دورية أكاديمية
أعرض في EDS

Generation of three Duchenne muscular dystrophy patient-derived induced pluripotent stem cell (iPSC) lines ICGi002-A, ICGi002-B and ICGi002-C.

التفاصيل البيبلوغرافية
العنوان: Generation of three Duchenne muscular dystrophy patient-derived induced pluripotent stem cell (iPSC) lines ICGi002-A, ICGi002-B and ICGi002-C.
المؤلفون: Valetdinova KR; Federal Research Center Institute of Cytology and Genetics, Novosibirsk, Russia; E.N. Meshalkin National Medical Research Centre, Ministry of Healthcare of Russian Federation, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia. Electronic address: valetdinova@bionet.nsc.ru., Maretina MA; D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia., Vyatkin YV; Federal Research Center Institute of Cytology and Genetics, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia; AcademGene LLC, Novosibirsk, Russia., Perepelkina MP; JSC BIOCAD, Saint Petersburg, Russia., Egorova AA; D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia., Baranov VS; D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia., Kiselev AV; D.O. Ott Research Institute of Obstetrics, Gynecology and Reproductology, Saint Petersburg, Russia., Gershovich PM; JSC BIOCAD, Saint Petersburg, Russia; Saint Petersburg State Chemical Pharmaceutical University, Saint Petersburg, Russia., Zakian SM; Federal Research Center Institute of Cytology and Genetics, Novosibirsk, Russia; Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia; E.N. Meshalkin National Medical Research Centre, Ministry of Healthcare of Russian Federation, Novosibirsk, Russia; Novosibirsk State University, Novosibirsk, Russia.
المصدر: Stem cell research [Stem Cell Res] 2020 Oct; Vol. 48, pp. 101941. Date of Electronic Publication: 2020 Aug 03.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101316957 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-7753 (Electronic) Linking ISSN: 18735061 NLM ISO Abbreviation: Stem Cell Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Kidlington, Oxford : Elsevier
مواضيع طبية MeSH: Induced Pluripotent Stem Cells* , Muscular Dystrophy, Duchenne*/genetics, Cell Differentiation ; Dystrophin/genetics ; Humans ; Male
مستخلص: Duchenne muscular dystrophy (DMD) is a severe and rapidly progressive hereditary muscular disease with X-linked recessive inheritance, occurring mainly in males. A complete loss of dystrophin resulted from out-of-frame deletion mutations in the DMD gene leads to Duchenne muscular dystrophy. DMD induced pluripotent stem cells (iPSCs) are a suitable cell model to study muscle development and disease mechanisms underlying muscular dystrophy and to screen novel compounds with potential therapeutic effects. We generated iPSCs from a DMD patient using non-integrating episomal plasmid vectors. The obtained iPSC lines showed ESC-like morphology, expression pluripotency markers, displayed a normal karyotype and possessed trilineage differentiation potential.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.)
المشرفين على المادة: 0 (Dystrophin)
تواريخ الأحداث: Date Created: 20200811 Date Completed: 20210621 Latest Revision: 20210621
رمز التحديث: 20221213
DOI: 10.1016/j.scr.2020.101941
PMID: 32777771
قاعدة البيانات: MEDLINE
الوصف
تدمد:1876-7753
DOI:10.1016/j.scr.2020.101941