دورية أكاديمية
أعرض في EDS

Water-soluble tetra-cationic porphyrins display virucidal activity against Bovine adenovirus and Bovine alphaherpesvirus 1.

التفاصيل البيبلوغرافية
العنوان: Water-soluble tetra-cationic porphyrins display virucidal activity against Bovine adenovirus and Bovine alphaherpesvirus 1.
المؤلفون: Ries AS; Programa de Residência em Área Profissional da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil; Programa de Pós-graduação em Medicina Veterinária, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil., Cargnelutti JF; Departamento de Medicina Veterinária Preventiva (DMVP), Centro de Ciências Rurais (CCR), UFSM, Santa Maria, RS, Brazil., Basso G; Programa de Pós-graduação em Medicina Veterinária, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil., Acunha TV; Laboratório de Bioinorgânica e Materiais Porfirínicos, Departamento de Química, Centro de Ciências Naturais e Exatas (CCNE), UFSM, Santa Maria, RS, Brazil., Iglesias BA; Laboratório de Bioinorgânica e Materiais Porfirínicos, Departamento de Química, Centro de Ciências Naturais e Exatas (CCNE), UFSM, Santa Maria, RS, Brazil. Electronic address: bernardopgq@gmail.com., Flores EF; Departamento de Medicina Veterinária Preventiva (DMVP), Centro de Ciências Rurais (CCR), UFSM, Santa Maria, RS, Brazil. Electronic address: eduardofurtadoflores@gmail.com., Weiblen R; Departamento de Medicina Veterinária Preventiva (DMVP), Centro de Ciências Rurais (CCR), UFSM, Santa Maria, RS, Brazil.
المصدر: Photodiagnosis and photodynamic therapy [Photodiagnosis Photodyn Ther] 2020 Sep; Vol. 31, pp. 101947. Date of Electronic Publication: 2020 Aug 06.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101226123 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-1597 (Electronic) Linking ISSN: 15721000 NLM ISO Abbreviation: Photodiagnosis Photodyn Ther Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam ; Boston : Elsevier, c2004-
مواضيع طبية MeSH: Photochemotherapy*/methods , Porphyrins*/pharmacology, Adenoviridae ; Animals ; Cattle ; Photosensitizing Agents/pharmacology ; Water
مستخلص: Porphyrins are photoactive compounds that can absorb the energy of light and transfer it to oxygen molecules, producing reactive oxygen species (ROS). Once produced, ROS may alter biological molecules and cellular mechanisms, leading to cell apoptosis or inactivation of microorganisms, such as bacteria, fungi, and viruses. Therefore, the objective of this study was to evaluate the in vitro virucidal activity of six tetra-cationic porphyrins against two bovine viruses (Bovine alphaherpesvirus 1, BoHV-1, enveloped; and Bovine adenovirus, BAV, non-enveloped). For this, viral suspensions were incubated with each porphyrin (H 2 TMeP, ZnTMeP, and CuTMeP at 4.0 μM, NiTMeP at 5.0 μM, and CoClTMeP and MnClTMeP at 1.0 μM) and exposed to white-light irradiation for 0, 60, 120, and 180 min (BAV) or 0, 30, 60, 90, and 120 min (BoHV-1). Then, the remaining viral titers were determined by limiting dilution and compared with the control (virus + porphyrins without light exposition). The porphyrins H 2 TMeP and ZnTMeP showed the highest virucidal activity against both viruses. ZnTMeP inactivated BoHV-1 after 30 min of photoactivation and H 2 TMeP after 60 min. The BAV was photo-inactivated by both porphyrins at 180 min of white-light exposition. CuTMeP, NiTMeP, and CoClTMeP porphyrins had weak virucidal activity against BoHV-1 and MnClTMeP showed no virucidal activity against both viruses. These results indicated that free-base H 2 TMeP and ZnTMeP porphyrins present virucidal activity against non-enveloped and enveloped viruses, opening the possibility for their use to inactivate viruses on surfaces, biological substrates, and solutions.
(Copyright © 2020 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: cationic porphyrins; virus photo-inactivation; water-soluble porphyrins
المشرفين على المادة: 0 (Photosensitizing Agents)
0 (Porphyrins)
059QF0KO0R (Water)
تواريخ الأحداث: Date Created: 20200810 Date Completed: 20210514 Latest Revision: 20210514
رمز التحديث: 20221213
DOI: 10.1016/j.pdpdt.2020.101947
PMID: 32768587
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-1597
DOI:10.1016/j.pdpdt.2020.101947