دورية أكاديمية
Zinc(II), copper(II) and nickel(II) ions improve the selectivity of tetra-cationic platinum(II) porphyrins in photodynamic therapy and stimulate antioxidant defenses in the metastatic melanoma lineage (A375).
| العنوان: | Zinc(II), copper(II) and nickel(II) ions improve the selectivity of tetra-cationic platinum(II) porphyrins in photodynamic therapy and stimulate antioxidant defenses in the metastatic melanoma lineage (A375). |
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| المؤلفون: | Klein Couto G; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: gaby_kc@yahoo.com.br., Rodrigues JC Junior; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: jcrodriguesjr@hotmail.com., Pacheco BS; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: pacheco.sbruna@gmail.com., Damé Simões L; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: lucasdame@hotmail.com., Paschoal JD; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: juliadfp@outlook.com., Seixas FK; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: seixas.fk@gmail.com., Acunha TV; Laboratory of Bioinorganic and Porphyrinoid Materials, Chemistry Department, Federal University of Santa Maria, Santa Maria, Brazil. Electronic address: thiagovacunha@hotmail.com., Iglesias BA; Laboratory of Bioinorganic and Porphyrinoid Materials, Chemistry Department, Federal University of Santa Maria, Santa Maria, Brazil. Electronic address: bernardopgq@gmail.com., Collares T; Molecular and Cellular Oncology Research Group, Cancer Biotechnology Laboratory, Technological Development Center, Federal University of Pelotas, Pelotas, Brazil. Electronic address: collares.t@gmail.com. |
| المصدر: | Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2020 Sep; Vol. 31, pp. 101942. Date of Electronic Publication: 2020 Aug 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101226123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1597 (Electronic) Linking ISSN: 15721000 NLM ISO Abbreviation: Photodiagnosis Photodyn Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; Boston : Elsevier, c2004- |
| مواضيع طبية MeSH: | Melanoma*/drug therapy , Photochemotherapy*/methods , Porphyrins*/pharmacology, Antioxidants/pharmacology ; Copper ; Humans ; Nickel ; Photosensitizing Agents/pharmacology ; Platinum ; Zinc |
| مستخلص: | Tetra-cationic porphyrins with peripheral Pt (II) -bipyridyl complexes demonstrated a potential as photosensitizers to be used in photodynamic therapy (PDT). First-line transition metals, such as zinc (II), copper (II) and nickel (II), can be incorporated into the porphyrin nucleus, making this molecule more selective and more effective for this therapy in combating to tumor cells, such as metastatic melanoma. We characterized these derivatives to verify the improvement in selectivity of platinum (II) 4-PtTPyP porphyrins. Receptors such as LDL and endothelin (ERT-B) were investigated, as well as the binding affinity of two antioxidants: catalase model enzymes and superoxide dismutase. Human serum albumin (SAH) HSA binding properties have been verified. In addition, we evaluated the antitumor action of such metalloporphyrins in an in vitro cell viability. Our results demonstrated that porphyrins have significant antitumor potential when exposed to white light conditions. The affinity for the LDL receptor was better when compared to platinum porphyrin 4-PtTPyP without addition of metals and the affinity for the endothelin receptor was higher than the control used in this study. Still, the interaction with the HSA showed the possibility of this connection taking photosensitizers to places of interest, such as the delivery of medicines. (Copyright © 2020 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cancer; Endothelin receptor (ERT-B); LDL receptor; Metalloporphyrins; Photodynamic Therapy |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Photosensitizing Agents) 0 (Porphyrins) 49DFR088MY (Platinum) 789U1901C5 (Copper) 7OV03QG267 (Nickel) J41CSQ7QDS (Zinc) |
| تواريخ الأحداث: | Date Created: 20200808 Date Completed: 20210514 Latest Revision: 20210514 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.pdpdt.2020.101942 |
| PMID: | 32758669 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1873-1597 |
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| DOI: | 10.1016/j.pdpdt.2020.101942 |