دورية أكاديمية
أعرض في EDS

Involvement of WNT2 in trophoblast cell behavior in preeclampsia development.

التفاصيل البيبلوغرافية
العنوان: Involvement of WNT2 in trophoblast cell behavior in preeclampsia development.
المؤلفون: Liu Y; Department of Obstetrics and Gynecology, Binzhou Medical University Hospital , Binzhou City, Shandong Province, China., Huang J; Department of Obstetrics and Gynecology, Binzhou Medical University Hospital , Binzhou City, Shandong Province, China., Yu N; Department of Pathology, Binzhou Medical University Hospital , Binzhou City, Shandong Province, China., Wei S; Department of Obstetrics and Gynecology, Binzhou Medical University Hospital , Binzhou City, Shandong Province, China., Liu Z; Department of Obstetrics and Gynecology, Binzhou Medical University Hospital , Binzhou City, Shandong Province, China.
المصدر: Cell cycle (Georgetown, Tex.) [Cell Cycle] 2020 Sep; Vol. 19 (17), pp. 2207-2215. Date of Electronic Publication: 2020 Aug 11.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137841 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1551-4005 (Electronic) Linking ISSN: 15514005 NLM ISO Abbreviation: Cell Cycle Subsets: MEDLINE
أسماء مطبوعة: Publication: 2015- : Philadelphia, PA : Taylor & Francis
Original Publication: Georgetown, TX : Landes Bioscience, c2002-
مواضيع طبية MeSH: Pre-Eclampsia/*metabolism , Pre-Eclampsia/*pathology , Trophoblasts/*metabolism , Trophoblasts/*pathology , Wnt2 Protein/*metabolism, Cell Line ; Cell Movement/genetics ; Female ; Gene Knockdown Techniques ; Humans ; Pregnancy ; Wnt2 Protein/genetics ; beta Catenin/genetics ; beta Catenin/metabolism
مستخلص: This study aimed to determine the WNT2 expression in patients with severe preeclampsia and to explore the function of WNT2 dysregulation on the biological behaviors of trophoblast cells. The WNT2 and β-catenin expression in the patients with early-onset and late-onset severe preeclampsia and normal controls was determined. Subsequently, WNT2 was overexpressed and knocked down in HTR8 cells and WNT2 signaling pathway in regulating trophoblast cell proliferation, migration, invasion, and apoptosis were evaluated in vitro . The mRNA and protein expression levels of WNT2 and β-catenin were decreased in patients with preeclampsia, especially early-onset severe preeclampsia. Overexpression of WNT2 promoted trophoblast cell proliferation, migration, and invasion and inhibited apoptosis in vitro , whereas knockdown of WNT2 had opposite effects. The findings of this study reveal that WNT2 and β-catenin were decreased expressed in patients with preeclampsia. Decreased expression of WNT2 may inhibit trophoblast cell proliferation, migration, and invasion but induced apoptosis. WNT2 may serve as a promising biomarker for early detection of preeclampsia.
References: Oncol Lett. 2018 Sep;16(3):2857-2864. (PMID: 30127872)
J Mol Histol. 2018 Jun;49(3):317-327. (PMID: 29603045)
Mol Med Rep. 2017 Aug;16(2):1007-1013. (PMID: 29067442)
Med Oncol. 2015 Apr;32(4):97. (PMID: 25731618)
Cell Adh Migr. 2018 May 4;12(3):259-270. (PMID: 29231798)
J Matern Fetal Neonatal Med. 2018 Mar;31(6):817-821. (PMID: 28282763)
J Matern Fetal Neonatal Med. 2017 Dec;30(23):2789-2794. (PMID: 28282780)
Angiogenesis. 2020 May;23(2):159-177. (PMID: 31667643)
Clin Exp Obstet Gynecol. 2011;38(1):38-42. (PMID: 21485723)
Nat Rev Nephrol. 2019 May;15(5):275-289. (PMID: 30792480)
Mediators Inflamm. 2018 Mar 15;2018:9787239. (PMID: 29736154)
Clin Exp Obstet Gynecol. 2013;40(1):45-8. (PMID: 23724505)
Am J Obstet Gynecol. 2017 Aug;217(2):200.e1-200.e17. (PMID: 28347715)
J Matern Fetal Neonatal Med. 2017 Jun;30(11):1335-1341. (PMID: 27500318)
Clin Chim Acta. 2019 Mar;490:154-160. (PMID: 30594543)
Clin J Am Soc Nephrol. 2016 Jun 6;11(6):1102-1113. (PMID: 27094609)
Oncogene. 2017 Sep 28;36(39):5460-5472. (PMID: 28553956)
Med Sci Monit. 2017 Nov 07;23:5294-5301. (PMID: 29109390)
J Clin Endocrinol Metab. 2015 Jan;100(1):E19-29. (PMID: 25313909)
Oncogene. 2017 Mar;36(11):1461-1473. (PMID: 27617575)
Semin Nephrol. 2017 Jul;37(4):386-397. (PMID: 28711078)
Arch Gynecol Obstet. 2019 Jun;299(6):1551-1556. (PMID: 30905002)
Int J Biochem Cell Biol. 2018 Dec;105:35-40. (PMID: 30266525)
Am J Cancer Res. 2015 Feb 15;5(3):1032-46. (PMID: 26045984)
Placenta. 2015 Jun;36(6):645-51. (PMID: 25904157)
Int J Clin Exp Med. 2015 Sep 15;8(9):16301-7. (PMID: 26629148)
فهرسة مساهمة: Keywords: Preeclampsia; WNT2; apoptosis; invasion; migration
المشرفين على المادة: 0 (Wnt2 Protein)
0 (beta Catenin)
تواريخ الأحداث: Date Created: 20200812 Date Completed: 20210901 Latest Revision: 20231112
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7513852
DOI: 10.1080/15384101.2020.1802913
PMID: 32779546
قاعدة البيانات: MEDLINE
الوصف
تدمد:1551-4005
DOI:10.1080/15384101.2020.1802913