دورية أكاديمية
أعرض في EDS

Malaria in pregnancy regulates P-glycoprotein (P-gp/Abcb1a) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac.

التفاصيل البيبلوغرافية
العنوان: Malaria in pregnancy regulates P-glycoprotein (P-gp/Abcb1a) and ABCA1 efflux transporters in the Mouse Visceral Yolk Sac.
المؤلفون: Martinelli LM; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Fontes KN; Laboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Reginatto MW; Laboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Andrade CBV; Laboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Monteiro VRS; Laboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Gomes HR; Laboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Silva-Filho JL; Laboratory of Immunology and Biochemistry of Parasitic Diseases, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Pinheiro AAS; Laboratory of Immunology and Biochemistry of Parasitic Diseases, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Vago AR; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Almeida FRCL; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil., Bloise FF; Laboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Matthews SG; Department of Physiology, University of Toronto, Toronto, ON, Canada.; Department of Obstetrics and Gynecology, University of Toronto, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada., Ortiga-Carvalho TM; Laboratory of Translational Endocrinology, Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Bloise E; Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
المصدر: Journal of cellular and molecular medicine [J Cell Mol Med] 2020 Sep; Vol. 24 (18), pp. 10636-10647. Date of Electronic Publication: 2020 Aug 11.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, England : Wiley-Blackwell
Original Publication: Bucharest : "Carol Davila" University Press, 2000-
مواضيع طبية MeSH: Gene Expression Regulation*, ATP Binding Cassette Transporter 1/*biosynthesis , ATP Binding Cassette Transporter, Subfamily B/*biosynthesis , Malaria/*metabolism , Pregnancy Complications, Infectious/*metabolism , Yolk Sac/*metabolism, ATP Binding Cassette Transporter 1/genetics ; ATP Binding Cassette Transporter, Subfamily B/genetics ; Animals ; Biological Transport ; Cytokines/biosynthesis ; Cytokines/genetics ; Female ; Fetal Growth Retardation/etiology ; Inflammation ; Malaria/complications ; Malaria/genetics ; Membrane Transport Proteins/biosynthesis ; Membrane Transport Proteins/genetics ; Mice ; Mice, Inbred C57BL ; Organ Size ; Plasmodium berghei ; Pregnancy ; Pregnancy Complications, Infectious/genetics ; RNA, Messenger/biosynthesis ; RNA, Messenger/genetics ; Yolk Sac/ultrastructure
مستخلص: Malaria in pregnancy (MiP) induces intrauterine growth restriction (IUGR) and preterm labour (PTL). However, its effects on yolk sac morphology and function are largely unexplored. We hypothesized that MiP modifies yolk sac morphology and efflux transport potential by modulating ABC efflux transporters. C57BL/6 mice injected with Plasmodium berghei ANKA (5 × 10 5 infected erythrocytes) at gestational day (GD) 13.5 were subjected to yolk sac membrane harvesting at GD 18.5 for histology, qPCR and immunohistochemistry. MiP did not alter the volumetric proportion of the yolk sac's histological components. However, it increased levels of Abcb1a mRNA (encoding P-glycoprotein) and macrophage migration inhibitory factor (Mif chemokine), while decreasing Abcg1 (P < 0.05); without altering Abca1, Abcb1b, Abcg2, Snat1, Snat2, interleukin (Il)-1β and C-C Motif chemokine ligand 2 (Ccl2). Transcripts of Il-6, chemokine (C-X-C motif) ligand 1 (Cxcl1), Glut1 and Snat4 were not detectible. ABCA1, ABCG1, breast cancer resistance protein (BCRP) and P-gp were primarily immunolocalized to the cell membranes and cytoplasm of endodermic epithelium but also in the mesothelium and in the endothelium of mesodermic blood vessels. Intensity of P-gp labelling was stronger in both endodermic epithelium and mesothelium, whereas ABCA1 labelling increased in the endothelium of the mesodermic blood vessels. The presence of ABC transporters in the yolk sac wall suggests that this fetal membrane acts as an important protective gestational barrier. Changes in ABCA1 and P-gp in MiP may alter the biodistribution of toxic substances, xenobiotics, nutrients and immunological factors within the fetal compartment and participate in the pathogenesis of malaria-induced IUGR and PTL.
(© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
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معلومات مُعتمدة: OPP1107597 United States GATES Bill & Melinda Gates Foundation; Foundation-148368 Canada CIHR
فهرسة مساهمة: Keywords: Plasmodium berghei ANKA; ABCA1; ABCG1; Breast Cancer Resistance Protein (BCRP); P-glycoprotein (P-gp); malaria in pregnancy (MiP); yolk sac
المشرفين على المادة: 0 (ABCA1 protein, mouse)
0 (ATP Binding Cassette Transporter 1)
0 (ATP Binding Cassette Transporter, Subfamily B)
0 (Cytokines)
0 (Membrane Transport Proteins)
0 (RNA, Messenger)
9EI49ZU76O (multidrug resistance protein 3)
تواريخ الأحداث: Date Created: 20200812 Date Completed: 20210512 Latest Revision: 20210512
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC7521277
DOI: 10.1111/jcmm.15682
PMID: 32779889
قاعدة البيانات: MEDLINE
الوصف
تدمد:1582-4934
DOI:10.1111/jcmm.15682