دورية أكاديمية
Involvement of WNT2 in trophoblast cell behavior in preeclampsia development.
العنوان: | Involvement of WNT2 in trophoblast cell behavior in preeclampsia development. |
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المؤلفون: | Liu Y; Department of Obstetrics and Gynecology, Binzhou Medical University Hospital , Binzhou City, Shandong Province, China., Huang J; Department of Obstetrics and Gynecology, Binzhou Medical University Hospital , Binzhou City, Shandong Province, China., Yu N; Department of Pathology, Binzhou Medical University Hospital , Binzhou City, Shandong Province, China., Wei S; Department of Obstetrics and Gynecology, Binzhou Medical University Hospital , Binzhou City, Shandong Province, China., Liu Z; Department of Obstetrics and Gynecology, Binzhou Medical University Hospital , Binzhou City, Shandong Province, China. |
المصدر: | Cell cycle (Georgetown, Tex.) [Cell Cycle] 2020 Sep; Vol. 19 (17), pp. 2207-2215. Date of Electronic Publication: 2020 Aug 11. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137841 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1551-4005 (Electronic) Linking ISSN: 15514005 NLM ISO Abbreviation: Cell Cycle Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2015- : Philadelphia, PA : Taylor & Francis Original Publication: Georgetown, TX : Landes Bioscience, c2002- |
مواضيع طبية MeSH: | Pre-Eclampsia/*metabolism , Pre-Eclampsia/*pathology , Trophoblasts/*metabolism , Trophoblasts/*pathology , Wnt2 Protein/*metabolism, Cell Line ; Cell Movement/genetics ; Female ; Gene Knockdown Techniques ; Humans ; Pregnancy ; Wnt2 Protein/genetics ; beta Catenin/genetics ; beta Catenin/metabolism |
مستخلص: | This study aimed to determine the WNT2 expression in patients with severe preeclampsia and to explore the function of WNT2 dysregulation on the biological behaviors of trophoblast cells. The WNT2 and β-catenin expression in the patients with early-onset and late-onset severe preeclampsia and normal controls was determined. Subsequently, WNT2 was overexpressed and knocked down in HTR8 cells and WNT2 signaling pathway in regulating trophoblast cell proliferation, migration, invasion, and apoptosis were evaluated in vitro . The mRNA and protein expression levels of WNT2 and β-catenin were decreased in patients with preeclampsia, especially early-onset severe preeclampsia. Overexpression of WNT2 promoted trophoblast cell proliferation, migration, and invasion and inhibited apoptosis in vitro , whereas knockdown of WNT2 had opposite effects. The findings of this study reveal that WNT2 and β-catenin were decreased expressed in patients with preeclampsia. Decreased expression of WNT2 may inhibit trophoblast cell proliferation, migration, and invasion but induced apoptosis. WNT2 may serve as a promising biomarker for early detection of preeclampsia. |
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فهرسة مساهمة: | Keywords: Preeclampsia; WNT2; apoptosis; invasion; migration |
المشرفين على المادة: | 0 (Wnt2 Protein) 0 (beta Catenin) |
تواريخ الأحداث: | Date Created: 20200812 Date Completed: 20210901 Latest Revision: 20231112 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC7513852 |
DOI: | 10.1080/15384101.2020.1802913 |
PMID: | 32779546 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1551-4005 |
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DOI: | 10.1080/15384101.2020.1802913 |