دورية أكاديمية
Timing and delay of radical prostatectomy do not lead to adverse oncologic outcomes: results from a large European cohort at the times of COVID-19 pandemic.
| العنوان: | Timing and delay of radical prostatectomy do not lead to adverse oncologic outcomes: results from a large European cohort at the times of COVID-19 pandemic. |
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| المؤلفون: | Diamand R; Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. romain.diamand@erasme.ulb.ac.be., Ploussard G; Urology Department, La Croix du Sud Hospital, Quint Fonsegrives, France., Roumiguié M; Urology Department, CHU Toulouse, Toulouse, France., Oderda M; Urology Department, Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Benamran D; Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland., Fiard G; Urology Department, CHU de Grenoble, Grenoble, France.; Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France., Peltier A; Urology Department, Jules Bordet Institute, Brussels, Belgium., Simone G; Urology Department, IRCCS 'Regina Elena' National Cancer Institute, Rome, Italy., Van Damme J; Urology Department, University Clinics Saint-Luc, Université Catholique de Louvain, Brussels, Belgium., Malavaud B; Urology Department, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse, France., Iselin C; Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland., Descotes JL; Urology Department, CHU de Grenoble, Grenoble, France.; Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France., Roche JB; Urology Department, Clinique Saint-Augustin, Bordeaux, France., Quackels T; Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium., Roumeguère T; Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium., Albisinni S; Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. |
| المصدر: | World journal of urology [World J Urol] 2021 Jun; Vol. 39 (6), pp. 1789-1796. Date of Electronic Publication: 2020 Aug 10. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8307716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-8726 (Electronic) Linking ISSN: 07244983 NLM ISO Abbreviation: World J Urol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Berlin ; New York] : Springer International, 1983- |
| مواضيع طبية MeSH: | COVID-19*/epidemiology , COVID-19*/prevention & control , Oncology Service, Hospital*/statistics & numerical data , Oncology Service, Hospital*/trends , Prostatectomy*/methods , Prostatectomy*/statistics & numerical data , Prostatic Neoplasms*/epidemiology , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/surgery , Time-to-Treatment*/standards , Time-to-Treatment*/statistics & numerical data, Aged ; Europe/epidemiology ; Humans ; Infection Control/methods ; Kaplan-Meier Estimate ; Male ; Neoplasm Grading ; Neoplasm Staging ; Organizational Innovation ; Outcome Assessment, Health Care ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; SARS-CoV-2 |
| مستخلص: | Purpose: The current COVID-19 pandemic is transforming our urologic practice and most urologic societies recommend to defer any surgical treatment for prostate cancer (PCa) patients. It is unclear whether a delay between diagnosis and surgical management (i.e., surgical delay) may have a detrimental effect on oncologic outcomes of PCa patients. The aim of the study was to assess the impact of surgical delay on oncologic outcomes. Methods: Data of 926 men undergoing radical prostatectomy across Europe for intermediate and high-risk PCa according to EAU classification were identified. Multivariable analysis using binary logistic regression and Cox proportional hazard model tested association between surgical delay and upgrading on final pathology, lymph-node invasion (LNI), pathological locally advanced disease (pT3-4 and/or pN1), need for adjuvant therapy, and biochemical recurrence. Kaplan-Meier analysis was used to estimate BCR-free survival after surgery as a function of surgical delay using a 3 month cut-off. Results: Median follow-up and surgical delay were 26 months (IQR 10-40) and 3 months (IQR 2-5), respectively. We did not find any significant association between surgical delay and oncologic outcomes when adjusted to pre- and post-operative variables. The lack of such association was observed across EAU risk categories. Conclusion: Delay of several months did not appear to adversely impact oncologic results for intermediate and high-risk PCa, and support an attitude of deferring surgery in line with the current recommendation of urologic societies. |
| References: | Cancer. 2013 Jan 15;119(2):421-8. (PMID: 22786794) Eur Urol. 2020 Jun;77(6):663-666. (PMID: 32279903) BJU Int. 2020 Jun;125(6):E7-E14. (PMID: 32249538) Prog Urol. 2018 Sep;28(10):475-481. (PMID: 29907495) Urol Oncol. 2017 Apr;35(4):150.e9-150.e15. (PMID: 27986374) BJU Int. 2019 Aug;124(2):268-274. (PMID: 30570825) Eur Urol. 2016 Aug;70(2):211-3. (PMID: 26553331) Scand J Urol. 2016 Aug;50(4):246-54. (PMID: 27067998) World J Urol. 2019 Oct;37(10):2109-2117. (PMID: 30652213) World J Urol. 2018 Jan;36(1):1-6. (PMID: 29052761) Eur Urol. 2017 Apr;71(4):618-629. (PMID: 27568654) Urol Oncol. 2003 Mar-Apr;21(2):93-100. (PMID: 12856636) J Magn Reson Imaging. 2019 Jun;49(7):e65-e77. (PMID: 30637891) Clin Genitourin Cancer. 2006 Dec;5(3):219-26. (PMID: 17239276) Eur Urol. 2020 Jul;78(1):21-28. (PMID: 32376137) Eur Urol. 2013 Aug;64(2):204-15. (PMID: 23453419) Int Braz J Urol. 2019 May-Jun;45(3):468-477. (PMID: 30676305) J Urol. 2020 Oct;204(4):720-725. (PMID: 32356508) |
| فهرسة مساهمة: | Keywords: Biochemical recurrence; COVID-19; Delay; Oncologic outcomes; Prostate cancer |
| تواريخ الأحداث: | Date Created: 20200811 Date Completed: 20210629 Latest Revision: 20220716 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC7416303 |
| DOI: | 10.1007/s00345-020-03402-w |
| PMID: | 32776243 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1433-8726 |
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| DOI: | 10.1007/s00345-020-03402-w |