دورية أكاديمية
Fatal Outcome of Chikungunya Virus Infection in Brazil.
| العنوان: | Fatal Outcome of Chikungunya Virus Infection in Brazil. |
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| المؤلفون: | de Lima STS; Federal University of Ceará, Fortaleza, Brazil.; Central Public Health Laboratory of Ceará State, Fortaleza, Brazil., de Souza WM; Virology Research Center, University of São Paulo, Ribeirão Preto, Brazil., Cavalcante JW; Federal University of Ceará, Fortaleza, Brazil., da Silva Candido D; Department of Zoology, University of Oxford, Oxford, United Kingdom., Fumagalli MJ; Virology Research Center, University of São Paulo, Ribeirão Preto, Brazil., Carrera JP; Department of Zoology, University of Oxford, Oxford, United Kingdom.; Department of Research in Virology and Biotechnology, Gorgas Memorial Institute of Health Studies, Panama City, Panama., Simões Mello LM; Central Public Health Laboratory of Ceará State, Fortaleza, Brazil., De Carvalho Araújo FM; Central Public Health Laboratory of Ceará State, Fortaleza, Brazil.; Faculdade de Medicina do Centro Universitário Christus, Fortaleza, Ceará, Brazil., Cavalcante Ramalho IL; Central Public Health Laboratory of Ceará State, Fortaleza, Brazil., de Almeida Barreto FK; Federal University of Ceará, Fortaleza, Brazil., de Melo Braga DN; Death Verification Service Dr Rocha Furtado, State Health Secretariat of Ceará, Fortaleza, Ceará, Brazil., Simião AR; Federal University of Ceará, Fortaleza, Brazil., Miranda da Silva MJ; Evandro Chagas Institute, Ministry of Health, Ananindeua, Brazil., Alves Barbosa Oliveira RM; Federal University of Ceará, Fortaleza, Brazil., Lima CPS; Evandro Chagas Institute, Ministry of Health, Ananindeua, Brazil., de Sousa Lins C; Faculdade de Medicina do Centro Universitário Christus, Fortaleza, Ceará, Brazil., Barata RR; Evandro Chagas Institute, Ministry of Health, Ananindeua, Brazil., Pereira Melo MN; Faculdade de Medicina do Centro Universitário Christus, Fortaleza, Ceará, Brazil., Caldas de Souza MP; Evandro Chagas Institute, Ministry of Health, Ananindeua, Brazil., Franco LM; Faculdade de Medicina do Centro Universitário Christus, Fortaleza, Ceará, Brazil., Fernandes Távora FR; Faculdade de Medicina do Centro Universitário Christus, Fortaleza, Ceará, Brazil., Queiroz Lemos DR; Faculdade de Medicina do Centro Universitário Christus, Fortaleza, Ceará, Brazil., de Alencar CHM; Federal University of Ceará, Fortaleza, Brazil., de Jesus R; Universidade Federal de Minas Gerais, Brazil., de Souza Fonseca V; Universidade Federal de Minas Gerais, Brazil.; Ministry of Health, Brasilia, Brazil., Dutra LH; Ministry of Health, Brasilia, Brazil., de Abreu AL; Ministry of Health, Brasilia, Brazil., Lima Araújo EL; Ministry of Health, Brasilia, Brazil., Ribas Freitas AR; Faculdade de Medicina São Leopoldo Mandic, Campinas, São Paulo, Brazil., Vianez Júnior JLDSG; Evandro Chagas Institute, Ministry of Health, Ananindeua, Brazil., Pybus OG; Department of Zoology, University of Oxford, Oxford, United Kingdom., Figueiredo LTM; Virology Research Center, University of São Paulo, Ribeirão Preto, Brazil., Faria NR; Department of Zoology, University of Oxford, Oxford, United Kingdom.; Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom., Nunes MRT; Evandro Chagas Institute, Ministry of Health, Ananindeua, Brazil., Cavalcanti LPG; Federal University of Ceará, Fortaleza, Brazil., Miyajima F; Federal University of Ceará, Fortaleza, Brazil.; Oswaldo Cruz Foundation (Fiocruz), Branch Ceará, Eusebio, Brazil. |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2021 Oct 05; Vol. 73 (7), pp. e2436-e2443. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Oxford : Oxford University Press Original Publication: Chicago, IL : The University of Chicago Press, c1992- |
| مواضيع طبية MeSH: | Chikungunya Fever*/epidemiology , Dengue* , Dengue Virus* , Zika Virus*/genetics , Zika Virus Infection*/epidemiology, Brazil/epidemiology ; Cross-Sectional Studies ; Humans ; Phylogeny ; Retrospective Studies ; Young Adult |
| مستخلص: | Background: Chikungunya virus (CHIKV) emerged in the Americas in 2013 and has caused approximately 2.1 million cases and >600 deaths. A retrospective investigation was undertaken to describe clinical, epidemiological, and viral genomic features associated with deaths caused by CHIKV in Ceará state, northeast Brazil. Methods: Sera, cerebrospinal fluid (CSF), and tissue samples from 100 fatal cases with suspected arbovirus infection were tested for CHIKV, dengue virus (DENV), and Zika virus (ZIKV). Clinical, epidemiological, and death reports were obtained for patients with confirmed CHIKV infection. Logistic regression analysis was undertaken to identify independent factors associated with risk of death during CHIKV infection. Phylogenetic analysis was conducted using whole genomes from a subset of cases. Results: Sixty-eight fatal cases had CHIKV infection confirmed by reverse-transcription quantitative polymerase chain reaction (52.9%), viral antigen (41.1%), and/or specific immunoglobulin M (63.2%). Co-detection of CHIKV with DENV was found in 22% of fatal cases, ZIKV in 2.9%, and DENV and ZIKV in 1.5%. A total of 39 CHIKV deaths presented with neurological signs and symptoms, and CHIKV-RNA was found in the CSF of 92.3% of these patients. Fatal outcomes were associated with irreversible multiple organ dysfunction syndrome. Patients with diabetes appear to die at a higher frequency during the subacute phase. Genetic analysis showed circulation of 2 CHIKV East-Central-South African (ECSA) lineages in Ceará and revealed no unique virus genomic mutation associated with fatal outcome. Conclusions: The investigation of the largest cross-sectional cohort of CHIKV deaths to date reveals that CHIKV-ECSA strains can cause death in individuals from both risk and nonrisk groups, including young adults. (© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.) |
| معلومات مُعتمدة: | 302584/2015-3 Brazilian National Council for Scientific and Technological Development; MR/S019510/1 United Kingdom MRC_ Medical Research Council; 204311/Z/16/Z Wellcome Trust and Royal Society Sir Henry Dale Fellowship; Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico; 408338/2018-0 Brazilian National Council for Scientific and Technological Development; 2017/13981-0 São Paulo Research Foundation; United Kingdom WT_ Wellcome Trust; MR/R015600/1 United Kingdom MRC_ Medical Research Council |
| فهرسة مساهمة: | Keywords: Alphavirus; arthritogenic; arbovirus; chikungunya virus; fatal cases |
| تواريخ الأحداث: | Date Created: 20200809 Date Completed: 20211020 Latest Revision: 20220211 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8492446 |
| DOI: | 10.1093/cid/ciaa1038 |
| PMID: | 32766829 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1537-6591 |
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| DOI: | 10.1093/cid/ciaa1038 |