دورية أكاديمية
Timing and delay of radical prostatectomy do not lead to adverse oncologic outcomes: results from a large European cohort at the times of COVID-19 pandemic.
العنوان: | Timing and delay of radical prostatectomy do not lead to adverse oncologic outcomes: results from a large European cohort at the times of COVID-19 pandemic. |
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المؤلفون: | Diamand R; Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. romain.diamand@erasme.ulb.ac.be., Ploussard G; Urology Department, La Croix du Sud Hospital, Quint Fonsegrives, France., Roumiguié M; Urology Department, CHU Toulouse, Toulouse, France., Oderda M; Urology Department, Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy., Benamran D; Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland., Fiard G; Urology Department, CHU de Grenoble, Grenoble, France.; Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France., Peltier A; Urology Department, Jules Bordet Institute, Brussels, Belgium., Simone G; Urology Department, IRCCS 'Regina Elena' National Cancer Institute, Rome, Italy., Van Damme J; Urology Department, University Clinics Saint-Luc, Université Catholique de Louvain, Brussels, Belgium., Malavaud B; Urology Department, Institut Universitaire du Cancer Toulouse-Oncopole, Toulouse, France., Iselin C; Urology Department, Hôpitaux Universitaires de Genève, Geneva, Switzerland., Descotes JL; Urology Department, CHU de Grenoble, Grenoble, France.; Grenoble Alpes University, CNRS, Grenoble INP, TIMC-IMAG, Grenoble, France., Roche JB; Urology Department, Clinique Saint-Augustin, Bordeaux, France., Quackels T; Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium., Roumeguère T; Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium., Albisinni S; Urology Department, Hôpital Erasme, University Clinics of Brussels, Université Libre de Bruxelles, Route de Lennik 808, 1070, Brussels, Belgium. |
المصدر: | World journal of urology [World J Urol] 2021 Jun; Vol. 39 (6), pp. 1789-1796. Date of Electronic Publication: 2020 Aug 10. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer International Country of Publication: Germany NLM ID: 8307716 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1433-8726 (Electronic) Linking ISSN: 07244983 NLM ISO Abbreviation: World J Urol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [Berlin ; New York] : Springer International, 1983- |
مواضيع طبية MeSH: | COVID-19*/epidemiology , COVID-19*/prevention & control , Oncology Service, Hospital*/statistics & numerical data , Oncology Service, Hospital*/trends , Prostatectomy*/methods , Prostatectomy*/statistics & numerical data , Prostatic Neoplasms*/epidemiology , Prostatic Neoplasms*/pathology , Prostatic Neoplasms*/surgery , Time-to-Treatment*/standards , Time-to-Treatment*/statistics & numerical data, Aged ; Europe/epidemiology ; Humans ; Infection Control/methods ; Kaplan-Meier Estimate ; Male ; Neoplasm Grading ; Neoplasm Staging ; Organizational Innovation ; Outcome Assessment, Health Care ; Risk Assessment/methods ; Risk Assessment/statistics & numerical data ; SARS-CoV-2 |
مستخلص: | Purpose: The current COVID-19 pandemic is transforming our urologic practice and most urologic societies recommend to defer any surgical treatment for prostate cancer (PCa) patients. It is unclear whether a delay between diagnosis and surgical management (i.e., surgical delay) may have a detrimental effect on oncologic outcomes of PCa patients. The aim of the study was to assess the impact of surgical delay on oncologic outcomes. Methods: Data of 926 men undergoing radical prostatectomy across Europe for intermediate and high-risk PCa according to EAU classification were identified. Multivariable analysis using binary logistic regression and Cox proportional hazard model tested association between surgical delay and upgrading on final pathology, lymph-node invasion (LNI), pathological locally advanced disease (pT3-4 and/or pN1), need for adjuvant therapy, and biochemical recurrence. Kaplan-Meier analysis was used to estimate BCR-free survival after surgery as a function of surgical delay using a 3 month cut-off. Results: Median follow-up and surgical delay were 26 months (IQR 10-40) and 3 months (IQR 2-5), respectively. We did not find any significant association between surgical delay and oncologic outcomes when adjusted to pre- and post-operative variables. The lack of such association was observed across EAU risk categories. Conclusion: Delay of several months did not appear to adversely impact oncologic results for intermediate and high-risk PCa, and support an attitude of deferring surgery in line with the current recommendation of urologic societies. |
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فهرسة مساهمة: | Keywords: Biochemical recurrence; COVID-19; Delay; Oncologic outcomes; Prostate cancer |
تواريخ الأحداث: | Date Created: 20200811 Date Completed: 20210629 Latest Revision: 20220716 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC7416303 |
DOI: | 10.1007/s00345-020-03402-w |
PMID: | 32776243 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1433-8726 |
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DOI: | 10.1007/s00345-020-03402-w |