0 (Fish Oils)
تواريخ الأحداث: Date Created: 20200802 Date Completed: 20201223 Latest Revision: 20221207
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC7836308
DOI: 10.1016/j.nut.2020.110900
PMID: 32738510
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1244
DOI:10.1016/j.nut.2020.110900